YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities
Wu, Huifeng1,2; Zhang, Xingyan1,2,3; Wang, Qing1,2; Li, Lianzhen1,2; Ji, Chenglong1,2,3; Liu, Xiaoli1,2,3; Zhao, Jianmin1,2; Yin, Xiuli1,2
2013-04-01
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
Volume90Pages:1-6
Contribution Rank[Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli] YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Zhang, Xingyan; Ji, Chenglong; Liu, Xiaoli] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
AbstractArsenic is an important contaminant in the Bohai marine ecosystem due to the anthropogenic activities. In this work, we investigated the toxicological effects of arsenic in Ruditapes philippinarum under different seawater salinities using NMR-based metabolomics. Under normal salinity (31.1 ppt), arsenic decreased the levels of amino acids (glutamate, beta-alanine, etc.), and increased the levels of betaine and fumarate. The metabolic biomarkers including decreased threonine, histidine, ATP and fumarate were found in the muscles of arsenic-treated clams under medium salinity (23.3 ppt). However, only elevated ATP and depleted succinate were detected in the arsenic-exposed clam samples under low salinity (15.6 ppt). These differential metabolic biomarkers indicated that arsenic could induce osmotic stress and disturbance in energy metabolism in clam under normal and medium salinities. However, arsenic caused only disturbance in energy metabolism in clam under low salinity. Overall, our results demonstrated that seawater salinity could influence the toxicological effects of arsenic. (C) 2012 Elsevier Inc. All rights reserved.; Arsenic is an important contaminant in the Bohai marine ecosystem due to the anthropogenic activities. In this work, we investigated the toxicological effects of arsenic in Ruditapes philippinarum under different seawater salinities using NMR-based metabolomics. Under normal salinity (31.1 ppt), arsenic decreased the levels of amino acids (glutamate, beta-alanine, etc.), and increased the levels of betaine and fumarate. The metabolic biomarkers including decreased threonine, histidine, ATP and fumarate were found in the muscles of arsenic-treated clams under medium salinity (23.3 ppt). However, only elevated ATP and depleted succinate were detected in the arsenic-exposed clam samples under low salinity (15.6 ppt). These differential metabolic biomarkers indicated that arsenic could induce osmotic stress and disturbance in energy metabolism in clam under normal and medium salinities. However, arsenic caused only disturbance in energy metabolism in clam under low salinity. Overall, our results demonstrated that seawater salinity could influence the toxicological effects of arsenic. (C) 2012 Elsevier Inc. All rights reserved.
Corresponding AuthorWu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
KeywordRuditapes Philippinarum Arsenic Toxicological Effects Nmr Metabolomics
Department中科院海岸带环境过程与生态修复重点实验室
Subject AreaEnvironmental Sciences ; Toxicology
Funding OrganizationNSFC [41106102]; SDSFC [ZR2009CZ008]; The 100 Talents Program of the Chinese Academy of Sciences
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Indexed BySCI
WOS KeywordNMR-BASED METABOLOMICS ; MAGNETIC-RESONANCE-SPECTROSCOPY ; H-1-NMR METABOLOMICS ; PATTERN-RECOGNITION ; TAPES-PHILIPPINARUM ; OXIDATIVE STRESS ; MANILA CLAMS ; RESPONSES ; METABONOMICS ; TRANSFORMATION
SubtypeArticle
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS IDWOS:000315840000001
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/6590
Collection中科院海岸带环境过程与生态修复重点实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China
2.YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wu, Huifeng,Zhang, Xingyan,Wang, Qing,et al. A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2013,90:1-6.
APA Wu, Huifeng.,Zhang, Xingyan.,Wang, Qing.,Li, Lianzhen.,Ji, Chenglong.,...&Yin, Xiuli.(2013).A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,90,1-6.
MLA Wu, Huifeng,et al."A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 90(2013):1-6.
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