Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum

doi:10.1016/j.fsi.2015.03.024

	Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum
	Ji, CL; Wu, HF; Zhou, M; Zhao, JM; Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
发表期刊	FISH & SHELLFISH IMMUNOLOGY
ISSN	1050-4648
	2015-06
卷号	44 期号:2 页码:430-435
关键词	Ruditapes Philippinarum Cadmium Biological Effects Metabolomics
DOI	10.1016/j.fsi.2015.03.024
产权排序	[Ji, Chenglong; Wu, Huifeng; Zhao, Jianmin] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China; [Zhou, Mo] NE Normal Univ, Environm Coll, Changchun 130024, Peoples R China
作者部门	中科院海岸带环境过程与生态修复重点实验室
英文摘要	Cadmium (Cd) is a known heavy metal pollutant in the Bohai Sea. Manila clam Ruditapes philippinarum is an important fishery species along the Bohai coast. In this study, the biological effects induced by two concentrations (20 and 200 mu g/L) of Cd were characterized using multiple biochemical indices in the digestive glands of clam R. philippinarum. The total hemocyte counts, reactive oxygen species productions and antioxidant enzyme activities exhibited that Cd induced dose-dependent immune and oxidative stresses in clam digestive glands. Metabolic responses indicated that both Cd exposures caused immune stress marked by the elevated branched chain amino acids (valine, leucine and isoleucine), together with the disturbance in energy metabolism. The differential metabolic biomarkers related to osmotic stress, including homarine, betaine, tyrosine and phenylalanine, suggested the differential responsive mechanisms in clam digestive glands induced by Cd exposures. In addition, both Cd treatments enhanced the anaerobiosis metabolism in clam digestive glands via differential metabolic pathways. (c) 2015 Elsevier Ltd. All rights reserved.; Cadmium (Cd) is a known heavy metal pollutant in the Bohai Sea. Manila clam Ruditapes philippinarum is an important fishery species along the Bohai coast. In this study, the biological effects induced by two concentrations (20 and 200 mu g/L) of Cd were characterized using multiple biochemical indices in the digestive glands of clam R. philippinarum. The total hemocyte counts, reactive oxygen species productions and antioxidant enzyme activities exhibited that Cd induced dose-dependent immune and oxidative stresses in clam digestive glands. Metabolic responses indicated that both Cd exposures caused immune stress marked by the elevated branched chain amino acids (valine, leucine and isoleucine), together with the disturbance in energy metabolism. The differential metabolic biomarkers related to osmotic stress, including homarine, betaine, tyrosine and phenylalanine, suggested the differential responsive mechanisms in clam digestive glands induced by Cd exposures. In addition, both Cd treatments enhanced the anaerobiosis metabolism in clam digestive glands via differential metabolic pathways. (c) 2015 Elsevier Ltd. All rights reserved.
文章类型	期刊论文
资助机构	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
收录类别	SCI
语种	英语
关键词[WOS]	MUSSEL MYTILUS-GALLOPROVINCIALIS ; NMR-BASED METABOLOMICS ; VENERUPIS-PHILIPPINARUM ; BIVALVE MOLLUSKS ; RESPONSES ; COPPER ; GILLS ; CHALLENGE ; PROFILES ; MERCURY
研究领域[WOS]	National Key Basic Research Program of China [2015CB453303] ; Natural Science Foundation of Shandong Province [JQ201310]
WOS记录号	WOS:000354583800005
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/8618
专题	中国科学院海岸带环境过程与生态修复重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
推荐引用方式 GB/T 7714	Ji, CL,Wu, HF,Zhou, M,et al. Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum[J]. FISH & SHELLFISH IMMUNOLOGY,2015,44(2):430-435.
APA	Ji, CL,Wu, HF,Zhou, M,Zhao, JM,&Wu, HF .(2015).Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum.FISH & SHELLFISH IMMUNOLOGY,44(2),430-435.
MLA	Ji, CL,et al."Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum".FISH & SHELLFISH IMMUNOLOGY 44.2(2015):430-435.

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