| Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment | |
Li, Qing1,2 ; Mi, Yingqi1,3; Tan, Wenqiang1,2; Guo, Zhanyong1,2
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| Source Publication | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 2020-12-01 | |
| Volume | 164Pages:4279-4288 |
| Keyword | Chitosan Free radical-scavenging Chemical modification |
| DOI | 10.1016/j.ijbiomac.2020.08.250 |
| Corresponding Author | Guo, Zhanyong(zhanyongguo@hotmail.com) |
| Abstract | Chitosan is an abundant and renewable polysaccharide, and chemical modification can be used to enhance the biological properties of chitosan. In this study, monophenol and ortho-diphenol were introduced to chitosan through chemical modification to get chitosan derivatives owned high antioxidant activity. Their free radical-scavenging activity against three free radicals and reduction ability was tested. Based on the four antioxidant assay, the antioxidant ability of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. The IC50 of inhibition of DPPH, hydroxyl ((OH)-O-center dot), and superoxide (O2 center dot-) radical-scavenging was 41-172, 10-89, and 14-38 mu g/mL, respectively. Meanwhile, ortho-diphenol was more efficient group than monophenol on the improvement of antioxidant ability of chitosan derivatives. The possible free radical-scavenging mechanism, including the number of the hydroxyl groups and the presence ortho-dihydroxy substitution for the antioxidant ability were discussed. In vitro studies demonstrated that the constructed chitosan derivatives have good biocompatibility, and good antioxidant capacity to reduce oxidative stress. Functionalization of chitosan with phenolic group allows the possible applications on the therapy of oxidative-related diseases. (C) 2020 Elsevier B.V. All rights reserved. |
| Funding Organization | Key Technology Research and Development Program of Shandong ; Natural Science Foundation of Shandong ; National Key Research & Development Program of China |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | ANTIOXIDANT ACTIVITY ; INULIN DERIVATIVES ; OXIDATIVE STRESS ; FLAVONOIDS ; POLYPHENOLS ; MECHANISMS ; AGENTS ; DPPH ; DFT |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS ID | WOS:000588093700407 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/27514 |
| Collection | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| Corresponding Author | Guo, Zhanyong |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shandong, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Qing,Mi, Yingqi,Tan, Wenqiang,et al. Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,164:4279-4288. |
| APA | Li, Qing,Mi, Yingqi,Tan, Wenqiang,&Guo, Zhanyong.(2020).Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,164,4279-4288. |
| MLA | Li, Qing,et al."Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 164(2020):4279-4288. |
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| Highly efficient fre（1621KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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