Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics

doi:10.1002/mnfr.202200638

	Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics
	Zeng, Hongliang 1,2,3; Chen, Peilin 1,2; Wang, Zhiyun 1,2; Hu, Xiaoke4 ; Zhang, Yi 1,2,3; Zheng, Baodong 1,2,3
发表期刊	MOLECULAR NUTRITION & FOOD RESEARCH
ISSN	1613-4125
	2023-01-26
页码	15
关键词	gut microbiota gut-liver axis hyperlipidemia lipomics Porphyra haitanensis polysaccharide transcriptomics
DOI	10.1002/mnfr.202200638
通讯作者	Zhang, Yi(zyifst@fafu.edu.cn) ; Zheng, Baodong(zbdfst@fafu.edu.cn)
英文摘要	ScopeHyperlipidemia is currently a global public health problem severely affecting people's physical and mental health, as well as their quality of life. Methods and resultsThe present study is aimed at revealing the mechanism of Porphyra haitanensis polysaccharide (PHP) in decreasing blood lipids by acting through gut-liver axis in Mesocricetus auratus fed a high-fat diet. PHP significantly prevented increases in serum total cholesterol, triglycerides and low-density lipoprotein cholesterol, and alleviated damage to liver cells induced by a high-fat diet M. auratus, in a dose-dependent manner. PHP promotes proliferation of Muribaculaceae and Faecalibaculum, thereby enhancing the production of butyric acid both in the colon and liver, particularly high-dose PHP (HPHP). Low-dose PHP (LPHP) promotes the expression of phosphatidylcholine metabolites and fatty acid transport genes, and inhibits the expression of genes involved in fat degradation (Abhd5), adipogenesis (Me1), fatty acid synthesis (Fasn and Pnpla3), and fatty acid chain elongation (Elovl6) in the liver. However, HPHP inhibits the expression of triglyceride metabolites and promotes the expression of fatty acid transporter (CD36), fatty acid oxidation (Acacb), and peroxisome proliferator-activated receptor gamma (PPARg) genes in the liver. ConclusionPHP regulates lipid metabolism through the gut microbiota, and the gut-liver axis plays an important role in its hypolipidemic effects.
资助机构	Program for Leading Talent in Fujian Provincial University
收录类别	SCI
语种	英语
关键词[WOS]	LIPOPROTEIN-LIPASE ; IN-VITRO ; SULFATED POLYSACCHARIDE ; HEPATIC STEATOSIS ; ADIPOSE-TISSUE ; PPAR-GAMMA ; MICROBIOTA ; OBESITY ; VIVO ; ANTIOXIDANT
研究领域[WOS]	Food Science & Technology
WOS记录号	WOS:000918971400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32084
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Zhang, Yi; Zheng, Baodong
作者单位	1.Minist Educ, Engn Res Ctr Fujian Taiwan Special Marine Food Pro, Fuzhou 350002, Fujian, Peoples R China 2.Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China 3.Fujian Agr & Forestry Univ, Fujian Prov Key Lab Qual Sci & Proc Technol Specia, Fuzhou 350002, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Hongliang,Chen, Peilin,Wang, Zhiyun,et al. Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2023:15.
APA	Zeng, Hongliang,Chen, Peilin,Wang, Zhiyun,Hu, Xiaoke,Zhang, Yi,&Zheng, Baodong.(2023).Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics.MOLECULAR NUTRITION & FOOD RESEARCH,15.
MLA	Zeng, Hongliang,et al."Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics".MOLECULAR NUTRITION & FOOD RESEARCH (2023):15.