The residues of sulfonamides (SAs) antibiotics cause great harm to organisms and environments. Appropriate sample pretreatment is usually imperative to couple with chromatography / mass spectrometry analysis for the sensitive determination of SAs, owing to their low level residues and multiple categories presence in complicated matrices. Molecularly imprinted polymers (MIPs) have the binding sites complementary to the template molecules in shape, size and functional groups. So, MIPs can selectively recognize and effectively enrich target analytes (template) as well as eliminate matrices interferences. Thereby they have been widely applied in the sample pretreatment of SAs antibiotics. In this review, recent advances in sample pretreatment applications of MIPs for determination of SAs residues are summarized, mainly including conventional packed solid-phase extraction (PSPE), dispersive solid-phase extraction (DSPE), magnetic solid-phase extraction (MSPE) and temperature sensitive solid-phase extraction (TSPE). Several challenge issues of MIPs are given, and some new imprinting technologies and strategies for preparation of MIPs towards SAs are highlighted, such as surface imprinting technology, nanoimprinting technology and molecularly imprinted membrane technology, as well as multi-template imprinting strategy and dummy imprinting strategy. Finally, an outlook on the preparation and pretreatment application of SAs-MIPs is proposed.

磺胺类(Sulfonamides,SAs)抗生素残留极大危害生物体和环境,其含量低、种类多、基质复杂,通常需要进 行样品前处理结合色谱/ 质谱分析以实现灵敏检测。 分子印迹聚合物(Molecularly imprinted polymers,MIPs)是具有与 模板分子在形状、大小及官能团完全匹配的特异性识别位点的高分子聚合物,能选择性识别和富集目标分析物(模板 分子)并消除干扰,已广泛用于 SAs 的样品前处理。 本文综述了 MIPs 在 SAs 残留检测中的样品前处理应用,主要包括 装柱固相萃取、分散固相萃取、磁固相萃取、温敏性固相萃取等,总结了 MIPs 制备中面临的挑战,重点介绍了制备 SAs -MIPs 的印迹新技术和新策略,如表面印迹技术、纳米印迹技术、分子印迹膜技术,多模板印迹策略、虚拟模板印迹策 略等。 最后,展望了 SAs-MIPs 的制备和前处理应用。