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| Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach | |
Xu, LL; Lu, Z; Ji, CL ; Cong, M; Li, F; Shan, XJ; Wu, HF
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| 发表期刊 | ENVIRONMENTAL POLLUTION
 |
| ISSN | 0269-7491 |
| 2019-12 | |
| 卷号 | 255期号:2页码:113333 |
| 关键词 | Arsenic Toxicological effect Juvenile rockfish Proteomics Metabolomics |
| 研究领域 | Environmental Sciences |
| DOI | 10.1016/j.envpol.2019.113333 |
| 产权排序 | [Xu, Lanlan; Lu, Zhen; Ji, Chenglong; Cong, Ming; Li, Fei; Wu, Huifeng] Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China; [Ji, Chenglong; Shan, Xiujuan; Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China; [Xu, Lanlan; Lu, Zhen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Wu, Huifeng(hfwu@yic.ac.cn) |
| 作者部门 | 海岸带环境过程实验室 |
| 英文摘要 | Arsenic (As) is a metalloid element that is ubiquitous in the marine environment and its contamination has received worldwide attention due to its potential toxicity. Arsenic can induce multiple adverse effects, such as lipid metabolism disorder, immune system dysfunction, oxidative stress and carcinogenesis, in animals. Inorganic arsenic includes two chemical forms, arsenite (As (III)) and arsenate (As (V)), in natural environment. As (V) is the dominant form in natural waters. In the present study, metabolomic and proteomic alterations were investigated in juvenile rockfish Sebastes schlegelii exposed to environmentally relevant concentrations of As (V) for 14 d. The analysis of iTRAQ-based proteomics combined with untargeted NMR-based metabolomics indicated apparent toxicological effects induced by As (V) in juvenile rockfish. In details, the metabolites, including lactate, alanine, ATP, inosine and phosphocholine were significantly altered in As-treated groups. Proteomic responses suggested that As (V) could not only affected energy and primary metabolisms and signal transduction, but also influenced cytoskeleton structure in juvenile rockfish. This work suggested that the combined proteomic and metabolomic approach could shed light on the toxicological effects of pollutants in rockfish S. schlegelii. (C) 2019 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | NSFCNational Natural Science Foundation of China [41676114] ; Young Taishan Scholars Program of Shandong Province [tsqn201812115] ; Qingdao National Laboratory for Marine Science and Technology [QNLM201701] ; Youth Innovation Promotion Association CAS [2015169] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | CLAM RUDITAPES-PHILIPPINARUM ; FISH LIZA-AURATA ; CASEIN KINASE-I ; OXIDATIVE STRESS ; MYTILUS-GALLOPROVINCIALIS ; ARSENIC EXPOSURE ; HEAVY-METALS ; RESPONSES ; MECHANISMS ; MERCURY |
| 研究领域[WOS] | Environmental Sciences |
| WOS记录号 | WOS:000498340400088 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24807 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 |
| 作者单位 | 1.Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China; 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, LL,Lu, Z,Ji, CL,et al. Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach[J]. ENVIRONMENTAL POLLUTION,2019,255(2):113333. |
| APA | Xu, LL.,Lu, Z.,Ji, CL.,Cong, M.,Li, F.,...&Wu, HF.(2019).Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach.ENVIRONMENTAL POLLUTION,255(2),113333. |
| MLA | Xu, LL,et al."Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach".ENVIRONMENTAL POLLUTION 255.2(2019):113333. |
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