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合作作者[TOP 5]
吴惠丰
所在部门： 中国科学院海岸带环境过程与生态修复重点实验室
研究方向： 系统生物学和海洋生态毒理学
联系邮箱： hfwu@yic.ac.cn
备注： 招生方向：生态毒理学具有分子生物学，细胞生物学，生物化学，环境科学等专业背景的考生均可报考。
吴惠丰

研究内容

系统生物学和海洋生态毒理学

 

个人简介

      研究员，博士生导师。2005年毕业于中国科学院长春应用化学研究所，获理学博士学位。2005年至2009年先后在英国伯明翰大学生物系，香港科技大学生物系从事系统生物学和海洋生态毒理学博士后研究。2009年到中国科学院烟台海岸带研究所工作。主要研究领域为系统生物学和海洋生态毒理学。目前主持的主要项目有国家自然科学基金、国家重点基础研究发展计划（子课题）等。已发表SCI论文100余篇，他引3000余次，h指数为32。2017年，入选中科院“特聘”研究员，2018年入选享受国务院“政府特殊津贴”专家。

      目前共培养研究生22名。培养的研究生中，获得“中国科学院院长特别奖”1人次、“中国科学院院长优秀奖”１人次、“中国科学院大学-澳大利亚必和必拓”奖学金1人次、“刘瑞玉海洋科学奖”2人次、中科环保奖学金1人次、国家奖学金3人次、中国科学院百篇优秀博士论文1人次。吴惠丰研究员本人获2012年度“中国科学院大学-澳大利亚必和必拓”导师科研奖、2013年度“中国科学院优秀导师奖”、2014年度“中国科学院优秀指导教师奖”。

