Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum | |
Hu, GG; Han, YJ; Yang, DL![]() ![]() ![]() ![]() ![]() ![]() | |
发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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ISSN | 1050-4648 |
2019-05 | |
卷号 | 88页码:556-566 |
关键词 | FADD Ruditapes philippinarum NF-kappa B Apoptosis |
研究领域 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
DOI | 10.1016/j.fsi.2019.03.033 |
产权排序 | [Hu, Gege; Han, Yijing; Yang, Dinglong; Cao, Ruiwen; Wang, Qing; Liu, Hui; Dong, Zhijun; Zhang, Xiaoli; Zhang, Qianqian; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China; [Yang, Dinglong; Wang, Qing; Liu, Hui; Dong, Zhijun; Zhang, Xiaoli; Zhang, Qianqian; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Peoples R China; [Zhao, Jianmin] Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China; [Hu, Gege; Han, Yijing; Cao, Ruiwen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
通讯作者 | Yang, Dinglong(dlyang@yic.ac.cn) ; Zhao, Jianmin(jmzhao@yic.ac.cn) |
作者部门 | 海岸带生物资源高效利用研究与发展中心 |
英文摘要 | Fas-associated protein with death domain (FADD) is an essential element in cell death, and also implicates in cell cycle progression, inflammation and innate immunity. In the study, an FADD (designated as RpFADD) was identified and characterized from manila clam, Ruditapes philippinarum. Multiple alignments and phylogenetic analysis strongly suggested that RpFADD was a new member of the FADD family. The RpFADD transcripts were constitutively expressed in a wide range of tissues, and dominantly expressed in hemocytes. After challenged with Vibrio anguillarum or Micrococcus luteus, the expression level of RpFADD transcripts was significantly induced and reached the maximum level at 72 h and 48 h, respectively. Knockdown of RpFADD down-regulated the transcript levels of Rp1KK, RpTAK1 and RpNF-kappa B with the exception of RpI kappa B. Moreover, RpFADD primarily localized in the cell cytoplasm, and its over-expression promoted the apoptosis of HeLa cells. These results revealed that RpFADD perhaps regulated the NF-kappa B signaling pathways positively, which provided a better understanding of RpFADD in innate immunity. |
文章类型 | Article |
资助机构 | Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA23050303] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41806196] ; Youth Innovation Promotion Association CAS [2016196] |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | NF-KAPPA-B ; DEATH DOMAIN ; EXPRESSION ; PROTEIN ; FAS ; ASSOCIATION ; ACTIVATION ; FLICE |
研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS记录号 | WOS:000465060500065 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/24949 |
专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室 支撑部门_中国科学院牟平海岸带环境综合试验站 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Peoples R China; 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Hu, GG,Han, YJ,Yang, DL,et al. Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum[J]. FISH & SHELLFISH IMMUNOLOGY,2019,88:556-566. |
APA | Hu, GG.,Han, YJ.,Yang, DL.,Cao, RW.,Wang, Q.,...&Zhao, JM.(2019).Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum.FISH & SHELLFISH IMMUNOLOGY,88,556-566. |
MLA | Hu, GG,et al."Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum".FISH & SHELLFISH IMMUNOLOGY 88(2019):556-566. |
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