Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans | |
Sun, Tao; Wu, Huifeng ; Cong, Ming; Zhan, Junfei; Li, Fei
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| 发表期刊 | AGING-US
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| ISSN | 1945-4589 |
| 2020-02-15 | |
| 卷号 | 12期号:3页码:2723-2746 |
| 关键词 | LIFE-SPAN OXIDATIVE STRESS TRADE-OFFS DAF-16 ROS ANTIOXIDANT HEALTHSPAN LONGEVITY GENETICS EXERCISE |
| 研究领域 | Cell Biology ; Geriatrics & Gerontology |
| DOI | 10.18632/aging.102773 |
| 产权排序 | [Sun, Tao; Wu, Huifeng; Cong, Ming; Zhan, Junfei; Li, Fei] Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China; [Sun, Tao; Wu, Huifeng; Cong, Ming; Zhan, Junfei; Li, Fei] YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China; [Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Sun, Tao; Zhan, Junfei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wu, Huifeng; Cong, Ming; Li, Fei] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China |
| 通讯作者 | Wu, Huifeng(hfwu@yic.ac.cn) ; Li, Fei(fli@yic.ac.cn) |
| 作者部门 | 海岸带环境过程实验室 |
| 英文摘要 | Mild stress-induced hormesis, as a promising strategy to improve longevity and healthy aging, meets both praise and criticism. To comprehensively assess the applicability of hormesis in aging intervention, this meta-analysis was conducted focusing on the effect of hormesis on Caenorhabditis elegans. Twenty-six papers involving 198 effect size estimates met the inclusion criteria. Meta-analytic results indicated that hormesis could significantly extend the mean lifespan of C. elegans by 16.7% and 25.1% under normal and stress culture conditions (p < 0.05), respectively. The healthspan assays showed that hormesis remarkably enhanced the bending frequency and pumping rate of worms by 28.9% and 7.0% (p < 0.05), respectively, while effectively reduced the lipofuscin level by 15.9% (p < 0.05). The obviously increased expression of dauer formation protein-16 (1.66-fold) and its transcriptional targets, including superoxide dismutase-3 (2.46-fold), catalase-1 (2.32-fold) and small heat shock protein-16.2 (2.88-fold) (p < 0.05), was one of the molecular mechanisms underlying these positive effects of hormesis. This meta-analysis provided strong evidence for the anti-aging role of hormesis, highlighting its lifespan-prolonging, healthspan-enhancing and resistance-increasing effects on C. elegans. Given that dauer formation protein-16 was highly conservative, hormesis offered the theoretical possibility of delaying intrinsic aging through exogenous intervention among humans. |
| 文章类型 | Article |
| 资助机构 | Young Taishan Scholars Program of Shandong Province [tsqn201812115] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21677173] ; Youth Innovation Promotion Association CAS [2017255] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | LIFE-SPAN ; OXIDATIVE STRESS ; TRADE-OFFS ; DAF-16 ; ROS ; ANTIOXIDANT ; HEALTHSPAN ; LONGEVITY ; GENETICS ; EXERCISE |
| 研究领域[WOS] | Cell Biology ; Geriatrics & Gerontology |
| WOS记录号 | WOS:000514798700044 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/25087 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China; 2.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China; 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Tao,Wu, Huifeng,Cong, Ming,et al. Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans[J]. AGING-US,2020,12(3):2723-2746. |
| APA | Sun, Tao,Wu, Huifeng,Cong, Ming,Zhan, Junfei,&Li, Fei.(2020).Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans.AGING-US,12(3),2723-2746. |
| MLA | Sun, Tao,et al."Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans".AGING-US 12.3(2020):2723-2746. |
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