Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans
Sun, Tao; Wu, Huifeng; Cong, Ming; Zhan, Junfei; Li, Fei
Source PublicationAGING-US
2020-02-15
Volume12Issue:3Pages:2723-2746
KeywordLIFE-SPAN OXIDATIVE STRESS TRADE-OFFS DAF-16 ROS ANTIOXIDANT HEALTHSPAN LONGEVITY GENETICS EXERCISE
MOST Discipline CatalogueCell Biology ; Geriatrics & Gerontology
DOI10.18632/aging.102773
Contribution Rank[Sun, Tao; Wu, Huifeng; Cong, Ming; Zhan, Junfei; Li, Fei] Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China; [Sun, Tao; Wu, Huifeng; Cong, Ming; Zhan, Junfei; Li, Fei] YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China; [Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Sun, Tao; Zhan, Junfei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wu, Huifeng; Cong, Ming; Li, Fei] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
Department海岸带环境过程实验室
AbstractMild stress-induced hormesis, as a promising strategy to improve longevity and healthy aging, meets both praise and criticism. To comprehensively assess the applicability of hormesis in aging intervention, this meta-analysis was conducted focusing on the effect of hormesis on Caenorhabditis elegans. Twenty-six papers involving 198 effect size estimates met the inclusion criteria. Meta-analytic results indicated that hormesis could significantly extend the mean lifespan of C. elegans by 16.7% and 25.1% under normal and stress culture conditions (p < 0.05), respectively. The healthspan assays showed that hormesis remarkably enhanced the bending frequency and pumping rate of worms by 28.9% and 7.0% (p < 0.05), respectively, while effectively reduced the lipofuscin level by 15.9% (p < 0.05). The obviously increased expression of dauer formation protein-16 (1.66-fold) and its transcriptional targets, including superoxide dismutase-3 (2.46-fold), catalase-1 (2.32-fold) and small heat shock protein-16.2 (2.88-fold) (p < 0.05), was one of the molecular mechanisms underlying these positive effects of hormesis. This meta-analysis provided strong evidence for the anti-aging role of hormesis, highlighting its lifespan-prolonging, healthspan-enhancing and resistance-increasing effects on C. elegans. Given that dauer formation protein-16 was highly conservative, hormesis offered the theoretical possibility of delaying intrinsic aging through exogenous intervention among humans.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordLIFE-SPAN ; OXIDATIVE STRESS ; TRADE-OFFS ; DAF-16 ; ROS ; ANTIOXIDANT ; HEALTHSPAN ; LONGEVITY ; GENETICS ; EXERCISE
WOS IDWOS:000514798700044
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/25087
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
Affiliation1.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China;
2.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China;
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China;
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Sun, Tao,Wu, Huifeng,Cong, Ming,et al. Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans[J]. AGING-US,2020,12(3):2723-2746.
APA Sun, Tao,Wu, Huifeng,Cong, Ming,Zhan, Junfei,&Li, Fei.(2020).Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans.AGING-US,12(3),2723-2746.
MLA Sun, Tao,et al."Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans".AGING-US 12.3(2020):2723-2746.
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