Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture

doi:10.1016/j.jhazmat.2021.128154

	Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture
	Lu, Jian1,2,4 ; Zhang, Yuxuan1,2 ; Wu, Jun 3; Wang, Jianhua1,2
发表期刊	JOURNAL OF HAZARDOUS MATERIALS
ISSN	0304-3894
	2022-04-05
卷号	427 页码:9
关键词	Antimicrobial peptide Antibiotics Antibiotic resistance genes Aquaculture
DOI	10.1016/j.jhazmat.2021.128154
通讯作者	Wu, Jun(wujunlisa@163.com)
英文摘要	Antibiotic resistance genes (ARGs) widely exist in diverse matrices to pose potential risks and attract global attention. This study performed tilapia-cultivation experiment to discuss the intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture by analyzing 29 target ARGs in water, residue, and fish muscle samples. The sul1 gene was the dominant ARG in most of samples while absolute abundances of total ARGs were in the range of 1.5 x 102-2.3 x 107 copies/mL in water samples and 2.1 x 108-3.9 x 109 copies/g in the residue and fish muscle samples. Compared with antibiotic treatment, the cecropin treatment could significantly reduce the absolute abundance of ARGs and intI1 in all samples. Proteobacteria were the dominant phylum for most of samples while Aeromonas/Cetobacterium served as the dominant genus for samples with antibiotic/cecropin treatment. Network analysis showed that cecropin treatment could significantly reduce occurrence of multi-drug resistant bacteria and the correlation between genera and ARGs. Results of partial least squares structural equation modeling which was used to discuss the influential factors of ARGs exhibited that antibiotics could increase ARGs, further proving that cecropin peptide could effectively reduce ARGs in aquaculture. This study will provide important information on controlling ARGs in aquaculture in terms of antimicrobial peptide application.
资助机构	National Natural Foundation of China ; Taishan Scholars Program of dong Province ; Science and Technology Network Initiative of the Chinese Academy of Sciences ; Two-Hundred Talents Plan of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	ANTIBIOTIC-RESISTANCE ; GENES
研究领域[WOS]	Engineering ; Environmental Sciences & Ecology
WOS记录号	WOS:000752478900003
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31475
专题	中国科学院海岸带环境过程与生态修复重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Wu, Jun
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 3.Harbin Engn Univ, Yantai Res Inst, Yantai 264006, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Lu, Jian,Zhang, Yuxuan,Wu, Jun,et al. Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,427:9.
APA	Lu, Jian,Zhang, Yuxuan,Wu, Jun,&Wang, Jianhua.(2022).Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture.JOURNAL OF HAZARDOUS MATERIALS,427,9.
MLA	Lu, Jian,et al."Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture".JOURNAL OF HAZARDOUS MATERIALS 427(2022):9.