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Integration of Computational Toxicology, Toxicogenomics Data Mining, and Omics Techniques to Unveil Toxicity Pathways 期刊论文
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, 卷号: 9, 期号: 11, 页码: 4130-4138
作者:  Wang, Xiaoqing;  Li, Fei;  Chen, Jingwen;  Ji, Chenglong;  Wu, Huifeng
浏览  |  Adobe PDF(3938Kb)  |  收藏  |  浏览/下载：808/310  |  提交时间：2021/05/22
Adverse outcome pathway (AOP)  Comparative toxicogenomics database (CTD)  Triphenyl phosphate (TPP)  Molecular dynamics (MD)  Transcriptome analyses  
Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP) 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 卷号: 205, 页码: 9
作者:  Wang, Xiaoqing;  Li, Fei;  Liu, Jialin;  Ji, Chenglong;  Wu, Huifeng
浏览  |  Adobe PDF(6774Kb)  |  收藏  |  浏览/下载：450/54  |  提交时间：2021/06/21
Triphenyl phosphate (TPP)  Multi-omit approach  Hepatotoxicity  
Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum 期刊论文
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2019, 卷号: 65, 页码: 46-52
作者:  Cong, Ming;  Wu, Huifeng;  Cao, Tengfei;  Ji, Chenglong;  Lv, Jiasen
浏览  |  Adobe PDF(2069Kb)  |  收藏  |  浏览/下载：563/295  |  提交时间：2020/07/08
Ruditapes philippinarum  Ammonia nitrogen  Mitochondrial transmembrane potential  ATPase  Gill function  Histological observation  
Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells 期刊论文
CHEMOSPHERE, 2015, 卷号: 126, 页码: 32-39
作者:  Wu, Huifeng;  Cao, Lulu;  Li, Fei;  Lian, Peiwen;  Zhao, Jianmin;  Li, F (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Shandong, Peoples R China. fli@yic.ac.cn
浏览  |  Adobe PDF(765Kb)  |  收藏  |  浏览/下载：941/393  |  提交时间：2015/07/31
Bde-47  Hek293 Cells  Cytotoxicity  Cell Apoptosis  Ros  Metabolomics  
Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study 期刊论文
TOXICOLOGY LETTERS, 2015, 卷号: 232, 期号: 2, 页码: 533-541
作者:  Li, Fei;  Cao, Lulu;  Li, Xuehua;  Li, Na;  Wang, Zijian;  Wu, Huifeng;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(2093Kb)  |  收藏  |  浏览/下载：862/302  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs)  P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Partial Least Squares (Pls)  
Determination and Prediction of the Binding Interaction between Organophosphate Flame Retardants and p53 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2014, 卷号: 27, 期号: 11, 页码: 1918-1925
作者:  Li, Fei;  Yang, Xianhai;  Li, Xuehua;  Li, Renmin;  Zhao, Jianmin;  Wu, Huifeng;  Li, F (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. fli@yic.ac.cn;  hfwu@yic.ac.cn
浏览  |  Adobe PDF(1104Kb)  |  收藏  |  浏览/下载：906/405  |  提交时间：2015/07/31
Polybrominated Diphenyl Ethers  Thyroid-hormone Receptors  Structural Requirements  Surface Waters  In-silico  Plasticizers  Complex  Air  Regression  Zebrafish  
Metabolic responses of HeLa cells to silica nanoparticles by NMR-based metabolomic analyses 期刊论文
METABOLOMICS, 2013, 卷号: 9, 期号: 4, 页码: 874-886
作者:  Feng, Jianghua;  Li, Jinquan;  Wu, Huifeng;  Chen, Zhong
浏览  |  Adobe PDF(794Kb)  |  收藏  |  浏览/下载：1157/407  |  提交时间：2014/07/08
Silica Nanoparticles  Metabolomic Analysis  Nmr Spectroscopy  Nanomedicine  Hela Cell  
Two Goose-Type Lysozymes in Mytilus galloprovincialis: Possible Function Diversification and Adaptive Evolution 期刊论文
PLOS ONE, 2012, 卷号: 7, 期号: 9, 页码: e45148
作者:  Wang, Qing;  Zhang, Linbao;  Zhao, Jianmin;  You, Liping;  Wu, Huifeng
浏览  |  Adobe PDF(569Kb)  |  收藏  |  浏览/下载：933/234  |  提交时间：2013/03/08
Oyster Crassostrea-virginica  I-type Lysozymes  Lytic Activity  Molecular Adaptation  Recombinant Protein  Positive Selection  Stomach Lysozymes  Eastern Oyster  Egg-white  Phylogenetic Analysis