Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos | |
Ji, Yunxia1; Wang, Chuyu1; Wang, Yunqing1,2 ; Fu, Longwen1; Man, Mingsan1; Chen, Lingxin1,2,3
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| Source Publication | ENVIRONMENTAL SCIENCE-NANO
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| ISSN | 2051-8153 |
| 2020-08-01 | |
| Volume | 7Issue:8Pages:2313-2324 |
| DOI | 10.1039/d0en00464b |
| Corresponding Author | Wang, Yunqing(yqwang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) |
| Abstract | Nanoplastics (NPs) as pollutants in aquatic environments and as a public health issue due to their accumulation in food chains are of increasing concern. However, previous studies have employed mainly commercial, chemically synthesized polystyrene model particles. Commercial NPs made of polyethylene terephthalate (PET), which is widely used in drinking bottles and packaging, are rarely manufactured, and thus have not been frequently studied in the laboratory. This seriously limits our understanding of their real environmental and biological effects. Herein, we employ a simple method for producing PET NPs directly from plastic bottles, preserving the PET chemical properties, and mimicking the mechanical breakdown process of plastics in nature. Using developing zebrafish embryos as an animal model, we investigate the bioaccumulation andin vivotoxicity of the produced PET NPs, which have diameter sizes of 20, 60-80, and 800 nm and are capped by two dispersing agents,i.e., BSA and SDS. This study demonstrates the size-dependent distribution and the size- and concentration-dependent toxicity of PET NPs in terms of hatching rate, heart rate, and ROS generation. It also reveals that the PETBSANP treatment groups exhibited higher-level abnormalities in heart rate and more severe oxidative damage than the PETSDSNP treatment groups. Taken together, this work proposes a novel mechanical preparation protocol for PET NPs and provides evidence relating to the toxicity of environmentally relevant NPs towards aquatic organisms. |
| Funding Organization | National Natural Science Foundation of China ; Science and Technology Development Plan of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Technical Innovation Project of Instrument Function Development of the Chinese Academy of Sciences |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | CONFORMATIONAL-CHANGES ; SILICA NANOPARTICLES ; PROTEIN ADSORPTION ; DANIO-RERIO ; PARTICLES ; MICROPLASTICS ; TOXICITY ; INGESTION ; SILVER ; DAMAGE |
| WOS Research Area | Chemistry ; Environmental Sciences & Ecology ; Science & Technology - Other Topics |
| WOS ID | WOS:000558930600007 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/28562 |
| Collection | 中科院海岸带环境过程与生态修复重点实验室 中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 |
| Corresponding Author | Wang, Yunqing; Chen, Lingxin |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China |
| Recommended Citation GB/T 7714 | Ji, Yunxia,Wang, Chuyu,Wang, Yunqing,et al. Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos[J]. ENVIRONMENTAL SCIENCE-NANO,2020,7(8):2313-2324. |
| APA | Ji, Yunxia,Wang, Chuyu,Wang, Yunqing,Fu, Longwen,Man, Mingsan,&Chen, Lingxin.(2020).Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos.ENVIRONMENTAL SCIENCE-NANO,7(8),2313-2324. |
| MLA | Ji, Yunxia,et al."Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos".ENVIRONMENTAL SCIENCE-NANO 7.8(2020):2313-2324. |
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| Realistic polyethyle（4369KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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