Recent advances in molecular imprinting technology: current status, challenges and highlighted applications
Chen, Lingxin1; Xu, Shoufang1,2; Li, Jinhua1
2011
Source PublicationCHEMICAL SOCIETY REVIEWS
ISSN0306-0012
Volume40Issue:5Pages:2922-2942
Contribution Rank[Chen, Lingxin; Xu, Shoufang; Li, Jinhua] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Xu, Shoufang] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
AbstractMolecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).; Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).
Corresponding AuthorChen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China.lxchen@yic.ac.cn
KeywordSolid-phase Extraction Performance Liquid-chromatography Restricted-access Materials Functionalized Silica-gel Beta-cyclodextrin Polymer Precipitation Polymerization Water Samples Ionic Liquid Selective Extraction Protein Recognition
Department环境化学实验室 
Subject AreaChemistry, Multidisciplinary
Funding OrganizationChinese Academy of Sciences (IOCAS) [072715]; CAS/SAFEA
Indexed BySCI
WOS KeywordSOLID-PHASE EXTRACTION ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; RESTRICTED-ACCESS MATERIALS ; FUNCTIONALIZED SILICA-GEL ; BETA-CYCLODEXTRIN POLYMER ; PRECIPITATION POLYMERIZATION ; WATER SAMPLES ; IONIC LIQUID ; SELECTIVE EXTRACTION ; PROTEIN RECOGNITION
SubtypeReview
Language英语
WOS Research AreaChemistry
WOS IDWOS:000289630700046
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/4853
Collection中科院海岸带环境过程与生态修复重点实验室_环境化学实验室
中科院海岸带环境过程与生态修复重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lingxin,Xu, Shoufang,Li, Jinhua. Recent advances in molecular imprinting technology: current status, challenges and highlighted applications[J]. CHEMICAL SOCIETY REVIEWS,2011,40(5):2922-2942.
APA Chen, Lingxin,Xu, Shoufang,&Li, Jinhua.(2011).Recent advances in molecular imprinting technology: current status, challenges and highlighted applications.CHEMICAL SOCIETY REVIEWS,40(5),2922-2942.
MLA Chen, Lingxin,et al."Recent advances in molecular imprinting technology: current status, challenges and highlighted applications".CHEMICAL SOCIETY REVIEWS 40.5(2011):2922-2942.
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