Dose-dependent effects induced by cadmium in polychaete Perinereis aibuhitensis
Liu, Feng; Lu, Zhen; Wu, Huifeng; Ji, Chenglong
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
2019-03
Volume169Pages:714-721
KeywordCadmium Dose-dependent Toxicological effects Hormesis Perinereis aibuhitensis
MOST Discipline CatalogueEnvironmental Sciences & Ecology ; Toxicology
DOI10.1016/j.ecoenv.2018.11.098
Contribution Rank[Liu, Feng] China Agr Univ, Yantai Res Inst, Ocean Coll, Yantai 264670, Peoples R China; [Lu, Zhen; Wu, Huifeng; Ji, Chenglong] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China; [Lu, Zhen; Wu, Huifeng; Ji, Chenglong] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Lu, Zhen; Wu, Huifeng; Ji, Chenglong] YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
Department海岸带环境过程实验室
AbstractCadmium is a known metal contaminant in the Bohai Sea. In this study, the dose-dependent responses induced by Cd were characterized in marine polychaete Perinereis aibuhitensis using the endpoints, including activities of enzymes, expression levels of stress-responsive genes and metabolic responses. Both enzyme activities and gene expression levels exhibited the hormetic effects induced by Cd in P. aibuhitensis, as shown by the typical U-shaped or inverted U-shaped response profiles. The highest concentration (1280 mu g/L) of Cd exposure induced obvious oxidative stresses. NMR-based metabolomics revealed that Cd induced both linear dose-dependent effects (69.13% of the total variation) and a relatively slight hormesis (5.54% of the total variation) in energy metabolism in P. aibuhitensis at metabolite level. In details, Cd exposures linearly reduced the consumption of amino acids and enhanced the consumption of glucose for energy supply, resulting in elevated contents of amino acids and depleted contents of glucose. Additionally, Cd treatments induced hormesis in the conversion of ATP hydrolysis to AMP. This work suggested that the hormetic effects should be considered in the ecological risk assessment for the environmental pollutants.
Funding OrganizationNational Natural Science Foundation of China [41676114] ; National Key Basic Research Program of China [2015CB453303] ; Qingdao National Laboratory for Marine Science and Technology [QNLM201701] ; Youth Innovation Promotion Association CAS [2015169]
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordSHRIMP CRANGON-AFFINIS ; METABOLIC-RESPONSES ; METAL POLLUTION ; HORMESIS ; TOXICITY
WOS Research AreaEnvironmental Sciences ; Toxicology
WOS IDWOS:000456226600085
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24641
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
Affiliation1.China Agr Univ, Yantai Res Inst, Ocean Coll, Yantai 264670, Peoples R China;
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China;
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China;
4.YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Liu, Feng,Lu, Zhen,Wu, Huifeng,et al. Dose-dependent effects induced by cadmium in polychaete Perinereis aibuhitensis[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,169:714-721.
APA Liu, Feng,Lu, Zhen,Wu, Huifeng,&Ji, Chenglong.(2019).Dose-dependent effects induced by cadmium in polychaete Perinereis aibuhitensis.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,169,714-721.
MLA Liu, Feng,et al."Dose-dependent effects induced by cadmium in polychaete Perinereis aibuhitensis".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 169(2019):714-721.
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