CO2-induced ocean acidification impairs the immune function of the Pacific oyster against Vibrio splendidus challenge: An integrated study from a cellular and proteomic perspective
Cao, Ruiwen1,3; Wang, Qing1; Yang, Dinglong1; Liu, Yongliang1; Ran, Wen1,3; Qu, Yi1,3; Wu, Huifeng2; Cong, Ming2; Li, Fei2; Ji, Chenglong2; Zhao, Jianmin1; Zhao, Jianmin(Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Shandong, Peoples R China)
2018-06-01
发表期刊SCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
卷号625页码:1574-1583
产权排序第1完成单位 ; 第2完成单位
摘要Ocean acidification (OA) and pathogenic diseases pose a considerable threat to key species of marine ecosystem. However, few studies have investigated the combined impact of reduced seawater pH and pathogen challenge on the immune responses of marine invertebrates. In this study, Pacific oysters, Crassostrea gigas, were exposed to OA (-2000 ppm) for 28 days and then challenged with Vibrio splendidus for another 72 h. Hemocytc parameters showed that V. splendidus infection exacerbated the impaired oyster immune responses under OA exposure. An iTRAQ-based quantitative proteomic analysis revealed that C. gigas responded differently to OA stress and V. splendidus challenge, alone or in combination. Generally, OA appears to act via a generalized stress response by causing oxidative stress, which could lead to cellular i [limy and cause disruption to the cytoskeleton, protein turnover, immune responses and energy metabolism. V. splendidus challenge in oysters could suppress the immune system directly and lead to a disturbed cytoskeleton structure, increased protein turnover and energy metabolism suppression, without causing oxidative stress. The combined OA- and V. splendidus-treated oysters ultimately presented a similar, but stronger proteomic response pattern compared with OA treatment alone. Overall, the impaired oyster immune functions caused by OA exposure may have increased the risk of V. splendidus infection. These results have important implications for the impact of OA on disease outbreaks in marine invertebrates, which would have significant economic and ecological repercussions. kV, (C) 2018 Elsevier B.V. All rights reserved.
关键词Ocean Acidification Crassostrea Gigas Vibrio Splendidus Immune Responses Proteome Response
DOI10.1016/j.scitotenv.2018.01.056
项目资助者Chinese Academy of Sciences(XDA11020305, KZZDEW-14) ; National Natural Science Foundation of China(31172388) ; Informatization Engineering of Scientific Research(XXH13506-305) ; Youth Innovation Promotion Association, CAS(2016196)
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收录类别SCI
关键词[WOS]CRASSOSTREA-GIGAS ; OXIDATIVE STRESS ; RUDITAPES-PHILIPPINARUM ; ACTIN POLYMERIZATION ; BIVALVE MOLLUSKS ; INNATE IMMUNITY ; PROTEIN ; TEMPERATURE ; RESPONSES ; MARINE
文章类型Article
语种英语
WOS研究方向Environmental Sciences & Ecology
WOS记录号WOS:000426356600158
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文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/23572
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Zhao, Jianmin; Zhao, Jianmin(Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Shandong, Peoples R China)
作者单位1.Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Shandong, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Cao, Ruiwen,Wang, Qing,Yang, Dinglong,et al. CO2-induced ocean acidification impairs the immune function of the Pacific oyster against Vibrio splendidus challenge: An integrated study from a cellular and proteomic perspective[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,625:1574-1583.
APA Cao, Ruiwen.,Wang, Qing.,Yang, Dinglong.,Liu, Yongliang.,Ran, Wen.,...&Zhao, Jianmin.(2018).CO2-induced ocean acidification impairs the immune function of the Pacific oyster against Vibrio splendidus challenge: An integrated study from a cellular and proteomic perspective.SCIENCE OF THE TOTAL ENVIRONMENT,625,1574-1583.
MLA Cao, Ruiwen,et al."CO2-induced ocean acidification impairs the immune function of the Pacific oyster against Vibrio splendidus challenge: An integrated study from a cellular and proteomic perspective".SCIENCE OF THE TOTAL ENVIRONMENT 625(2018):1574-1583.
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