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基于有害结局路径网络的有机磷酸酯毒性筛查及机制研究 学位论文
工学博士: 中国科学院烟台海岸带研究所, 2023
作者:  王晓晴
Adobe PDF(21053Kb)  |  收藏  |  浏览/下载：291/4  |  提交时间：2023/06/28
新污染物  有机磷酸酯  有害结局路径网络  计算毒理学  风险预测与评估  
Visualizing and evaluating mitochondrial cysteine via near-infrared fluorescence imaging in cells, tissues and in vivo under hypoxia/ reperfusion stress 期刊论文
JOURNAL OF HAZARDOUS MATERIALS, 2021, 卷号: 419, 页码: 10
作者:  Zhang, Xia;  Zhang, Liangwei;  Wang, Xiaoyan;  Han, Xiaoyue;  Huang, Yan;  Li, Bowei;  Chen, Lingxin
Adobe PDF(8055Kb)  |  收藏  |  浏览/下载：711/211  |  提交时间：2021/11/09
Fluorescent probe  Cysteine  Near-infrared imaging  Hypoxia  reperfusion  Environmental stress  
新型功能化荧光探针设计及在汞胁迫下生物活性物种的成像分析研究 学位论文
工学博士学位, 中国科学院烟台海岸带研究所: 中国科学院大学, 2021
作者:  王悦
Adobe PDF(12672Kb)  |  收藏  |  浏览/下载：331/2  |  提交时间：2021/06/24
荧光探针，汞胁迫，生物活性物种，荧光成像，环境分析  
Integration of Computational Toxicology, Toxicogenomics Data Mining, and Omics Techniques to Unveil Toxicity Pathways 期刊论文
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, 卷号: 9, 期号: 11, 页码: 4130-4138
作者:  Wang, Xiaoqing;  Li, Fei;  Chen, Jingwen;  Ji, Chenglong;  Wu, Huifeng
Adobe PDF(3938Kb)  |  收藏  |  浏览/下载：763/297  |  提交时间：2021/05/22
Adverse outcome pathway (AOP)  Comparative toxicogenomics database (CTD)  Triphenyl phosphate (TPP)  Molecular dynamics (MD)  Transcriptome analyses  
Glutathione Peroxidase-Activatable Two-Photon Ratiometric Fluorescent Probe for Redox Mechanism Research in Aging and Mercury Exposure Mice Models 期刊论文
ANALYTICAL CHEMISTRY, 2020, 卷号: 92, 期号: 2, 页码: 1997-2004
作者:  Wang, Y;  Zhang, LW;  Chen, LX
浏览  |  Adobe PDF(6352Kb)  |  收藏  |  浏览/下载：634/296  |  提交时间：2020/07/08
IN-VIVO  SELENOL  SELENOCYSTEINE  SELENOPROTEIN  NEUROTOXICITY  METABOLISM  SPECIATION  REDUCTASE  PROTEINS  STRESS  
A sulfydryl-based near-infrared ratiometic fluorescent probe for assessment of acute/chronic mercury exposure via associated determination of superoxide anion and mercury ion in cells and in vivo 期刊论文
SENSORS AND ACTUATORS B-CHEMICAL, 2019, 卷号: 301, 页码: 127038
作者:  Wang, Y;  Gao, M;  Liao, CY;  Yu, FB;  Chen, LX
浏览  |  Adobe PDF(4317Kb)  |  收藏  |  浏览/下载：545/278  |  提交时间：2020/07/08
Mercury poisoning  Near-infrared fluorescent probe  Ratiometric biomaging  Superoxide anion  Mercury ion  
A unique off-on near-infrared cyanine-based probe for imaging of endogenous alkaline phosphatase activity in cells and in vivo 期刊论文
SENSORS AND ACTUATORS B-CHEMICAL, 2018, 卷号: 265, 页码: 565-574
作者:  Gao, Zhiwei;  Sun, Jingya;  Gao, Min;  Yu, Fabiao;  Chen, Lingxin;  Chen, Qingguo
浏览  |  Adobe PDF(3223Kb)  |  收藏  |  浏览/下载：459/237  |  提交时间：2020/07/08
Alkaline phosphatase  Fluorescent probes  Near-infrared fluorescence  In vivo imaging  
Evaluation Selenocysteine Protective Effect in Carbon Disulfide Induced Hepatitis with a Mitochondrial Targeting Ratiometric Near-Infrared Fluorescent Probe 期刊论文
ANALYTICAL CHEMISTRY, 2018, 卷号: 90, 期号: 13, 页码: 8108-8115
作者:  Han, Xiaoyue;  Wang, Rui;  Song, Xinyu;  Yu, Fabiao;  Chen, Lingxin
Adobe PDF(6933Kb)  |  收藏  |  浏览/下载：464/275  |  提交时间：2020/07/08
PROTEIN-KINASE PATHWAYS  HUMAN HEALTH  SELENIUM  SELENOLS  CELLS  SELENOPROTEINS  SPECTROMETRY  DYSFUNCTION  TISSUES  PLASMA  
A Ratiometric Near-Infrared Fluorescent Probe for Quantification and Evaluation of Selenocysteine-Protective Effects in Acute Inflammation 期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2017, 卷号: 27, 期号: 28, 页码: 1700769
作者:  Han, Xiaoyue;  Song, Xinyu;  Yu, Fabiao;  Chen, Lingxin
收藏  |  浏览/下载：329/0  |  提交时间：2017/09/05
Inflammation  Near-infrared Fluorescent Probes  Protective Effects  Selenocysteine  
Quantification of cysteine hydropersulfide with a ratiometric near-infrared fluorescent probe based on selenium-sulfur exchange reaction 期刊论文
CHEMICAL SCIENCE, 2016, 卷号: 7, 期号: 8, 页码: 5098-5107
作者:  Han, XY;  Yu, FB;  Song, XY;  Chen, LX;  Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. Email:lxchen@yic.ac.cn
Adobe PDF(1026Kb)  |  收藏  |  浏览/下载：603/249  |  提交时间：2016/11/30