Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis
Wang, Shuang1; Ji, Chenglong1,2,3; Li, Fei1,3; Zhan, Junfei1,4; Sun, Tao1,4; Tang, Jianhui1,3; Wu, Huifeng1,2,3
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
2021-08-15
Volume416Pages:9
KeywordBrominated flame retardants Marine invertebrates Endocrine disruptor Steroids sulfonation
DOI10.1016/j.jhazmat.2021.126228
Corresponding AuthorJi, Chenglong(clji@yic.ac.cn) ; Wu, Huifeng(hfwu@yic.ac.cn)
AbstractTetrabromobisphenol A (TBBPA) pollution in marine environmental media poses great risks to marine organisms due to its potential endocrine-disrupting effects. However, limited attention of TBBPA's endocrine-disrupting effects has been paid on marine invertebrates. In this work, the reproductive endocrine-disrupting effects of TBBPA were evaluated by observing the gametes development, quantifying the gender-specific gene expression, and determining vertebrate sex hormones in mussels Mytilus galloprovincialis treated with TBBPA for 30 days. Additionally, transcriptomic profiling and enzymes activities were conducted to investigate the potential mechanisms of reproductive endocrine-disrupting effects. We found that promotion of gametogenesis and alterations of vertebrate sex hormones occurred in TBBPA-treated mussels of both sexes. Meanwhile, estrogen sulfotransferase (SULT1E1) and steroid sulfatase (STS) were up-regulated at transcript level as a result of TBBPA treatments, suggesting that TBBPA disrupted the steroidogenesis in mussels through promoting steroids sulfo-nation and hydrolysis of sulfate steroids. The induction of SULTs for TBBPA biotransformation might be responsible for the dysregulation of steroidogenesis and steroids metabolism. Overall, these findings provide a new insight into assessing impact of TBBPA as well as TBBPA biomonitoring in marine environment.
Funding OrganizationNational Natural Science Foundation of China ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS ; Yantai Science and Technology Development Plan
Indexed BySCI
Language英语
WOS KeywordGENDER-SPECIFIC RESPONSES ; SCALLOP CHLAMYS-FARRERI ; TESTOSTERONE CONCENTRATIONS ; BISPHENOL-A ; TBBPA ; ESTRADIOL-17-BETA ; SEX ; GAMETOGENESIS ; GLUCURONIDE ; SULFATASE
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS IDWOS:000664769200005
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/29459
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorJi, Chenglong; Wu, Huifeng
Affiliation1.Chinese Acad Sci, Shandong Key Lab Coastal Environm Processes, CAS Key Lab Coastal Environm Processes & Ecol Rem, Yantai Inst Coastal Zone Res,YICCAS, Yantai 264003, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 26071, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shuang,Ji, Chenglong,Li, Fei,et al. Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,416:9.
APA Wang, Shuang.,Ji, Chenglong.,Li, Fei.,Zhan, Junfei.,Sun, Tao.,...&Wu, Huifeng.(2021).Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis.JOURNAL OF HAZARDOUS MATERIALS,416,9.
MLA Wang, Shuang,et al."Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis".JOURNAL OF HAZARDOUS MATERIALS 416(2021):9.
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