Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA) | |
Ji, CL ; Li, F; Wang, Q; Zhao, JM; Sun, ZD; Wu, HF; Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
| |
| 发表期刊 | CHEMOSPHERE
 |
| ISSN | 0045-6535 |
| 2016-02-01 | |
| 卷号 | 144页码:527-539 |
| 关键词 | Gender-specific Mytilus Galloprovincialis Proteomics Metabolomics Tetrabromobisphenol a |
| DOI | 10.1016/j.chemosphere.2015.08.052 |
| 产权排序 | [Ji, Chenglong; Li, Fei; Wang, Qing; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China; [Sun, Zuodeng] Shandong Hydrobios Resources Conservat & Manageme, Yantai 264003, Shandong, Peoples R China |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | Tetrabromobisphenol A (TBBPA), accounting for the largest production of brominated flame-retardants (BFRs) along the Laizhou Bay in China, is of great concern due to its diverse toxicities. In this study, we focused on the gender-specific responses of TBBPA in mussel Mytilus galloprovincialis using an integrated proteomic and metabolomic approach. After exposure of TBBPA (10 mu g L-1) for one month, a total of 9 metabolites and 67 proteins were altered in mussel gills from exposed group. The significant changes of metabolites in female mussel gills from exposed group exhibited the disturbances in energy metabolism and osmotic regulation, while in male samples only be found the variation of metabolites related to osmotic regulation. iTRAQ-based proteomic analysis showed biological differences between male and female mussel gills from solvent control group. The higher levels of proteins related to primary and energy metabolism and defense mechanisms in male mussel gills meant a greater anti-stress capability of male mussels. Further analysis revealed that TBBPA exposure affected multiple biological processes consisting of production and development, material and energy metabolism, signal transduction, gene expression, defense mechanisms and apoptosis in both male and female mussels with different mechanisms. Specially, the responsive proteins of TBBPA in male mussels signified higher tolerance limits than those in female individuals, which was consistent with the biological differences between male and female mussel gills from solvent control group. This work suggested that the gender differences should be considered in ecotoxicology. (C) 2015 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | National Key Basic Research Program of China(2015CB453303) ; National Science Foundation for Young Scientists of China(41506138) ; Youth Innovation Promotion Association CAS(2015169) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | BROMINATED FLAME RETARDANTS ; NMR-BASED METABOLOMICS ; 2,2',4,4'-TETRABROMODIPHENYL ETHER ; MOLECULAR CHARACTERIZATION ; IN-VITRO ; PROTEINS ; GILL ; EXPRESSION ; BIOMARKERS ; APOPTOSIS |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| WOS记录号 | WOS:000367774400069 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/9303 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS 2.Shandong Hydrobios Resources Conservat & Manageme |
| 推荐引用方式 GB/T 7714 | Ji, CL,Li, F,Wang, Q,et al. An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)[J]. CHEMOSPHERE,2016,144:527-539. |
| APA | Ji, CL.,Li, F.,Wang, Q.,Zhao, JM.,Sun, ZD.,...&Wu, HF .(2016).An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA).CHEMOSPHERE,144,527-539. |
| MLA | Ji, CL,et al."An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)".CHEMOSPHERE 144(2016):527-539. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| An integrated proteo（2260KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
| 个性服务 |
| 推荐该条目 |
| 保存到收藏夹 |
| 查看访问统计 |
| 导出为Endnote文件 |
| 谷歌学术 |
| 谷歌学术中相似的文章 |
| [Ji, CL]的文章 |
| [Li, F]的文章 |
| [Wang, Q]的文章 |
| 百度学术 |
| 百度学术中相似的文章 |
| [Ji, CL]的文章 |
| [Li, F]的文章 |
| [Wang, Q]的文章 |
| 必应学术 |
| 必应学术中相似的文章 |
| [Ji, CL]的文章 |
| [Li, F]的文章 |
| [Wang, Q]的文章 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论