Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction
Tan, Wenqiang1,2; Zhang, Jingjing1,2; Mi, Yingqi1,2,3; Dong, Fang1,2; Li, Qing1,2; Guo, Zhanyong1,2,3
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
2020-12-15
Volume165Pages:1765-1772
KeywordChitosan Azide-alkyne click reaction Triphenylphosphonium Antifungal activity
DOI10.1016/j.ijbiomac.2020.10.019
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
AbstractAs one of the most promising biopolymers for a variety of potential applications, chitosan has attractedmuch attention because of its unique biological, chemical, and physical properties. The functionalization of chitosan has been adopted to synthesize novel chitosan derivatives with improved water-solubility and excellent biological activities. In this paper, chitosanwas functionalized with a triphenylphosphoniumgroup by means of the copper (I) catalyzed azide-alkyne "click" reaction and has been investigated as potential polymer for agricultural antifungal biomaterial. The influence of chemical modification on the structural characteristics and water-solubility of chitosanwas investigated by FTIR spectroscopy, H-1 NMRspectroscopy, elemental analysis, and UV-vis spectrum. Furthermore, the antifungal property of target chitosan derivative against four plant threatening fungal pathogens was evaluated and in vitro investigation demonstrated that triphenylphosphoniumsalt incorporated chitosan backbone had excellent antifungal property compared with chitosan and intermediate chitosan derivative. Notably, target chitosan derivative displayed relatively strongest antifungal effect with over 80% inhibitory index against Botrytis cinerea at 1.0 mg/mL. The results of a detailed antifungal study indicated that cationic chitosan derivative bearing 1,2,3-triazole and triphenylphosphonium moieties provided a promising platform for preparation of novel cationic antifungal biomaterials in the field of agriculture. (C) 2020 Elsevier B.V. All rights reserved.
Indexed BySCI
Language英语
WOS KeywordANTIMICROBIAL ACTIVITY ; QUATERNARY AMMONIUM ; PHOSPHONIUM ; ANTIOXIDANT ; CHEMISTRY
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
Funding ProjectYouth Innovation Promotion Association CAS[2020219] ; Natural Science Foundation of Shandong Province of China[ZR2019BD064] ; National Key Research and Development Program of China[2019YFD0900705] ; Natural Science Foundation of Shandong Province Science and Technology Development Plan[2019GHY112010]
WOS IDWOS:000600773500016
Funding OrganizationYouth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China ; National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/26156
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,et al. Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,165:1765-1772.
APA Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,Dong, Fang,Li, Qing,&Guo, Zhanyong.(2020).Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,165,1765-1772.
MLA Tan, Wenqiang,et al."Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 165(2020):1765-1772.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tan, Wenqiang]'s Articles
[Zhang, Jingjing]'s Articles
[Mi, Yingqi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tan, Wenqiang]'s Articles
[Zhang, Jingjing]'s Articles
[Mi, Yingqi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tan, Wenqiang]'s Articles
[Zhang, Jingjing]'s Articles
[Mi, Yingqi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.