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Ammonia nitrogen exposure caused structural damages to gill mitochondria of clam Ruditapes philippinarum 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 卷号: 222, 页码: 7
作者:  Cong, Ming;  Li, Yuanmei;  Xu, Hongchao;  Lv, Jiasen;  Wu, Huifeng;  Zhao, Ye
Adobe PDF(3140Kb)  |  收藏  |  浏览/下载：527/184  |  提交时间：2021/11/08
Ammonia nitrogen  Gill mitochondria  Swelling  MtDNA copy  Succinic dehydrogenase  Mitochondrial ultrastructure  
Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP) 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 卷号: 205, 页码: 9
作者:  Wang, Xiaoqing;  Li, Fei;  Liu, Jialin;  Ji, Chenglong;  Wu, Huifeng
浏览  |  Adobe PDF(6774Kb)  |  收藏  |  浏览/下载：424/54  |  提交时间：2021/06/21
Triphenyl phosphate (TPP)  Multi-omit approach  Hepatotoxicity  
Proteomic responses induced by metal pollutions in oysters Crassostrea sikamea 期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2019, 卷号: 37, 期号: 2, 页码: 685-693
作者:  Lu, Z;  Shan, XJ;  Ji, CL;  Zhao, JM;  Wu, HF
浏览  |  Adobe PDF(508Kb)  |  收藏  |  浏览/下载：479/229  |  提交时间：2020/07/08
metal pollution  Crassostrea sikamea  biological effect  proteomics  
Individual and Combined Toxicities of Benzo[a]pyrene and 2,2',4,4'-Tetrabromodiphenyl Ether on Early Life Stages of the Pacific Oyster, Crassostrea gigas 期刊论文
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2017, 卷号: 99, 期号: 5, 页码: 582-588
作者:  Xie, J;  Yang, DL;  Sun, XY;  Cao, RW;  Chen, LZ;  Wang, Q;  Li, F;  Wu, HF;  Ji, CL;  Cong, M;  Zhao, JM
Adobe PDF(1526Kb)  |  收藏  |  浏览/下载：374/23  |  提交时间：2020/07/08
Embryotoxicity  Larval mortality  Genotoxicity  BaP  BDE-47  Combined toxicity  
Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2016, 卷号: 58, 页码: 514-520
作者:  Wu, Huifeng;  Xu, Lanlan;  Ji, Chenglong;  Yu, Deliang;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Key Lab Coastal Zone Environm Proc,Yantai Inst Co, Yantai 264003, Peoples R China. Email:hfwu@yic.ac.cn
浏览  |  Adobe PDF(921Kb)  |  收藏  |  浏览/下载：699/309  |  提交时间：2016/12/19
Mytilus Galloprovincialis  Cadmium  Arsenic  Biological Effects  Proteomics  Metabolomics  
Homologous cloning, characterization and expression of a new halophyte phytochelatin synthase gene in Suaeda salsa 期刊论文
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2016, 卷号: 34, 期号: 5, 页码: 1034-1043
作者:  Cong, M;  Zhao, JM;  Lu, JS;  Ren, ZM;  Wu, HF;  Wu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(435Kb)  |  收藏  |  浏览/下载：708/318  |  提交时间：2016/10/08
Suaeda Salsa  Halophyte  Phytochelatin Synthase (Pcs)  Homologous Cloning  Heavy Metal  Tissue Distribution  
Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study 期刊论文
TOXICOLOGY LETTERS, 2015, 卷号: 232, 期号: 2, 页码: 533-541
作者:  Li, Fei;  Cao, Lulu;  Li, Xuehua;  Li, Na;  Wang, Zijian;  Wu, Huifeng;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(2093Kb)  |  收藏  |  浏览/下载：838/297  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs)  P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Partial Least Squares (Pls)  
BDE-47对人胚肾细胞HEK293的毒理效应及作用机制 期刊论文
生态毒理学报, 2015, 卷号: ., 期号: 2, 页码: 236-242
作者:  曹璐璐;  李斐;  吴惠丰;  赵建民
浏览  |  Adobe PDF(304Kb)  |  收藏  |  浏览/下载：430/173  |  提交时间：2021/06/16
2,2’,4,4’-四溴联苯醚（BDE-47）  人胚肾细胞  细胞凋亡  氧化损伤  p53  Bax  
The interaction between organic phosphate ester and p53: An integrated experimental and in silico approach 期刊论文
MARINE POLLUTION BULLETIN, 2014, 卷号: 85, 期号: 2, 页码: 516-521
作者:  Li, Fei;  Li, Renmin;  Yang, Xianhai;  You, Liping;  Zhao, Jianmin;  Wu, Huifeng;  Li, F (reprint author), Chinese Acad Sci, YICCAS, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China. fli@yic.ac.cn;  hfwu@yic.ac.cn
浏览  |  Adobe PDF(915Kb)  |  收藏  |  浏览/下载：642/239  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs) P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Multiple Linear Regression (Mlr)  
Metabolomic analysis revealed the differential responses in two pedigrees of clam Ruditapes philippinarum towards Vibrio harveyi challenge 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2013, 卷号: 35, 期号: 6, 页码: 1969-1975
作者:  Liu, Xiaoli;  Zhao, Jianmin;  Wu, Huifeng;  Wang, Qing
Adobe PDF(807Kb)  |  收藏  |  浏览/下载：900/207  |  提交时间：2014/07/08
Metabolomics  Ruditapes Philippinarum  Pedigree  Vibrio Harveyi  Hepatopancreas