Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| iTRAQ-based proteomic analysis on the mitochondrial responses in gill tissues of juvenile olive flounder Paralichthys olivaceus exposed to cadmium | |
Lu, Z; Wang, S; Ji, CL ; Li, F; Cong, M; Shan, XJ; Wu, HF
| |
| 发表期刊 | ENVIRONMENTAL POLLUTION
 |
| ISSN | 0269-7491 |
| 2020-02 | |
| 卷号 | 257页码:113591 |
| 关键词 | Cadmium Paralichthys olivaceus iTRAQ Proteomics Mitochondrial toxicity |
| 研究领域 | Environmental Sciences |
| DOI | 10.1016/j.envpol.2019.113591 |
| 产权排序 | [Lu, Zhen; Wang, Shuang; Ji, Chenglong; Li, Fei; Cong, Ming; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China; [Ji, Chenglong; Shan, Xiujuan] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Lu, Zhen; Wang, Shuang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Wu, Huifeng(hfwu@yic.ac.cn) |
| 作者部门 | 海岸带环境过程实验室 |
| 英文摘要 | Cadmium (Cd) is an important heavy metal pollutant in the Bohai Sea. Mitochondria are recognized as the key target for Cd toxicity. However, mitochondria! responses to Cd have not been fully investigated in marine fishes. In this study, the mitochondrial responses were characterized in gills of juvenile flounder Paralichthys olivaceus treated with two environmentally relevant concentrations (5 and 50 mu g/L) of Cd for 14 days by determination of mitochondrial membrane potential (MMP), observation of mitochondrial morphology and quantitative proteomic analysis. Both Cd treatments significantly decreased MMPs of mitochondria from flounder gills. Mitochondrial morphologies were altered in Cd-treated flounder samples, indicated by more and smaller mitochondria. iTRAQ-based proteomic analysis indicated that a total of 128 proteins were differentially expressed in both Cd treatments. These proteins were basically involved in various biological processes in gill mitochondria, including mitochondrial morphology and import, tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), primary bile acid biosynthesis, stress resistance and apoptosis. These results indicated that dynamic regulations of energy homeostasis, cholesterol metabolism, stress resistance, apoptosis, and mitochondrial morphology in gill mitochondria might play significant roles in response to Cd toxicity. Overall, this study provided a global view on mitochondrial toxicity of Cd in flounder gills using iTRAQ-based proteomics. (C) 2019 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | NSFCNational Natural Science Foundation of China [41676114] ; Young Taishan Scholars Program of Shandong Province [tsqn201812115] ; Qingdao National Laboratory for Marine Science and Technology [QNLM201701] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | VIRGINICA GMELIN BIVALVIA ; BILE-ACID SYNTHESIS ; ENERGY-METABOLISM ; ROS PRODUCTION ; COMPLEX-II ; PROTEIN ; MITOFILIN ; ACCUMULATION ; TARGET ; SAM50 |
| 研究领域[WOS] | Environmental Sciences |
| WOS记录号 | WOS:000514746800091 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24756 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China; 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Z,Wang, S,Ji, CL,et al. iTRAQ-based proteomic analysis on the mitochondrial responses in gill tissues of juvenile olive flounder Paralichthys olivaceus exposed to cadmium[J]. ENVIRONMENTAL POLLUTION,2020,257:113591. |
| APA | Lu, Z.,Wang, S.,Ji, CL.,Li, F.,Cong, M.,...&Wu, HF.(2020).iTRAQ-based proteomic analysis on the mitochondrial responses in gill tissues of juvenile olive flounder Paralichthys olivaceus exposed to cadmium.ENVIRONMENTAL POLLUTION,257,113591. |
| MLA | Lu, Z,et al."iTRAQ-based proteomic analysis on the mitochondrial responses in gill tissues of juvenile olive flounder Paralichthys olivaceus exposed to cadmium".ENVIRONMENTAL POLLUTION 257(2020):113591. |
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