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题名:
Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms
作者: Li, Fei(李斐) ; Wu Huifeng ; Wang, Qing(王清) ; Li Xuehua ; Zhao Jianmin
刊名: CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN号: 0254-4059
出版日期: 2015-05
卷号: 33, 期号:3, 页码:705-713
关键词: glutathione S-transferase (GST) ; Venerupis philippinarum ; Mytilus galloprovincialis ; 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE-47) ; molecular docking ; biomarker
学科分类: Limnology; Oceanography
DOI: 10.1007/s00343-015-4127-5
产权排序: [Li Fei; Wu Huifeng; Wang Qing; Zhao Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Li Xuehua] Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn MOE, Dalian 116024, Peoples R China
通讯作者: Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
作者部门: 中科院海岸带环境过程与生态修复重点实验室
中文摘要: Glutathione S-transferases (GSTs) are phase II enzymes that facilitate the detoxification of xenobiotics and play important roles in antioxidant defense. We investigated the expression patterns of seven Venerupis philippinarum GSTs (VpGSTs) and four Mytilus galloprovincialis GSTs (MgGSTs) following exposure to BDE-47. Differential expressions of the seven VpGSTs and four Mg GSTs transcripts were observed, with differences between the hepatopancreas and gills. Among these GSTs, the sigma classes (VpGSTS1, VpGSTS2, VpGSTS3, MgGST1, and MgGST3) were highly expressed in response to BDE-47 exposure, demonstrating their potential as molecular biomarkers for environmental biomonitoring studies. We obtained the three-dimensional crystal structures of VpGSTs and MgGSTs by homologous modeling. A model to elucidate the binding interactions between the ligands and receptors was defined by molecular docking. Hydrophobic and pi were the most often observed interactions between BDE-47 and the GSTs.
研究领域[WOS]: National Natural Science Foundation of China [21107136] ; International Foundation for Science [F/5230-1]
项目资助者: Marine & Freshwater Biology ; Oceanography
关键词[WOS]: POLYBROMINATED DIPHENYL ETHERS ; OMEGA-CLASS ; VENERUPIS-PHILIPPINARUM ; NORTH CHINA ; FETAL BLOOD ; BOHAI BAY ; IN-VITRO ; MU-CLASS ; CLONING ; HYDROCARBONS
文章类型: 期刊论文
收录类别: SCI
语种: 英语
WOS记录号: WOS:000353891400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/8624
Appears in Collections:中科院海岸带环境过程与生态修复重点实验室_期刊论文

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Recommended Citation:
Li Fei,Wu Huifeng,Wang Qing,et al. Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2015,33(3):705-713.
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文件名: Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms.pdf
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