| Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice | |
Li, Lili1,2 ; Wang, Yuting1,2,3; Yuan, Jingyi1,2,4; Liu, Zhengyi1,2; Ye, Changqing3; Qin, Song1,2
| |
| 发表期刊 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| ISSN | 0175-7598 |
| 2020-10-19 | |
| 页码 | 15 |
| 关键词 | Undaria pinnatifida Hyperlipidemia Adiposity Gut microbiota Metabolome High-fat diet |
| DOI | 10.1007/s00253-020-10954-9 |
| 通讯作者 | Ye, Changqing(cqye@ntu.edu.cn) ; Qin, Song(sqin@yic.ac.cn) |
| 英文摘要 | Dietary fiber has beneficial effects on obesity-related diseases and gut microbiota, contributing a key role in the interaction between dietary metabolism and host metabolism. Our objective was to investigate the cause of the improvement in multiple types of physiological states with seaweedUndaria pinnatifidatreatment on high-fat diet-fed mice and to evaluate whether its consequent anti-adiposity and anti-hyperlipidemic effects are associated with gut microbiota and its metabolomics regulation.U. pinnatifidaadministration in our experiment was shown to significantly decrease high-fat diet-induced body weight gain, as well as epididymal and abdominal adiposity.U. pinnatifidaintake also significantly reduced liver weight and serum triacylglycerol accumulation. We also found that improving effects ofU. pinnatifidaon high-fat diet-induced metabolic dysfunctions were associated with significant increase in specific bacteria, such asBacteroides acidifaciensandBacteroides ovatus, as well as metabolites, including short-chain fatty acids and tricarboxylic acid cycle intermediates. Our result provides a cheap dietary strategy to host metabolism improvement and obesity management. |
| 资助机构 | Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Program of Yantai |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | INSULIN-RESISTANCE ; FIBER ; ACIDS ; SUPPLEMENTATION ; METABOLITES ; SEAWEED ; EXTRACT ; IMPACT ; CANCER ; MASS |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| WOS记录号 | WOS:000580713400002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/28447 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Ye, Changqing; Qin, Song |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 3.Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lili,Wang, Yuting,Yuan, Jingyi,et al. Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2020:15. |
| APA | Li, Lili,Wang, Yuting,Yuan, Jingyi,Liu, Zhengyi,Ye, Changqing,&Qin, Song.(2020).Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,15. |
| MLA | Li, Lili,et al."Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020):15. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Undaria pinnatifidai（2628KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论