YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics
Zhang, Linbao1,2; Liu, Xiaoli1,2; You, Liping1,2; Zhou, Di1,2; Wang, Qing1; Li, Fei1; Cong, Ming1; Li, Lianzhen1; Zhao, Jianmin1; Liu, Dongyan1; Yu, Junbao1; Wu, Huifeng1
2011-09-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume32Issue:2Pages:218-225
AbstractBenzo(a)pyrene is an important polycyclic aromatic hydrocarbon (PAH) which causes carcinogenic, teratogenic and mutagenic effects in various species and the level of contamination of this toxic agent in the marine environment is of great concern. In this study, metabolic responses induced by two doses (0.02 and 0.2 mu M) of BaP were characterized in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48 and 96h. The high dose (0.2 mu M) of BaP induced the disturbances in energy metabolism and osmotic regulation based on the metabolic biomarkers such as succinate, alanine, glucose, glycogen, branched chain amino acids, betaine, taurine, homarine, and dimethylamine in clam gills after 24 h of exposure. In addition, hormesis induced by BaP was found in clams exposed to both doses of BaP. Overall, our results demonstrated the applicability of metabolomics for the elucidation of toxicological effects of marine environmental contaminants in a selected bioindicator species such as the Manila clam. (C) 2011 Elsevier B.V. All rights reserved.
KeywordBenzo(a)Pyrene Toxicological Effects Biomarker Manila Clam Nmr Metabolomics
Indexed BySCI
WOS KeywordPATTERN-RECOGNITION ; NMR METABOLOMICS ; TIDAL FLATS ; LIVER ; SPECTROSCOPY ; METABONOMICS ; EXTRACTION ; TRANSFORMATION ; VITELLOGENIN ; BIOCHEMISTRY
SubtypeArticle
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000294936700014
Citation statistics
Cited Times:74[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/9249
Collection中科院海岸带环境过程与生态修复重点实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2011,32(2):218-225.
APA Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Wang, Qing.,...&Wu, Huifeng.(2011).Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,32(2),218-225.
MLA Zhang, Linbao,et al."Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance (H-1 NMR) based metabolomics".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 32.2(2011):218-225.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Linbao]'s Articles
[Liu, Xiaoli]'s Articles
[You, Liping]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Linbao]'s Articles
[Liu, Xiaoli]'s Articles
[You, Liping]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Linbao]'s Articles
[Liu, Xiaoli]'s Articles
[You, Liping]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.