Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics

	Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics
	Zhang, Linbao 1,2; Liu, Xiaoli 1,2; You, Liping 1,2; Zhou, Di1,2 ; Wang, Qing1 ; Li, Fei1 ; Cong, Ming1 ; Li, Lianzhen1 ; Zhao, Jianmin1 ; Liu, Dongyan1 ; Yu, Junbao1 ; Wu, Huifeng1
发表期刊	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2011-09-01
卷号	32 期号:2 页码:218-225
关键词	Benzo(a)Pyrene Toxicological Effects Biomarker Manila Clam Nmr Metabolomics
英文摘要	Benzo(a)pyrene is an important polycyclic aromatic hydrocarbon (PAH) which causes carcinogenic, teratogenic and mutagenic effects in various species and the level of contamination of this toxic agent in the marine environment is of great concern. In this study, metabolic responses induced by two doses (0.02 and 0.2 mu M) of BaP were characterized in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48 and 96h. The high dose (0.2 mu M) of BaP induced the disturbances in energy metabolism and osmotic regulation based on the metabolic biomarkers such as succinate, alanine, glucose, glycogen, branched chain amino acids, betaine, taurine, homarine, and dimethylamine in clam gills after 24 h of exposure. In addition, hormesis induced by BaP was found in clams exposed to both doses of BaP. Overall, our results demonstrated the applicability of metabolomics for the elucidation of toxicological effects of marine environmental contaminants in a selected bioindicator species such as the Manila clam. (C) 2011 Elsevier B.V. All rights reserved.
文章类型	Article
收录类别	SCI
语种	英语
关键词[WOS]	PATTERN-RECOGNITION ; NMR METABOLOMICS ; TIDAL FLATS ; LIVER ; SPECTROSCOPY ; METABONOMICS ; EXTRACTION ; TRANSFORMATION ; VITELLOGENIN ; BIOCHEMISTRY
研究领域[WOS]	Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000294936700014
引用统计	被引频次：85[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/9249
专题	中国科学院海岸带环境过程与生态修复重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室中国科学院海岸带环境过程与生态修复重点实验室_滨海湿地实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2011,32(2):218-225.
APA	Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Wang, Qing.,...&Wu, Huifeng.(2011).Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,32(2),218-225.
MLA	Zhang, Linbao,et al."Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 32.2(2011):218-225.