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An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)
Ji, CL; Li, F; Wang, Q; Zhao, JM; Sun, ZD; Wu, HF; Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
2016-02-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume144Pages:527-539
Contribution Rank[Ji, Chenglong; Li, Fei; Wang, Qing; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China; [Sun, Zuodeng] Shandong Hydrobios Resources Conservat & Manageme, Yantai 264003, Shandong, Peoples R China
AbstractTetrabromobisphenol A (TBBPA), accounting for the largest production of brominated flame-retardants (BFRs) along the Laizhou Bay in China, is of great concern due to its diverse toxicities. In this study, we focused on the gender-specific responses of TBBPA in mussel Mytilus galloprovincialis using an integrated proteomic and metabolomic approach. After exposure of TBBPA (10 mu g L-1) for one month, a total of 9 metabolites and 67 proteins were altered in mussel gills from exposed group. The significant changes of metabolites in female mussel gills from exposed group exhibited the disturbances in energy metabolism and osmotic regulation, while in male samples only be found the variation of metabolites related to osmotic regulation. iTRAQ-based proteomic analysis showed biological differences between male and female mussel gills from solvent control group. The higher levels of proteins related to primary and energy metabolism and defense mechanisms in male mussel gills meant a greater anti-stress capability of male mussels. Further analysis revealed that TBBPA exposure affected multiple biological processes consisting of production and development, material and energy metabolism, signal transduction, gene expression, defense mechanisms and apoptosis in both male and female mussels with different mechanisms. Specially, the responsive proteins of TBBPA in male mussels signified higher tolerance limits than those in female individuals, which was consistent with the biological differences between male and female mussel gills from solvent control group. This work suggested that the gender differences should be considered in ecotoxicology. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordGender-specific Mytilus Galloprovincialis Proteomics Metabolomics Tetrabromobisphenol a
Department中科院海岸带环境过程与生态修复重点实验室
DOI10.1016/j.chemosphere.2015.08.052
Funding OrganizationNational Key Basic Research Program of China(2015CB453303) ; National Science Foundation for Young Scientists of China(41506138) ; Youth Innovation Promotion Association CAS(2015169)
Indexed BySCI
WOS KeywordBROMINATED FLAME RETARDANTS ; NMR-BASED METABOLOMICS ; 2,2',4,4'-TETRABROMODIPHENYL ETHER ; MOLECULAR CHARACTERIZATION ; IN-VITRO ; PROTEINS ; GILL ; EXPRESSION ; BIOMARKERS ; APOPTOSIS
SubtypeArticle
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS IDWOS:000367774400069
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/9303
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorWu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
Affiliation1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS
2.Shandong Hydrobios Resources Conservat & Manageme
Recommended Citation
GB/T 7714
Ji, CL,Li, F,Wang, Q,et al. An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)[J]. CHEMOSPHERE,2016,144:527-539.
APA Ji, CL.,Li, F.,Wang, Q.,Zhao, JM.,Sun, ZD.,...&Wu, HF .(2016).An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA).CHEMOSPHERE,144,527-539.
MLA Ji, CL,et al."An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)".CHEMOSPHERE 144(2016):527-539.
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