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Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms
Li Fei; Wu Huifeng; Wang Qing; Li Xuehua; Zhao Jianmin; Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
Source PublicationCHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
2015-05
Volume33Issue:3Pages:705-713
KeywordGlutathione S-transferase (Gst) Venerupis Philippinarum Mytilus Galloprovincialis Molecular Docking 2 Biomarker 2 ' 4 4 '-tetrabromodiphenyl Ether (Bde-47)
DOI10.1007/s00343-015-4127-5
Contribution Rank[Li Fei; Wu Huifeng; Wang Qing; Zhao Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Li Xuehua] Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn MOE, Dalian 116024, Peoples R China
Department中科院海岸带环境过程与生态修复重点实验室
AbstractGlutathione S-transferases (GSTs) are phase II enzymes that facilitate the detoxification of xenobiotics and play important roles in antioxidant defense. We investigated the expression patterns of seven Venerupis philippinarum GSTs (VpGSTs) and four Mytilus galloprovincialis GSTs (MgGSTs) following exposure to BDE-47. Differential expressions of the seven VpGSTs and four Mg GSTs transcripts were observed, with differences between the hepatopancreas and gills. Among these GSTs, the sigma classes (VpGSTS1, VpGSTS2, VpGSTS3, MgGST1, and MgGST3) were highly expressed in response to BDE-47 exposure, demonstrating their potential as molecular biomarkers for environmental biomonitoring studies. We obtained the three-dimensional crystal structures of VpGSTs and MgGSTs by homologous modeling. A model to elucidate the binding interactions between the ligands and receptors was defined by molecular docking. Hydrophobic and pi were the most often observed interactions between BDE-47 and the GSTs.
Subtype期刊论文
Indexed BySCI
Language英语
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; OMEGA-CLASS ; VENERUPIS-PHILIPPINARUM ; NORTH CHINA ; FETAL BLOOD ; BOHAI BAY ; IN-VITRO ; MU-CLASS ; CLONING ; HYDROCARBONS
WOS Research AreaNational Natural Science Foundation of China [21107136] ; International Foundation for Science [F/5230-1]
WOS IDWOS:000353891400016
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/8624
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorWu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
Recommended Citation
GB/T 7714
Li Fei,Wu Huifeng,Wang Qing,et al. Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2015,33(3):705-713.
APA Li Fei,Wu Huifeng,Wang Qing,Li Xuehua,Zhao Jianmin,&Wu, HF .(2015).Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,33(3),705-713.
MLA Li Fei,et al."Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 33.3(2015):705-713.
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