Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms
Li Fei; Wu Huifeng; Wang Qing; Li Xuehua; Zhao Jianmin; Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
2015-05
发表期刊CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
卷号33期号:3页码:705-713
产权排序[Li Fei; Wu Huifeng; Wang Qing; Zhao Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Li Xuehua] Dalian Univ Technol, Sch Environm Sci & Technol, Key Lab Ind Ecol & Environm Engn MOE, Dalian 116024, Peoples R China
摘要Glutathione S-transferases (GSTs) are phase II enzymes that facilitate the detoxification of xenobiotics and play important roles in antioxidant defense. We investigated the expression patterns of seven Venerupis philippinarum GSTs (VpGSTs) and four Mytilus galloprovincialis GSTs (MgGSTs) following exposure to BDE-47. Differential expressions of the seven VpGSTs and four Mg GSTs transcripts were observed, with differences between the hepatopancreas and gills. Among these GSTs, the sigma classes (VpGSTS1, VpGSTS2, VpGSTS3, MgGST1, and MgGST3) were highly expressed in response to BDE-47 exposure, demonstrating their potential as molecular biomarkers for environmental biomonitoring studies. We obtained the three-dimensional crystal structures of VpGSTs and MgGSTs by homologous modeling. A model to elucidate the binding interactions between the ligands and receptors was defined by molecular docking. Hydrophobic and pi were the most often observed interactions between BDE-47 and the GSTs.
关键词Glutathione S-transferase (Gst) Venerupis Philippinarum Mytilus Galloprovincialis Molecular Docking 2 Biomarker 2 ' 4 4 '-tetrabromodiphenyl Ether (Bde-47)
作者部门中科院海岸带环境过程与生态修复重点实验室
学科领域Limnology ; Oceanography
DOI10.1007/s00343-015-4127-5
项目资助者Marine & Freshwater Biology ; Oceanography
收录类别SCI
关键词[WOS]POLYBROMINATED DIPHENYL ETHERS ; OMEGA-CLASS ; VENERUPIS-PHILIPPINARUM ; NORTH CHINA ; FETAL BLOOD ; BOHAI BAY ; IN-VITRO ; MU-CLASS ; CLONING ; HYDROCARBONS
文章类型期刊论文
语种英语
WOS研究方向National Natural Science Foundation of China [21107136] ; International Foundation for Science [F/5230-1]
WOS记录号WOS:000353891400016
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/8624
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
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Li Fei,Wu Huifeng,Wang Qing,et al. Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2015,33(3):705-713.
APA Li Fei,Wu Huifeng,Wang Qing,Li Xuehua,Zhao Jianmin,&Wu, HF .(2015).Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,33(3),705-713.
MLA Li Fei,et al."Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 33.3(2015):705-713.
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