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| Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP) | |
Wang, Xiaoqing1,3 ; Li, Fei1,4; Liu, Jialin1; Ji, Chenglong1,2,4; Wu, Huifeng1,2,4
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| 发表期刊 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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| ISSN | 0147-6513 |
| 2020-12-01 | |
| 卷号 | 205页码:9 |
| 关键词 | Triphenyl phosphate (TPP) Multi-omit approach Hepatotoxicity |
| DOI | 10.1016/j.ecoenv.2020.111126 |
| 通讯作者 | Li, Fei(fli@yic.ac.cn) ; Wu, Huifeng(hfwu@yic.ac.cn) |
| 英文摘要 | Triphenyl phosphate (TPP) has been found in various environmental media and in biota suggesting widespread human exposure. However, there is still insufficient information on the hepatotoxicity mechanisms of health risk exposed to TPP. In this study, TPP could induce human normal liver cell (L02) apoptosis, injury cell ultrastructure and elevate the levels of reactive oxygen species (ROS). The integrated multi-omit (transcriptomic, proteomic, and metabolomic) analysis was used to further investigate the mechanisms. Transcriptomic analysis revealed that TPP exposure markedly affected cell apoptosis, oncogene activation, REDOX homeostasis, DNA damage and repair. Additionally, proteomic analysis found that the related proteins associated with apoptosis, oxidative stress, metabolism and membrane structure were affected. And metabolomic analysis verified that the related metabolic pathways, such as glycolysis, citrate cycle, oxidative phosphorylation, lipid and protein metabolism, were also significantly disrupted. Based on the multi-omic results, a hypothesized network was constructed to discover the key molecular events in response to TPP and illustrate the mechanism of TPP-induced hepatotoxicity in L02 cells. Therefore, molecular responses could be elucidated at multiple biological levels, and multi-omic analysis could provide scientific tools for exploring potential mechanisms of toxicity and chemical risk assessment. |
| 资助机构 | National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ORGANOPHOSPHORUS FLAME RETARDANTS ; IN-VITRO ; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE ; ANTIANDROGENIC ACTIVITY ; DNA-REPAIR ; CELLS ; P53 ; PLASTICIZERS ; NMR ; MITOCHONDRIA |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Toxicology |
| WOS记录号 | WOS:000582219300017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/28420 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 支撑部门 |
| 通讯作者 | Li, Fei; Wu, Huifeng |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaoqing,Li, Fei,Liu, Jialin,et al. Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP)[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2020,205:9. |
| APA | Wang, Xiaoqing,Li, Fei,Liu, Jialin,Ji, Chenglong,&Wu, Huifeng.(2020).Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP).ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,205,9. |
| MLA | Wang, Xiaoqing,et al."Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP)".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 205(2020):9. |
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