代表性论文：

  1. Xiangjing Meng, Fei Li*, Xiaoqing Wang, JialinLiu, Chenglong Ji, Huifeng Wu*. Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis. J. Hazard. Mater., 2019, 378, 120778.
  2. Chenglong Ji, Zhen Lu, Lanlan Xu, Fei Li, Ming Cong, Huifeng Wu*. Evaluation of mitochondrial toxicity of cadmium in clam Ruditapes philippinarum using iTRAQ-based proteomics. Environ. Pollut., 2019, 251, 802–810.
  3. Lizhu Chen, Huifeng Wu*, Jianmin Zhao, Wei Zhang, Li Zhang, Shan Sun, Dinglong Yang, Bo Cheng, Qing Wang*. The role of GST omega in metabolism and detoxification of arsenic in clam Ruditapes philippinarum. Aquat. Toxicol., 2018, 204, 9–18.
  4. Ming Cong, Huifeng Wu*, Tengfei Cao, Jiasen Lv, Qing Wang, Chenglong Ji, Chenghua Li, Jianmin Zhao. Digital gene expression analysis in the gills of Ruditapes philippinarum exposed to short- and long-term exposures of ammonia nitrogen. Aquat. Toxicol., 2018, 194, 121–131.
  5. 李斐，丁家旺，吴惠丰*，孟祥敬，赵建民. 电化学方法研究石墨烯和磷酸三苯酯(TPP)与模拟生物膜间的相互作用. 科学通报, 2017, 62 (36), 4285–4293.
  6. Fei Li, Li Wang, Chenglong Ji, Huifeng Wu*, Jianmin Zhao, Jianhui Tang. Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells. Chemosphere, 2017, 187, 88–96.
  7. Huifeng Wu*, Lanlan Xu, Deliang Yu, Chenglong Ji. Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium. Ecotoxicology, 2017, 26, 74–80.
  8. Lanlan Xu, Chenglong Ji, Jianmin Zhao, Huifeng Wu*. Metabolic responses to metal pollution in shrimp Crangon affinis from the sites along the Laizhou Bay in the Bohai Sea. Mar. Pollut. Bull., 2016, 113, 536–541.
  9. Lanlan Xu, Chenglong Ji, Huifeng Wu*, Qiaoguo Tan, Wen-Xiong Wang. A comparative proteomic study on the effects of metal pollution in oysters Crassostrea hongkongensis. Mar. Pollut. Bull., 2016, 112, 436–442.
  10. Chenglong Ji, Deliang Yu, Qing Wang, Fei Li, Jianmin Zhao, Huifeng Wu*. Impact of metal pollution on shrimp Crangon affinis by NMR-based metabolomics. Mar. Pollut. Bull., 2016, 106, 372–376.
  11. Chenglong Ji, Qing Wang, Huifeng Wu*, Qiaoguo Tan, Wen-Xiong Wang. A metabolomic study on the biological effects of metal pollutions in oysters Crassostrea sikamea. Mar. Pollut. Bull., 2016, 102, 216–222.
  12. Deliang Yu, Chenglong Ji, Jianmin Zhao, Huifeng Wu*. Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis. Chemosphere, 2016, 150, 194–201.
  13. Chenglong Ji, Fei Li, Qing Wang, Jianmin Zhao, Huifeng Wu*. An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA). Chemosphere, 2016, 144, 527–539.
  14. Lianzhen Li, Huifeng Wu*, Willie J. G. M. Peijnenburg, Cornelis A. M. van Gestel. M. Both released silver ions and particulate Ag contribute to the toxicity of AgNPs to earthworm Eisenia fetida. Nanotoxicology, 2015, 9, 792–801.
  15. 吴惠丰，曹璐璐，李斐*，李雪花，赵建民. 典型持久性有机污染物与抑癌基因相互作用的分子模拟与验证. 科学通报，2015, 60, 1804–1809.
  16. LianZhen Li, Huifeng Wu*, Chenglong Ji, Cornelis A.M. van Gestel, Herbert E. Allen, Willie J.G.M. Peijnenburg. A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles. Ecotoxicol. Environ. Saf., 2015, 119, 66–73.
  17. Huifeng Wu, Lulu Cao, Fei Li*, Peiwen Lian, Jianmin Zhao. Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells. Chemosphere, 2015, 126, 32–39.
  18. Lei Wei, Qing Wang, Xuanxuan Ning, Changkao Mu, Chunlin Wang, Ruiwen Cao, Huifeng Wu*, Ming Cong, Fei Li, Chenglong Ji, Jianmin Zhao. Combined metabolome and proteome analysis of the mantle tissue from Pacific oyster Crassostrea gigas exposed to elevated pCO2. Comp. Biochem. Physiol. Part D, 2015, 13, 16–23.
  19. Chenglong Ji, Qing Wang, Huifeng Wu*, Qiaoguo Tan, Wen-Xiong Wang. A metabolomic investigation of the effects of metal pollution in oysters Crassostrea hongkongensis. Mar. Pollut. Bull., 2015, 90, 317–322.
  20. Fei Li, Lulu Cao, Xuehua Li, Na Li, Zijian Wang, Huifeng Wu*. Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study. Toxicol. Lett., 2015, 232, 533–541.
  21. Lei Wei, Qing Wang, Huifeng Wu*, Chenglong Ji, Jianmin Zhao. Proteomic and metabolomic responses of Pacific oyster Crassostrea gigas to elevated pCO2 exposure. J. Proteomics, 2015, 112, 83–94.
  22. Fei Li, Xianhai Yang, Xuehua Li, Renmin Li, Jianmin Zhao, Huifeng Wu*. Determination and prediction of the binding interaction between organophosphate flame retardants and p53. Chem. Res. Toxicol., 2014, 27, 1918–1925.
  23. Chenglong Ji, Huifeng Wu*, Lei Wei, Jianmin Zhao. iTRAQ-based quantitative proteomic analyses on the gender-specific responses in mussel Mytilus galloprovincialis to tetrabromobisphenol A. Aquat. Toxicol., 2014, 157, 30–40.
  24. Fei Li, Renmin Li, Xianhai Yang, Liping You, Jianmin Zhao, Huifeng Wu*. The interaction between organic phosphate ester and p53: An integrated experimental and in silico approach. Mar. Pollut. Bull., 2014, 85, 516–521.
  25. Lianzhen Li, Huifeng Wu*, Cornelis A.M. van Gestel, Willie J.G.M. Peijnenburg, Herbert E. Allen. Soil acidification increases metal extractability and bioavailability in old orchard soils of Northeast Jiaodong Peninsula in China. Environ. Pollut., 2014, 188, 144–152.
  26. Huifeng Wu*, Chenglong Ji, Lei Wei, Jianmin Zhao. Evaluation of protein extraction protocols for 2DE in marine ecotoxicoproteomics. Proteomics, 2013, 13, 3205–3210.
  27. Huifeng Wu*, Chenglong Ji, Lei Wei, Jianmin Zhao, Hongjian Lu. Proteomic and metabolomic responses in hepatopancreas of Mytilus galloprovincialis challenged by Micrococcus luteus and Vibrio anguillarum. J. Proteomics, 2013, 94, 54–67.
  28. Chenglong Ji, Huifeng Wu*, Lei Wei, Jianmin Zhao, Hongjian Lu, Junbao Yu. Proteomic and metabolomic analysis of earthworm Eisenia fetida exposed to different concentrations of 2,2’,4,4’-tetrabromodiphenyl ether. J. Proteomics, 2013, 91, 405–416.
  29. Chenglong Ji, Huifeng Wu*, Lei Wei, Jianmin Zhao, Junbao Yu. Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2’,4,4’-tetrabromodiphenyl ether (BDE 47). Aquat. Toxicol., 2013, 140–141, 449–457.
  30. Huifeng Wu*, Xiaoli Liu, Xingyan Zhang, Chenglong Ji, Jianmin Zhao, Junbao Yu. Proteomic and metabolomic responses of clam Ruditapes philippinarum to arsenic exposure under different salinities. Aquat. Toxicol., 2013, 136–137, 91–100.
  31. Linbao Zhang, Xiaoli Liu, Liping You, Di Zhou, Huifeng Wu*, Lianzhen Li, Jianmin Zhao, Jianghua Feng, Junbao Yu. Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics. Mar. Environ. Res., 2011, 72, 33–39.
  32. Huifeng Wu, Wen-Xiong Wang*. Tissue-specific toxicological effects of cadmium in green mussel (Perna viridis): Nuclear magnetic resonance-based metabolomics study. Environ. Toxicol. Chem., 2011, 30, 806–812.
  33. Huifeng Wu, Wen-Xiong Wang*. NMR-based metabolomic studies on the toxicological effects of cadmium and copper on green mussels Perna viridis. Aquat. Toxicol., 2010, 100, 339–345.
  34. Huifeng Wu, Andrew D. Southam, Adam Hines, Mark R. Viant*. High throughput tissue extraction protocol for NMR and Mass spectrometry based metabolomics. Anal. Biochem., 2008, 372, 204–212.

主要科研成果

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