Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities | |
Wu, Huifeng1,2; Zhang, Xingyan1,2,3; Wang, Qing1,2; Li, Lianzhen1,2; Ji, Chenglong1,2,3; Liu, Xiaoli1,2,3; Zhao, Jianmin1,2; Yin, Xiuli1,2 | |
发表期刊 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY |
ISSN | 0147-6513 |
2013-04-01 | |
卷号 | 90页码:1-6 |
关键词 | Ruditapes Philippinarum Arsenic Toxicological Effects Nmr Metabolomics |
产权排序 | [Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli] YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Zhang, Xingyan; Ji, Chenglong; Liu, Xiaoli] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn |
作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
英文摘要 | Arsenic is an important contaminant in the Bohai marine ecosystem due to the anthropogenic activities. In this work, we investigated the toxicological effects of arsenic in Ruditapes philippinarum under different seawater salinities using NMR-based metabolomics. Under normal salinity (31.1 ppt), arsenic decreased the levels of amino acids (glutamate, beta-alanine, etc.), and increased the levels of betaine and fumarate. The metabolic biomarkers including decreased threonine, histidine, ATP and fumarate were found in the muscles of arsenic-treated clams under medium salinity (23.3 ppt). However, only elevated ATP and depleted succinate were detected in the arsenic-exposed clam samples under low salinity (15.6 ppt). These differential metabolic biomarkers indicated that arsenic could induce osmotic stress and disturbance in energy metabolism in clam under normal and medium salinities. However, arsenic caused only disturbance in energy metabolism in clam under low salinity. Overall, our results demonstrated that seawater salinity could influence the toxicological effects of arsenic. (C) 2012 Elsevier Inc. All rights reserved.; Arsenic is an important contaminant in the Bohai marine ecosystem due to the anthropogenic activities. In this work, we investigated the toxicological effects of arsenic in Ruditapes philippinarum under different seawater salinities using NMR-based metabolomics. Under normal salinity (31.1 ppt), arsenic decreased the levels of amino acids (glutamate, beta-alanine, etc.), and increased the levels of betaine and fumarate. The metabolic biomarkers including decreased threonine, histidine, ATP and fumarate were found in the muscles of arsenic-treated clams under medium salinity (23.3 ppt). However, only elevated ATP and depleted succinate were detected in the arsenic-exposed clam samples under low salinity (15.6 ppt). These differential metabolic biomarkers indicated that arsenic could induce osmotic stress and disturbance in energy metabolism in clam under normal and medium salinities. However, arsenic caused only disturbance in energy metabolism in clam under low salinity. Overall, our results demonstrated that seawater salinity could influence the toxicological effects of arsenic. (C) 2012 Elsevier Inc. All rights reserved. |
文章类型 | Article |
资助机构 | NSFC [41106102]; SDSFC [ZR2009CZ008]; The 100 Talents Program of the Chinese Academy of Sciences |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | NMR-BASED METABOLOMICS ; MAGNETIC-RESONANCE-SPECTROSCOPY ; H-1-NMR METABOLOMICS ; PATTERN-RECOGNITION ; TAPES-PHILIPPINARUM ; OXIDATIVE STRESS ; MANILA CLAMS ; RESPONSES ; METABONOMICS ; TRANSFORMATION |
研究领域[WOS] | Environmental Sciences & Ecology ; Toxicology |
WOS记录号 | WOS:000315840000001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/6590 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China 2.YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Wu, Huifeng,Zhang, Xingyan,Wang, Qing,et al. A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2013,90:1-6. |
APA | Wu, Huifeng.,Zhang, Xingyan.,Wang, Qing.,Li, Lianzhen.,Ji, Chenglong.,...&Yin, Xiuli.(2013).A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,90,1-6. |
MLA | Wu, Huifeng,et al."A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 90(2013):1-6. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
A metabolomic invest(472KB) | 开放获取 | -- | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论