Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide
Zhang, Xia1,5,6; Yang, Yang1; Zhang, Li1,6; Liu, Shudi2; Song, Zhihua3; Zhang, Liangwei1; You, Jinmao4; Chen, Lingxin1
Source PublicationTALANTA
ISSN0039-9140
2024-02-01
Volume268Pages:8
KeywordNew recognition moiety H2Sn Probe design Fluorescent probe Living cells imaging
DOI10.1016/j.talanta.2023.125293
Corresponding AuthorZhang, Liangwei(liangweizhang@yic.ac.cn) ; You, Jinmao(jmyou6304@163.com) ; Chen, Lingxin(lxchen@yic.ac.cn)
AbstractHydrogen polysulfide (H2Sn, n > 1) is an important component of reactive sulfur species (RSS), which is an important substance for maintaining the redox balance in cells. However, limited recognition moieties are available for hydrogen polysulfide probe design. In this study, we have constructed a small library containing several organic molecules to explore a new specific recognition moiety for H2Sn fluorescent probe design. To validate the discovery, two fluorescent probes, 7 and BCC, were further developed based on coumarin and its derivative. The probes exhibited desirable specificity for H2Sn monitoring, which can be used for detecting H2Sn in solution and cells. The new specific recognition moiety for H2Sn fluorescent probe design discovered in this work has certain guiding significance for development of H2Sn probes exploring biological roles in the future.
Funding OrganizationNational Natural Science Foundation of China ; Major Innovation Fund of Shandong Province ; Program of Youth Innovation Promotion Association, CAS ; Taishan Scholar Project Special Funding
Indexed BySCI
Language英语
WOS KeywordLIVING CELLS ; SULFIDE ; LIPOPOLYSACCHARIDE ; PERSULFIDES
WOS Research AreaChemistry
WOS IDWOS:001104798600001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/33241
Collection中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Corresponding AuthorZhang, Liangwei; You, Jinmao; Chen, Lingxin
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China
3.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
4.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China
5.Binzhou Med Univ, Dept Biochem & Mol Biol, Yantai 264003, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xia,Yang, Yang,Zhang, Li,et al. Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide[J]. TALANTA,2024,268:8.
APA Zhang, Xia.,Yang, Yang.,Zhang, Li.,Liu, Shudi.,Song, Zhihua.,...&Chen, Lingxin.(2024).Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide.TALANTA,268,8.
MLA Zhang, Xia,et al."Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide".TALANTA 268(2024):8.
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