Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms | |
Li Fei; Wu Huifeng; Wang Qing; Li Xuehua; Zhao Jianmin; Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn | |
发表期刊 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY |
ISSN | 0254-4059 |
2015-05 | |
卷号 | 33期号:3页码:705-713 |
关键词 | Glutathione S-transferase (Gst) Venerupis Philippinarum Mytilus Galloprovincialis Molecular Docking 2 Biomarker 2 ' 4 4 '-tetrabromodiphenyl Ether (Bde-47) |
DOI | 10.1007/s00343-015-4127-5 |
产权排序 | [Li Fei; Wu Huifeng; Wang Qing; Zhao Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Li Xuehua] Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn MOE, Dalian 116024, Peoples R China |
作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
英文摘要 | Glutathione S-transferases (GSTs) are phase II enzymes that facilitate the detoxification of xenobiotics and play important roles in antioxidant defense. We investigated the expression patterns of seven Venerupis philippinarum GSTs (VpGSTs) and four Mytilus galloprovincialis GSTs (MgGSTs) following exposure to BDE-47. Differential expressions of the seven VpGSTs and four Mg GSTs transcripts were observed, with differences between the hepatopancreas and gills. Among these GSTs, the sigma classes (VpGSTS1, VpGSTS2, VpGSTS3, MgGST1, and MgGST3) were highly expressed in response to BDE-47 exposure, demonstrating their potential as molecular biomarkers for environmental biomonitoring studies. We obtained the three-dimensional crystal structures of VpGSTs and MgGSTs by homologous modeling. A model to elucidate the binding interactions between the ligands and receptors was defined by molecular docking. Hydrophobic and pi were the most often observed interactions between BDE-47 and the GSTs. |
文章类型 | 期刊论文 |
资助机构 | Marine & Freshwater Biology ; Oceanography |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | POLYBROMINATED DIPHENYL ETHERS ; OMEGA-CLASS ; VENERUPIS-PHILIPPINARUM ; NORTH CHINA ; FETAL BLOOD ; BOHAI BAY ; IN-VITRO ; MU-CLASS ; CLONING ; HYDROCARBONS |
研究领域[WOS] | National Natural Science Foundation of China [21107136] ; International Foundation for Science [F/5230-1] |
WOS记录号 | WOS:000353891400016 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/8624 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn |
推荐引用方式 GB/T 7714 | Li Fei,Wu Huifeng,Wang Qing,et al. Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2015,33(3):705-713. |
APA | Li Fei,Wu Huifeng,Wang Qing,Li Xuehua,Zhao Jianmin,&Wu, HF .(2015).Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,33(3),705-713. |
MLA | Li Fei,et al."Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 33.3(2015):705-713. |
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