Abnormality of mussel in the early developmental stages induced by graphene and triphenyl phosphate: In silico toxicogenomic data-mining, in vivo, and toxicity pathway-oriented approach
Wang, Xiaoqing1,2; Li, Fei1,3; Meng, Xiangjing1,2; Xia, Chunlei1,3; Ji, Chenglong1,3; Wu, Huifeng1,3
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
2023-10-01
Volume263Pages:11
KeywordPlastic additives Graphene-based nanomaterials Toxicogenomic data mining Combined hazards Developmental abnormality
DOI10.1016/j.aquatox.2023.106674
Corresponding AuthorLi, Fei(fli@yic.ac.cn)
AbstractIncreasing number of complex mixtures of organic pollutants in coastal area (especially for nanomaterials and micro/nanoplastics associated chemicals) threaten aquatic ecosystems and their joint hazards are complex and demanding tasks. Mussels are the most sensitive marine faunal groups in the world, and their early developmental stages (embryo and larvae) are particularly susceptible to environmental contaminants, which can distinguish the probable mechanisms of mixture-induced growth toxicity. In this study, the potential critical target and biological processes affected by graphene and triphenyl phosphate (TPP) were developed by mining public toxicogenomic data. And their combined toxic effects were verified by toxicological assay at early developmental stages in filter-feeding mussels (embryo and larvae). It showed that interactions among graphene/ TPP with 111 genes (ABCB1, TP53, SOD, CAT, HSP, etc.) affected phenotypes along conceptual framework linking these chemicals to developmental abnormality endpoints. The PPAR signaling pathway, monocarboxylic acid metabolic process, regulation of lipid metabolic process, response to oxidative stress, and gonad development were noted as the key molecular pathways that contributed to the developmental abnormality. Enriched phenotype analysis revealed biological processes (cell proliferation, cell apoptosis, inflammatory response, response to oxidative stress, and lipid metabolism) affected by the investigated mixture. Combined, our results supported that adverse effects induced by contaminants/ mixture could not only be mediated by single receptor signaling or be predicted by the simple additive effect of contaminants. The results offer a framework for better comprehending the developmental toxicity of environmental contaminants in mussels and other invertebrate species, which have considerable potential for hazard assessment of coastal mixture.
Funding OrganizationNational Natural Science Founda-tion of China (NSFC) -Shandong Joint Fund ; National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Youth Innovation Promotion Association CAS
Indexed BySCI
Language英语
WOS KeywordEARLY EMBRYO DEVELOPMENT ; FRESH-WATER MUSSEL ; MYTILUS-GALLOPROVINCIALIS ; MOLECULAR-MECHANISMS ; ZEBRAFISH EMBRYOS ; FLAME RETARDANTS ; LARVAL STAGES ; LIFE-STAGES ; NANOPARTICLES ; CADMIUM
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS IDWOS:001070117600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/32855
Collection中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
Corresponding AuthorLi, Fei
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, YICCAS,Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xiaoqing,Li, Fei,Meng, Xiangjing,et al. Abnormality of mussel in the early developmental stages induced by graphene and triphenyl phosphate: In silico toxicogenomic data-mining, in vivo, and toxicity pathway-oriented approach[J]. AQUATIC TOXICOLOGY,2023,263:11.
APA Wang, Xiaoqing,Li, Fei,Meng, Xiangjing,Xia, Chunlei,Ji, Chenglong,&Wu, Huifeng.(2023).Abnormality of mussel in the early developmental stages induced by graphene and triphenyl phosphate: In silico toxicogenomic data-mining, in vivo, and toxicity pathway-oriented approach.AQUATIC TOXICOLOGY,263,11.
MLA Wang, Xiaoqing,et al."Abnormality of mussel in the early developmental stages induced by graphene and triphenyl phosphate: In silico toxicogenomic data-mining, in vivo, and toxicity pathway-oriented approach".AQUATIC TOXICOLOGY 263(2023):11.
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