Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach
Xu, LL; Lu, Z; Ji, CL; Cong, M; Li, F; Shan, XJ; Wu, HF
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
2019-12
Volume255Issue:2Pages:113333
KeywordArsenic Toxicological effect Juvenile rockfish Proteomics Metabolomics
MOST Discipline CatalogueEnvironmental Sciences
DOI10.1016/j.envpol.2019.113333
Contribution Rank[Xu, Lanlan; Lu, Zhen; Ji, Chenglong; Cong, Ming; Li, Fei; Wu, Huifeng] Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China; [Ji, Chenglong; Shan, Xiujuan; Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China; [Xu, Lanlan; Lu, Zhen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Department海岸带环境过程实验室
AbstractArsenic (As) is a metalloid element that is ubiquitous in the marine environment and its contamination has received worldwide attention due to its potential toxicity. Arsenic can induce multiple adverse effects, such as lipid metabolism disorder, immune system dysfunction, oxidative stress and carcinogenesis, in animals. Inorganic arsenic includes two chemical forms, arsenite (As (III)) and arsenate (As (V)), in natural environment. As (V) is the dominant form in natural waters. In the present study, metabolomic and proteomic alterations were investigated in juvenile rockfish Sebastes schlegelii exposed to environmentally relevant concentrations of As (V) for 14 d. The analysis of iTRAQ-based proteomics combined with untargeted NMR-based metabolomics indicated apparent toxicological effects induced by As (V) in juvenile rockfish. In details, the metabolites, including lactate, alanine, ATP, inosine and phosphocholine were significantly altered in As-treated groups. Proteomic responses suggested that As (V) could not only affected energy and primary metabolisms and signal transduction, but also influenced cytoskeleton structure in juvenile rockfish. This work suggested that the combined proteomic and metabolomic approach could shed light on the toxicological effects of pollutants in rockfish S. schlegelii. (C) 2019 Elsevier Ltd. All rights reserved.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordCLAM RUDITAPES-PHILIPPINARUM ; FISH LIZA-AURATA ; CASEIN KINASE-I ; OXIDATIVE STRESS ; MYTILUS-GALLOPROVINCIALIS ; ARSENIC EXPOSURE ; HEAVY-METALS ; RESPONSES ; MECHANISMS ; MERCURY
WOS Research AreaEnvironmental Sciences
WOS IDWOS:000498340400088
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24807
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
Affiliation1.Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China;
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Xu, LL,Lu, Z,Ji, CL,et al. Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach[J]. ENVIRONMENTAL POLLUTION,2019,255(2):113333.
APA Xu, LL.,Lu, Z.,Ji, CL.,Cong, M.,Li, F.,...&Wu, HF.(2019).Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach.ENVIRONMENTAL POLLUTION,255(2),113333.
MLA Xu, LL,et al."Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach".ENVIRONMENTAL POLLUTION 255.2(2019):113333.
Files in This Item: Download All
File Name/Size DocType Version Access License
Toxicological effect(1885KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xu, LL]'s Articles
[Lu, Z]'s Articles
[Ji, CL]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xu, LL]'s Articles
[Lu, Z]'s Articles
[Ji, CL]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, LL]'s Articles
[Lu, Z]'s Articles
[Ji, CL]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.