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Critical features identification for chemical chronic toxicity based on mechanistic forecast models 期刊论文
ENVIRONMENTAL POLLUTION, 2022, 卷号: 307, 页码: 8
作者:  Wang, Xiaoqing;  Li, Fei;  Chen, Jingwen;  Teng, Yuefa;  Ji, Chenglong;  Wu, Huifeng
收藏  |  浏览/下载：270/0  |  提交时间：2022/07/26
Computational toxicology  Machine learning  Structural alerts  Risk assessment  Prioritization rank  
Toxicity pathways of lipid metabolic disorders induced by typical replacement flame retardants via data-driven analysis, in silico and in vitro approaches 期刊论文
CHEMOSPHERE, 2022, 卷号: 287, 页码: 9
作者:  Wang, Xiaoqing;  Wang, Li;  Li, Fei;  Teng, Yuefa;  Ji, Chenglong;  Wu, Huifeng
收藏  |  浏览/下载：267/0  |  提交时间：2022/06/16
Toxicity pathways  Lipid metabolism disorder  Bibliometric analysis  Computational toxicology  Data-driven analysis  
Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 卷号: 227, 页码: 8
作者:  Li, Fei;  Meng, Xiangjing;  Wang, Xiaoqing;  Ji, Chenglong;  Wu, Huifeng
收藏  |  浏览/下载：250/0  |  提交时间：2022/06/16
Nanomaterials  Graphene  Organophosphorus ester (OPEs)  Mytilus  Joint effects  Multi-omics  
Integration of Computational Toxicology, Toxicogenomics Data Mining, and Omics Techniques to Unveil Toxicity Pathways 期刊论文
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, 卷号: 9, 期号: 11, 页码: 4130-4138
作者:  Wang, Xiaoqing;  Li, Fei;  Chen, Jingwen;  Ji, Chenglong;  Wu, Huifeng
浏览  |  Adobe PDF(3938Kb)  |  收藏  |  浏览/下载：767/298  |  提交时间：2021/05/22
Adverse outcome pathway (AOP)  Comparative toxicogenomics database (CTD)  Triphenyl phosphate (TPP)  Molecular dynamics (MD)  Transcriptome analyses  
iTRAQ-based proteomic analysis on the mitochondrial responses in gill tissues of juvenile olive flounder Paralichthys olivaceus exposed to cadmium 期刊论文
ENVIRONMENTAL POLLUTION, 2020, 卷号: 257, 页码: 113591
作者:  Lu, Z;  Wang, S;  Ji, CL;  Li, F;  Cong, M;  Shan, XJ;  Wu, HF
浏览  |  Adobe PDF(2097Kb)  |  收藏  |  浏览/下载：741/386  |  提交时间：2020/07/08
Cadmium  Paralichthys olivaceus  iTRAQ  Proteomics  Mitochondrial toxicity  
Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms 期刊论文
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2015, 卷号: 33, 期号: 3, 页码: 705-713
作者:  Li Fei;  Wu Huifeng;  Wang Qing;  Li Xuehua;  Zhao Jianmin;  Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(580Kb)  |  收藏  |  浏览/下载：887/297  |  提交时间：2015/07/31
Glutathione S-transferase (Gst)  Venerupis Philippinarum  Mytilus Galloprovincialis  Molecular Docking  2  Biomarker  2 '  4  4 '-tetrabromodiphenyl Ether (Bde-47)  
Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study 期刊论文
TOXICOLOGY LETTERS, 2015, 卷号: 232, 期号: 2, 页码: 533-541
作者:  Li, Fei;  Cao, Lulu;  Li, Xuehua;  Li, Na;  Wang, Zijian;  Wu, Huifeng;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(2093Kb)  |  收藏  |  浏览/下载：835/295  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs)  P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Partial Least Squares (Pls)  
Determination and Prediction of the Binding Interaction between Organophosphate Flame Retardants and p53 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2014, 卷号: 27, 期号: 11, 页码: 1918-1925
作者:  Li, Fei;  Yang, Xianhai;  Li, Xuehua;  Li, Renmin;  Zhao, Jianmin;  Wu, Huifeng;  Li, F (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. fli@yic.ac.cn;  hfwu@yic.ac.cn
浏览  |  Adobe PDF(1104Kb)  |  收藏  |  浏览/下载：873/392  |  提交时间：2015/07/31
Polybrominated Diphenyl Ethers  Thyroid-hormone Receptors  Structural Requirements  Surface Waters  In-silico  Plasticizers  Complex  Air  Regression  Zebrafish  
Docking and QSAR study on the binding interactions between polycyclic aromatic hydrocarbons and estrogen receptor 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2012, 卷号: 80, 页码: 273-279
作者:  Li, Fei;  Wu, Huifeng;  Li, Lianzhen;  Li, Xuehua;  Zhao, Jianmin;  Peijnenburg, Willie J. G. M.
浏览  |  Adobe PDF(450Kb)  |  收藏  |  浏览/下载：1113/432  |  提交时间：2013/03/08
Polycyclic Aromatic Hydrocarbons (Pahs)  Estrogenic Activity  Molecular Docking  Quantitative Structure-activity Relationship (Qsar)  Applicability Domain  
Docking and 3D-QSAR studies on the Ah receptor binding affinities of polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) 期刊论文
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2011, 卷号: 32, 期号: 3, 页码: 478-485
作者:  Li, Fei;  Li, Xuehua;  Liu, Xiaoli;  Zhang, Linbao;  You, Liping;  Zhao, Jianmin;  Wu, Huifeng
浏览  |  Adobe PDF(398Kb)  |  收藏  |  浏览/下载：2006/599  |  提交时间：2012/03/06
Qsar  Docking  Partial Least Squares  Polychlorinated Biphenyls (Pcbs)  Dibenzo-p-dioxins (Pcdds)  Dibenzofurans (Pcdfs)