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Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP) 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 卷号: 205, 页码: 9
作者:  Wang, Xiaoqing;  Li, Fei;  Liu, Jialin;  Ji, Chenglong;  Wu, Huifeng
Adobe PDF(6774Kb)  |  收藏  |  浏览/下载：416/53  |  提交时间：2021/06/21
Triphenyl phosphate (TPP)  Multi-omit approach  Hepatotoxicity  
Global responses to tris(1-chloro-2-propyl)phosphate (TCPP) in rockfish Sebastes schlegeli using integrated proteomic and metabolomic approach 期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 卷号: 724, 页码: 9
作者:  Ji, Chenglong;  Lu, Zhen;  Xu, Lanlan;  Li, Fei;  Cong, Ming;  Shan, Xiujuan;  Wu, Huifeng
Adobe PDF(1872Kb)  |  收藏  |  浏览/下载：818/367  |  提交时间：2020/07/08
ORGANOPHOSPHATE FLAME RETARDANTS  MESSENGER-RNA EXPRESSION  CELL-ADHESION MOLECULE  EARLY-LIFE STAGES  DEVELOPMENTAL NEUROTOXICITY  SPATIAL-DISTRIBUTION  SYNAPSIN I  PLASTICIZERS  TARGET  PHOSPHATE  
iTRAQ-based proteomic analysis on the mitochondrial responses in gill tissues of juvenile olive flounder Paralichthys olivaceus exposed to cadmium 期刊论文
ENVIRONMENTAL POLLUTION, 2020, 卷号: 257, 页码: 113591
作者:  Lu, Z;  Wang, S;  Ji, CL;  Li, F;  Cong, M;  Shan, XJ;  Wu, HF
浏览  |  Adobe PDF(2097Kb)  |  收藏  |  浏览/下载：733/382  |  提交时间：2020/07/08
Cadmium  Paralichthys olivaceus  iTRAQ  Proteomics  Mitochondrial toxicity  
Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach 期刊论文
ENVIRONMENTAL POLLUTION, 2019, 卷号: 255, 期号: 2, 页码: 113333
作者:  Xu, LL;  Lu, Z;  Ji, CL;  Cong, M;  Li, F;  Shan, XJ;  Wu, HF
浏览  |  Adobe PDF(1885Kb)  |  收藏  |  浏览/下载：572/295  |  提交时间：2020/07/08
Arsenic  Toxicological effect  Juvenile rockfish  Proteomics  Metabolomics  
Evaluation of mitochondrial toxicity of cadmium in clam Ruditapes philippinarum using iTRAQ-based proteomics 期刊论文
ENVIRONMENTAL POLLUTION, 2019, 卷号: 251, 页码: 802-810
作者:  Ji, CL;  Lu, Z;  Xu, LL;  Li, F;  Cong, M;  Shan, XJ;  Wu, HF
浏览  |  Adobe PDF(1493Kb)  |  收藏  |  浏览/下载：532/294  |  提交时间：2020/07/08
Cadmium  iTRAQ  Proteomics  Mitochondrial toxicity  Ruditapes philippinarum  
Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells 期刊论文
CHEMOSPHERE, 2015, 卷号: 126, 页码: 32-39
作者:  Wu, Huifeng;  Cao, Lulu;  Li, Fei;  Lian, Peiwen;  Zhao, Jianmin;  Li, F (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Shandong, Peoples R China. fli@yic.ac.cn
浏览  |  Adobe PDF(765Kb)  |  收藏  |  浏览/下载：901/381  |  提交时间：2015/07/31
Bde-47  Hek293 Cells  Cytotoxicity  Cell Apoptosis  Ros  Metabolomics  
Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study 期刊论文
TOXICOLOGY LETTERS, 2015, 卷号: 232, 期号: 2, 页码: 533-541
作者:  Li, Fei;  Cao, Lulu;  Li, Xuehua;  Li, Na;  Wang, Zijian;  Wu, Huifeng;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(2093Kb)  |  收藏  |  浏览/下载：827/293  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs)  P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Partial Least Squares (Pls)  
Two Goose-Type Lysozymes in Mytilus galloprovincialis: Possible Function Diversification and Adaptive Evolution 期刊论文
PLOS ONE, 2012, 卷号: 7, 期号: 9, 页码: e45148
作者:  Wang, Qing;  Zhang, Linbao;  Zhao, Jianmin;  You, Liping;  Wu, Huifeng
浏览  |  Adobe PDF(569Kb)  |  收藏  |  浏览/下载：894/223  |  提交时间：2013/03/08
Oyster Crassostrea-virginica  I-type Lysozymes  Lytic Activity  Molecular Adaptation  Recombinant Protein  Positive Selection  Stomach Lysozymes  Eastern Oyster  Egg-white  Phylogenetic Analysis  
Noncovalent interactions between hydroxylated polycyclic aromatic hydrocarbon and DNA: Molecular docking and QSAR study 期刊论文
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2011, 卷号: 32, 期号: 3, 页码: 373-381
作者:  Li, Fei;  Li, Xuehua;  Liu, Xiaoli;  Zhang, Linbao;  You, Liping;  Zhao, Jianmin;  Wu, Huifeng
浏览  |  Adobe PDF(501Kb)  |  收藏  |  浏览/下载：1540/487  |  提交时间：2012/03/06
Hydroxylated Polycyclic Aromatic Hydrocarbon (Ho-pah)  Dna  Quantitative Structure-activity Relationship (Qsar)  Binding Interaction  Docking  
Allelochemical ethyl 2-methyl acetoacetate (EMA) induces oxidative damage and antioxidant responses in Phaeodactylum tricornutum 期刊论文
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2011, 卷号: 100, 期号: 1, 页码: 93-103
作者:  Yang, Cui-Yun;  Liu, Su-Jing;  Zhou, Shi-Wei;  Wu, Hui-Feng;  Yu, Jun-Bao;  Xia, Chuan-Hai
Adobe PDF(354Kb)  |  收藏  |  浏览/下载：1468/485  |  提交时间：2011/07/22
Phaeodactylum Tricornutum  Ethyl 2-mEthyl Acetoacetate  Reactive Oxygen Species  Malondialdehyde  Antioxidant Enzyme