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Integration of Computational Toxicology, Toxicogenomics Data Mining, and Omics Techniques to Unveil Toxicity Pathways 期刊论文
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, 卷号: 9, 期号: 11, 页码: 4130-4138
作者:  Wang, Xiaoqing;  Li, Fei;  Chen, Jingwen;  Ji, Chenglong;  Wu, Huifeng
浏览  |  Adobe PDF(3938Kb)  |  收藏  |  浏览/下载：809/311  |  提交时间：2021/05/22
Adverse outcome pathway (AOP)  Comparative toxicogenomics database (CTD)  Triphenyl phosphate (TPP)  Molecular dynamics (MD)  Transcriptome analyses  
Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach 期刊论文
ENVIRONMENTAL POLLUTION, 2019, 卷号: 255, 期号: 2, 页码: 113333
作者:  Xu, LL;  Lu, Z;  Ji, CL;  Cong, M;  Li, F;  Shan, XJ;  Wu, HF
浏览  |  Adobe PDF(1885Kb)  |  收藏  |  浏览/下载：616/312  |  提交时间：2020/07/08
Arsenic  Toxicological effect  Juvenile rockfish  Proteomics  Metabolomics  
石墨烯与抑癌基因p53 DNA片段相互作用的分子模拟与光谱学验证 期刊论文
生态毒理学报, 2017, 卷号: 12, 期号: 3, 页码: 243-250
作者:  吴惠丰;  张明兴;  李斐;  曹天贵;  李雪花;  赵建民
收藏  |  浏览/下载：181/0  |  提交时间：2020/07/07
p53-DNA  graphene(G)  p53-DNA  binding interaction  molecular dynamics simulations  spectroscopic methods  石墨烯  相互作用  分子动力学模拟  光谱法  
典型持久性有机污染物与抑癌基因相互作用的分子模拟与验证 期刊论文
科学通报, 2015, 卷号: 60, 期号: 19, 页码: 1804-1809
作者:  吴惠丰;  曹璐璐;  李斐;  李雪花;  赵建民
浏览  |  Adobe PDF(1577Kb)  |  收藏  |  浏览/下载：739/322  |  提交时间：2016/12/15
持久性有机污染物  P53  2  分子模拟  2'  光谱法  4  4'-四溴联苯醚(Bde-47)  
Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms 期刊论文
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2015, 卷号: 33, 期号: 3, 页码: 705-713
作者:  Li Fei;  Wu Huifeng;  Wang Qing;  Li Xuehua;  Zhao Jianmin;  Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(580Kb)  |  收藏  |  浏览/下载：921/311  |  提交时间：2015/07/31
Glutathione S-transferase (Gst)  Venerupis Philippinarum  Mytilus Galloprovincialis  Molecular Docking  2  Biomarker  2 '  4  4 '-tetrabromodiphenyl Ether (Bde-47)  
Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study 期刊论文
TOXICOLOGY LETTERS, 2015, 卷号: 232, 期号: 2, 页码: 533-541
作者:  Li, Fei;  Cao, Lulu;  Li, Xuehua;  Li, Na;  Wang, Zijian;  Wu, Huifeng;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(2093Kb)  |  收藏  |  浏览/下载：863/303  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs)  P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Partial Least Squares (Pls)