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Critical target identification and human health risk ranking of metal ions based on mechanism-driven modeling 期刊论文
CHEMOSPHERE, 2022, 卷号: 301, 页码: 9
作者:  Wang, Xiaoqing;  Teng, Yuefa;  Ji, Chenglong;  Wu, Huifeng;  Li, Fei
收藏  |  浏览/下载：278/0  |  提交时间：2022/07/26
Metal ions  p53  QSAR  Genetic toxicity  Human health risk  
Integration of Computational Toxicology, Toxicogenomics Data Mining, and Omics Techniques to Unveil Toxicity Pathways 期刊论文
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, 卷号: 9, 期号: 11, 页码: 4130-4138
作者:  Wang, Xiaoqing;  Li, Fei;  Chen, Jingwen;  Ji, Chenglong;  Wu, Huifeng
浏览  |  Adobe PDF(3938Kb)  |  收藏  |  浏览/下载：756/296  |  提交时间：2021/05/22
Adverse outcome pathway (AOP)  Comparative toxicogenomics database (CTD)  Triphenyl phosphate (TPP)  Molecular dynamics (MD)  Transcriptome analyses  
典型溴系阻燃剂四溴双酚A和十溴二苯乙烷的污染现状及毒理学研究进展 期刊论文
生态毒理学报, 2020, 卷号: 15, 期号: 6, 页码: 24-42
作者:  王爽;  路珍;  李斐;  丛明;  吉成龙;  吴惠丰
浏览  |  Adobe PDF(646Kb)  |  收藏  |  浏览/下载：699/268  |  提交时间：2021/12/01
四溴双酚A  十溴二苯乙烷  毒性效应  污染现状  
Digital gene expression analysis in the gills of Ruditapes philippinarum after nitrite exposure 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 184, 页码: 7
作者:  Lv, Jiasen;  Cao, Tengfei;  Ji, Chenglong;  Cong, Ming;  Zhao, Jianmin;  Wu, Huifeng
浏览  |  Adobe PDF(594Kb)  |  收藏  |  浏览/下载：468/190  |  提交时间：2021/06/22
Digital gene expression  Gills  Ruditapes philippinarum  Nitrite  
The critical factors affecting typical organophosphate flame retardants to mimetic biomembrane: An integrated in vitro and in silico study 期刊论文
CHEMOSPHERE, 2019, 卷号: 226, 页码: 159-165
作者:  Wang, XQ;  Meng, XJ;  Li, F;  Ding, JW;  Ji, CL;  Wu, HF
浏览  |  Adobe PDF(969Kb)  |  收藏  |  浏览/下载：524/212  |  提交时间：2020/07/08
Organophosphate flame retardants (OPFRs)  Quantitative structure-activity relationship (QSAR)  Mimetic biomembrane  Electrochemical impedance spectroscopy (EIS)  Partial least squares (PLS)  
一种预测生物标志物p53与有机磷酸酯阻燃剂相互作用亲和力的方法 专利
专利号: 2014101576210, 申请日期: 2017-01-11,
发明人:  李斐;  曹璐璐;  吴惠丰;  赵建民
收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26
Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study 期刊论文
TOXICOLOGY LETTERS, 2015, 卷号: 232, 期号: 2, 页码: 533-541
作者:  Li, Fei;  Cao, Lulu;  Li, Xuehua;  Li, Na;  Wang, Zijian;  Wu, Huifeng;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(2093Kb)  |  收藏  |  浏览/下载：827/293  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs)  P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Partial Least Squares (Pls)  
Determination and Prediction of the Binding Interaction between Organophosphate Flame Retardants and p53 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2014, 卷号: 27, 期号: 11, 页码: 1918-1925
作者:  Li, Fei;  Yang, Xianhai;  Li, Xuehua;  Li, Renmin;  Zhao, Jianmin;  Wu, Huifeng;  Li, F (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. fli@yic.ac.cn;  hfwu@yic.ac.cn
浏览  |  Adobe PDF(1104Kb)  |  收藏  |  浏览/下载：863/387  |  提交时间：2015/07/31
Polybrominated Diphenyl Ethers  Thyroid-hormone Receptors  Structural Requirements  Surface Waters  In-silico  Plasticizers  Complex  Air  Regression  Zebrafish  
The interaction between organic phosphate ester and p53: An integrated experimental and in silico approach 期刊论文
MARINE POLLUTION BULLETIN, 2014, 卷号: 85, 期号: 2, 页码: 516-521
作者:  Li, Fei;  Li, Renmin;  Yang, Xianhai;  You, Liping;  Zhao, Jianmin;  Wu, Huifeng;  Li, F (reprint author), Chinese Acad Sci, YICCAS, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China. fli@yic.ac.cn;  hfwu@yic.ac.cn
浏览  |  Adobe PDF(915Kb)  |  收藏  |  浏览/下载：632/234  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs) P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Multiple Linear Regression (Mlr)  
Two Goose-Type Lysozymes in Mytilus galloprovincialis: Possible Function Diversification and Adaptive Evolution 期刊论文
PLOS ONE, 2012, 卷号: 7, 期号: 9, 页码: e45148
作者:  Wang, Qing;  Zhang, Linbao;  Zhao, Jianmin;  You, Liping;  Wu, Huifeng
浏览  |  Adobe PDF(569Kb)  |  收藏  |  浏览/下载：894/223  |  提交时间：2013/03/08
Oyster Crassostrea-virginica  I-type Lysozymes  Lytic Activity  Molecular Adaptation  Recombinant Protein  Positive Selection  Stomach Lysozymes  Eastern Oyster  Egg-white  Phylogenetic Analysis