Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos
Ji, Yunxia1; Wang, Chuyu1; Wang, Yunqing1,2; Fu, Longwen1; Man, Mingsan1; Chen, Lingxin1,2,3
Source PublicationENVIRONMENTAL SCIENCE-NANO
ISSN2051-8153
2020-08-01
Volume7Issue:8Pages:2313-2324
DOI10.1039/d0en00464b
Corresponding AuthorWang, Yunqing(yqwang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
AbstractNanoplastics (NPs) as pollutants in aquatic environments and as a public health issue due to their accumulation in food chains are of increasing concern. However, previous studies have employed mainly commercial, chemically synthesized polystyrene model particles. Commercial NPs made of polyethylene terephthalate (PET), which is widely used in drinking bottles and packaging, are rarely manufactured, and thus have not been frequently studied in the laboratory. This seriously limits our understanding of their real environmental and biological effects. Herein, we employ a simple method for producing PET NPs directly from plastic bottles, preserving the PET chemical properties, and mimicking the mechanical breakdown process of plastics in nature. Using developing zebrafish embryos as an animal model, we investigate the bioaccumulation andin vivotoxicity of the produced PET NPs, which have diameter sizes of 20, 60-80, and 800 nm and are capped by two dispersing agents,i.e., BSA and SDS. This study demonstrates the size-dependent distribution and the size- and concentration-dependent toxicity of PET NPs in terms of hatching rate, heart rate, and ROS generation. It also reveals that the PETBSANP treatment groups exhibited higher-level abnormalities in heart rate and more severe oxidative damage than the PETSDSNP treatment groups. Taken together, this work proposes a novel mechanical preparation protocol for PET NPs and provides evidence relating to the toxicity of environmentally relevant NPs towards aquatic organisms.
Funding OrganizationNational Natural Science Foundation of China ; Science and Technology Development Plan of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Technical Innovation Project of Instrument Function Development of the Chinese Academy of Sciences
Indexed BySCI
Language英语
WOS KeywordCONFORMATIONAL-CHANGES ; SILICA NANOPARTICLES ; PROTEIN ADSORPTION ; DANIO-RERIO ; PARTICLES ; MICROPLASTICS ; TOXICITY ; INGESTION ; SILVER ; DAMAGE
WOS Research AreaChemistry ; Environmental Sciences & Ecology ; Science & Technology - Other Topics
WOS IDWOS:000558930600007
Citation statistics
Cited Times:54[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/28562
Collection中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Corresponding AuthorWang, Yunqing; Chen, Lingxin
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
Recommended Citation
GB/T 7714
Ji, Yunxia,Wang, Chuyu,Wang, Yunqing,et al. Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos[J]. ENVIRONMENTAL SCIENCE-NANO,2020,7(8):2313-2324.
APA Ji, Yunxia,Wang, Chuyu,Wang, Yunqing,Fu, Longwen,Man, Mingsan,&Chen, Lingxin.(2020).Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos.ENVIRONMENTAL SCIENCE-NANO,7(8),2313-2324.
MLA Ji, Yunxia,et al."Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos".ENVIRONMENTAL SCIENCE-NANO 7.8(2020):2313-2324.
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