A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities
Wu, Huifeng1,2; Zhang, Xingyan1,2,3; Wang, Qing1,2; Li, Lianzhen1,2; Ji, Chenglong1,2,3; Liu, Xiaoli1,2,3; Zhao, Jianmin1,2; Yin, Xiuli1,2
发表期刊ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
2013-04-01
卷号90页码:1-6
关键词Ruditapes Philippinarum Arsenic Toxicological Effects Nmr Metabolomics
产权排序[Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli] YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Zhang, Xingyan; Ji, Chenglong; Liu, Xiaoli] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
通讯作者Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
作者部门中科院海岸带环境过程与生态修复重点实验室
英文摘要Arsenic is an important contaminant in the Bohai marine ecosystem due to the anthropogenic activities. In this work, we investigated the toxicological effects of arsenic in Ruditapes philippinarum under different seawater salinities using NMR-based metabolomics. Under normal salinity (31.1 ppt), arsenic decreased the levels of amino acids (glutamate, beta-alanine, etc.), and increased the levels of betaine and fumarate. The metabolic biomarkers including decreased threonine, histidine, ATP and fumarate were found in the muscles of arsenic-treated clams under medium salinity (23.3 ppt). However, only elevated ATP and depleted succinate were detected in the arsenic-exposed clam samples under low salinity (15.6 ppt). These differential metabolic biomarkers indicated that arsenic could induce osmotic stress and disturbance in energy metabolism in clam under normal and medium salinities. However, arsenic caused only disturbance in energy metabolism in clam under low salinity. Overall, our results demonstrated that seawater salinity could influence the toxicological effects of arsenic. (C) 2012 Elsevier Inc. All rights reserved.; Arsenic is an important contaminant in the Bohai marine ecosystem due to the anthropogenic activities. In this work, we investigated the toxicological effects of arsenic in Ruditapes philippinarum under different seawater salinities using NMR-based metabolomics. Under normal salinity (31.1 ppt), arsenic decreased the levels of amino acids (glutamate, beta-alanine, etc.), and increased the levels of betaine and fumarate. The metabolic biomarkers including decreased threonine, histidine, ATP and fumarate were found in the muscles of arsenic-treated clams under medium salinity (23.3 ppt). However, only elevated ATP and depleted succinate were detected in the arsenic-exposed clam samples under low salinity (15.6 ppt). These differential metabolic biomarkers indicated that arsenic could induce osmotic stress and disturbance in energy metabolism in clam under normal and medium salinities. However, arsenic caused only disturbance in energy metabolism in clam under low salinity. Overall, our results demonstrated that seawater salinity could influence the toxicological effects of arsenic. (C) 2012 Elsevier Inc. All rights reserved.
文章类型Article
资助机构NSFC [41106102]; SDSFC [ZR2009CZ008]; The 100 Talents Program of the Chinese Academy of Sciences
收录类别SCI
语种英语
关键词[WOS]NMR-BASED METABOLOMICS ; MAGNETIC-RESONANCE-SPECTROSCOPY ; H-1-NMR METABOLOMICS ; PATTERN-RECOGNITION ; TAPES-PHILIPPINARUM ; OXIDATIVE STRESS ; MANILA CLAMS ; RESPONSES ; METABONOMICS ; TRANSFORMATION
研究领域[WOS]Environmental Sciences & Ecology ; Toxicology
WOS记录号WOS:000315840000001
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/6590
专题中国科学院海岸带环境过程与生态修复重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China
2.YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Wu, Huifeng,Zhang, Xingyan,Wang, Qing,et al. A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2013,90:1-6.
APA Wu, Huifeng.,Zhang, Xingyan.,Wang, Qing.,Li, Lianzhen.,Ji, Chenglong.,...&Yin, Xiuli.(2013).A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,90,1-6.
MLA Wu, Huifeng,et al."A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 90(2013):1-6.
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