Potential adverse outcome pathways with hazard identification of organophosphate esters

doi:10.1016/j.scitotenv.2022.158093

	Potential adverse outcome pathways with hazard identification of organophosphate esters
	Wang, Xiaoqing1,3 ; Li, Fei1,2,4 ; Teng, Yuefa 1,3; Ji, Chenglong1,2 ; Wu, Huifeng1,2
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
	2022-12-10
卷号	851 页码:13
关键词	Organophosphate esters (OPEs) Network-centric analysis Risk assessment Adverse outcome pathway Quantitative weight of evidence
DOI	10.1016/j.scitotenv.2022.158093
通讯作者	Li, Fei(fli@yic.ac.cn)
英文摘要	Data-driven analysis and pathway-based approaches contribute to reasonable arrangements of limited resources and laboratory tests for continuously emerging commercial chemicals, which provides opportunities to save time and effort for toxicity research. With the widespread usage of organophosphate esters (OPEs) on a global scale, the concentra-tions generally reached up to micromolar range in environmental media and even in organisms. However, potential adverse effects and toxicity pathways of OPEs have not been systematically assessed. Therefore, it is necessary to review the current situation, formulate the future research priorities, and characterize toxicity mechanisms via data -driven analysis. Results showed that the early toxicity studies focused on neurotoxicity, cytotoxicity, and metabolic disorders. Then the main focus shifted to the mechanisms of cardiotoxicity, endocrine disruption, hepatocytes, repro-ductive and developmental toxicity to vulnerable sub-populations, such as infants and embryos, affected by OPEs. In addition, several novel OPEs have been emerging, such as bis(2-ethylhexyl)-phenyl phosphate (HDEHP) and oxidation derivatives (OPAs=O) generated from organophosphite antioxidants (OPAs), leading to multiple potential ecological and human health risks (neurotoxicity, hepatotoxicity, developmental toxicity, etc.). Notably, in-depth statistical anal-ysis was promising in encapsulating toxicological information to develop adverse outcome pathways (AOPs) frame-works. Subsequently, network-centric analysis and quantitative weight-of-evidence (QWOE) approaches were utilized to construct and evaluate the putative AOPs frameworks of OPEs, showing the moderate confidences of the developed AOPs. In addition, frameworks demonstrated that several events, such as nuclear receptor activation, reac-tive oxygen species (ROS) production, oxidative stress, and DNA damage, were involved in multiple different adverse outcome (AO), and these AOs had certain degree of connectivity. This study brought new insights into facilitating the complement of AOP efficiently, as well as establishing toxicity pathways framework to inform risk assessment of emerging OPEs.
资助机构	National Natural Science Foundation of China ; Yantai Science and Technology Development Plan ; Youth Innovation Promotion Association CAS
收录类别	SCI
语种	英语
关键词[WOS]	TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE TDCPP ; REGULATORY DECISION-MAKING ; FLAME RETARDANTS OPFRS ; EARLY-LIFE STAGES ; TRIPHENYL PHOSPHATE ; DEVELOPMENTAL NEUROTOXICITY ; ENDOCRINE DISRUPTION ; FIREMASTER(R) 550 ; OXIDATIVE STRESS ; TROPHIC TRANSFER
研究领域[WOS]	Environmental Sciences & Ecology
WOS记录号	WOS:000877919900015
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31991
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Li, Fei
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCA, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiaoqing,Li, Fei,Teng, Yuefa,et al. Potential adverse outcome pathways with hazard identification of organophosphate esters[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,851:13.
APA	Wang, Xiaoqing,Li, Fei,Teng, Yuefa,Ji, Chenglong,&Wu, Huifeng.(2022).Potential adverse outcome pathways with hazard identification of organophosphate esters.SCIENCE OF THE TOTAL ENVIRONMENT,851,13.
MLA	Wang, Xiaoqing,et al."Potential adverse outcome pathways with hazard identification of organophosphate esters".SCIENCE OF THE TOTAL ENVIRONMENT 851(2022):13.