| Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction | |
Tan, Wenqiang1,2 ; Zhang, Jingjing1,2; Mi, Yingqi1,2,3; Dong, Fang1,2; Li, Qing1,2; Guo, Zhanyong1,2,3
| |
| Source Publication | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| ISSN | 0141-8130 |
| 2020-12-15 | |
| Volume | 165Pages:1765-1772 |
| Keyword | Chitosan Azide-alkyne click reaction Triphenylphosphonium Antifungal activity |
| DOI | 10.1016/j.ijbiomac.2020.10.019 |
| Corresponding Author | Guo, Zhanyong(zhanyongguo@hotmail.com) |
| Abstract | As one of the most promising biopolymers for a variety of potential applications, chitosan has attractedmuch attention because of its unique biological, chemical, and physical properties. The functionalization of chitosan has been adopted to synthesize novel chitosan derivatives with improved water-solubility and excellent biological activities. In this paper, chitosanwas functionalized with a triphenylphosphoniumgroup by means of the copper (I) catalyzed azide-alkyne "click" reaction and has been investigated as potential polymer for agricultural antifungal biomaterial. The influence of chemical modification on the structural characteristics and water-solubility of chitosanwas investigated by FTIR spectroscopy, H-1 NMRspectroscopy, elemental analysis, and UV-vis spectrum. Furthermore, the antifungal property of target chitosan derivative against four plant threatening fungal pathogens was evaluated and in vitro investigation demonstrated that triphenylphosphoniumsalt incorporated chitosan backbone had excellent antifungal property compared with chitosan and intermediate chitosan derivative. Notably, target chitosan derivative displayed relatively strongest antifungal effect with over 80% inhibitory index against Botrytis cinerea at 1.0 mg/mL. The results of a detailed antifungal study indicated that cationic chitosan derivative bearing 1,2,3-triazole and triphenylphosphonium moieties provided a promising platform for preparation of novel cationic antifungal biomaterials in the field of agriculture. (C) 2020 Elsevier B.V. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | ANTIMICROBIAL ACTIVITY ; QUATERNARY AMMONIUM ; PHOSPHONIUM ; ANTIOXIDANT ; CHEMISTRY |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| Funding Project | Youth Innovation Promotion Association CAS[2020219] ; Natural Science Foundation of Shandong Province of China[ZR2019BD064] ; National Key Research and Development Program of China[2019YFD0900705] ; Natural Science Foundation of Shandong Province Science and Technology Development Plan[2019GHY112010] |
| WOS ID | WOS:000600773500016 |
| Funding Organization | Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China ; National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/26156 |
| Collection | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| Corresponding Author | Guo, Zhanyong |
| Affiliation | 1.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,et al. Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,165:1765-1772. |
| APA | Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,Dong, Fang,Li, Qing,&Guo, Zhanyong.(2020).Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,165,1765-1772. |
| MLA | Tan, Wenqiang,et al."Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 165(2020):1765-1772. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment