Responsive fluorescent probes for cellular microenvironment and redox small biomolecules

doi:10.1016/j.trac.2023.117377

	Responsive fluorescent probes for cellular microenvironment and redox small biomolecules
	Zhang, Li 1,3; Zhang, Liangwei1 ; Zhang, Xia 1,3,5; Zhao, Yang 1; Fang, Shujing 1; You, Jinmao 4; Chen, Lingxin1,2
发表期刊	TRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN	0165-9936
	2023-12-01
卷号	169 页码:23
关键词	Response fluorescent probes Microenvironment Redox small biomolecules Specific recognition sites Design strategy Biological applications
DOI	10.1016/j.trac.2023.117377
通讯作者	Zhang, Liangwei(liangweizhang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	The living system is critically depended on the inner microenvironment and redox small biomolecules to maintain the normal physiological processes. Consequently, tracing and monitoring the functional mechanism of the microenvironment and redox small biomolecules remain of extraordinary significance. Fluorescent probes have emerged for bearing the important tasks of biosensing and bioimaging with superior fluorescence signal and superb targeting specificity. In this review, we focus on the responsive fluorescent probes of microenvironment-related parameters of pH, viscosity and hypoxia, and redox small biomolecules of the reactive oxygen species, reactive nitrogen species, reactive sulfur specie, respectively. Each category is firstly devoted generally functions of the target molecule properties, and then discuss the design strategy according to the specific recognition groups, as well as biological applications. We hope our review will provide useful guidance in development advanced fluorescence probe for monitoring the microenvironments and redox small biomolecules to reveal their special biological processes.
资助机构	National Natural Science Foundation of China ; Program of Youth Innovation Promotion Association, CAS ; Taishan Scholar Project Special Funding ; major innovation fund of Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	LARGE STOKES SHIFT ; LIVING CELLS ; HYDROGEN-SULFIDE ; SUPEROXIDE ANION ; RATIONAL DESIGN ; REACTIVE OXYGEN ; RECENT PROGRESS ; ENDOPLASMIC-RETICULUM ; FLUOROGENIC PROBE ; MOLECULE PROBE
研究领域[WOS]	Chemistry
WOS记录号	WOS:001102342300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/33217
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Zhang, Liangwei; Chen, Lingxin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China 5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Li,Zhang, Liangwei,Zhang, Xia,et al. Responsive fluorescent probes for cellular microenvironment and redox small biomolecules[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2023,169:23.
APA	Zhang, Li.,Zhang, Liangwei.,Zhang, Xia.,Zhao, Yang.,Fang, Shujing.,...&Chen, Lingxin.(2023).Responsive fluorescent probes for cellular microenvironment and redox small biomolecules.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,169,23.
MLA	Zhang, Li,et al."Responsive fluorescent probes for cellular microenvironment and redox small biomolecules".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 169(2023):23.