| Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations | |
Sun, Tao1,4; Zhan, Junfei1,4; Li, Fei1,3 ; Ji, Chenglong1,2,3; Wu, Huifeng1,2,3
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| 发表期刊 | SCIENCE OF THE TOTAL ENVIRONMENT
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| ISSN | 0048-9697 |
| 2021-08-20 | |
| 卷号 | 783页码:9 |
| 关键词 | Microplastics Aquatic organisms Genotoxicity Meta-analysis Environmentally relevant concentrations |
| DOI | 10.1016/j.scitotenv.2021.147076 |
| 通讯作者 | Wu, Huifeng(hfwu@yic.ac.cn) |
| 英文摘要 | Microplastics (MPs) attract global concern due to their ubiquitous existence in aquatic environments. However, the genotoxic effect of MPs on aquatic organisms in the natural environment remains controversial. Therefore, this meta-analysis was conducted by recompiling 44 individual studies from 12 publications to determine whether MPs could induce genotoxicity in aquatic organisms at environmentally relevant concentrations (<= 1 mg/L, median = 0.5 mg/L). Multiple genotoxic endpoints were involved, including the percentage of DNA in tail (TDNA%), tail length (TL), olive tail moment (OTM), and the number of micronuclei (NM), and their increases represented the biologically adverse effects (i.e. genotoxicity). The results showed that all included endpoints tended to increase after exposure to MPs, among which TDNA%, TL and NM were significantly increased by 20%, 32% and 81% compared with the control group, respectively. The overall estimate of all endpoints in the MPs-treated groups was remarkably increased by 24%, with high statistical power and no obvious publication bias, suggesting the evident genotoxicity caused by MPs. In addition, the magnitudes of MPs-induced genotoxicity were independent of selected endpoint, MP composition, morphology, exposure concentration and duration, but closely correlated with particle size, living habitat and tested species. Overall, this work provided a reference for the health risk assessment of MPs in the natural environment, contributing to our understanding the action mode of MPs at environmentally relevant concentrations.& nbsp; (c) 2021 Elsevier B.V. All rights reserved. |
| 资助机构 | National Natural Science Foundation of China ; Young Taishan Scholars Program of Shandong Province |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | MARINE-ENVIRONMENT ; POLYSTYRENE MICROPLASTICS ; MYTILUS SPP. ; EXPOSURE ; NANOPLASTICS ; FRAGMENTATION ; CONTAMINANTS ; RESPONSES ; IMPACT ; LEAD |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| WOS记录号 | WOS:000656998400016 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/29386 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wu, Huifeng |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Tao,Zhan, Junfei,Li, Fei,et al. Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,783:9. |
| APA | Sun, Tao,Zhan, Junfei,Li, Fei,Ji, Chenglong,&Wu, Huifeng.(2021).Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations.SCIENCE OF THE TOTAL ENVIRONMENT,783,9. |
| MLA | Sun, Tao,et al."Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations".SCIENCE OF THE TOTAL ENVIRONMENT 783(2021):9. |
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