The present invention provides assessment and prediction of the organophosphate flame retardant to the analog biological membrane damage, which belongs to the field of ecological risk assessment strategy. Comprises the following steps : by the alternating current impedance method has determined the 16 typical OPFRs the impedance value of analog biomembrane effects, the size of the impedance value for characterizing the extent of damage to the membrane. The stepwise regression and partial least squares screening molecular descriptor and construct the QSAR model, used for explaining OPFRs analog biomembrane interaction with the micro-mechanism of action, evaluate and predict the application domain to the analog of the biomembrane OPFRs damage. QSAR model established in the present invention has good fitting goodness and robustness. The method of the invention data is easy to obtain, the cost is cheap, convenient and rapid, saves a large amount of manpower, material and the time of testing, can be accurate analysis OPFRs with the function of the membrane mechanism, for OPFRs marine monitoring and ecological risk assessment provided the basis of the theoretical data.
; 李斐
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