| A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment | |
Wang, Yue; Wang, Xiaoyan; Zhang, Li; Huang, Yan; Bi, Liyan; Lv, Changjun; Chen, Lingxin
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| 发表期刊 | JOURNAL OF MATERIALS CHEMISTRY B
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| ISSN | 2050-750X |
| 2020-02-07 | |
| 卷号 | 8期号:5页码:1017-1025 |
| 关键词 | CISPLATIN-INDUCED NEPHROTOXICITY REACTIVE OXYGEN VITAMIN-C CELL-PROLIFERATION LIPID-PEROXIDATION OXIDATIVE STRESS CURCUMIN MECHANISMS MITOCHONDRIA INHIBITION |
| 研究领域 | Materials Science, Biomaterials |
| DOI | 10.1039/c9tb02453k |
| 产权排序 | [Wang, Yue; Wang, Xiaoyan; Zhang, Li; Huang, Yan; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Wang, Yue; Zhang, Li] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wang, Xiaoyan; Huang, Yan; Bi, Liyan; Lv, Changjun; Chen, Lingxin] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China; [Chen, Lingxin] Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China; [Chen, Lingxin] Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China |
| 通讯作者 | Chen, Lingxin(lxchen@yic.ac.cn) |
| 作者部门 | 海岸带环境工程技术研究与发展中心 |
| 英文摘要 | Tumor resistance and drug-induced nephrotoxicity pose great challenges to the clinical treatment of tumors, and they also limit the clinical application of oncology drugs. Finding an effective adjuvant, which can sensitize tumor treatment, is an effective method for tumor treatment. Here, we developed a ratiometric fluorescent probe, TP-Tfs, for superoxide anion (O-2 & x2d9;(-)) detection in living cells and in vivo during the process of tumor treatment for the first time. TP-Tfs with simple synthesis steps and high yields can detect O-2 & x2d9;(-) sensitively and selectively, and the detection limit was determined to be 37 nM. Using TP-Tfs, we found that cis-diaminodichloroplatinum(ii) (DDP) was effective in treating tumors by inducing O-2 & x2d9;(-) burst. Curcumin (cum) can sensitize tumor treatment effectively by inducing more severe O-2 & x2d9;(-) burst. These results indicated that the probe TP-Tfs was a promising candidate for drug screening and tumor treatment evaluation. |
| 文章类型 | Article |
| 资助机构 | National Nature Science Foundation of ChinaNational Natural Science Foundation of China [21976209, 21575159, 21778026] ; Taishan Scholar Project Special Funding [ts20190962] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | CISPLATIN-INDUCED NEPHROTOXICITY ; REACTIVE OXYGEN ; VITAMIN-C ; CELL-PROLIFERATION ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; CURCUMIN ; MECHANISMS ; MITOCHONDRIA ; INHIBITION |
| 研究领域[WOS] | Materials Science |
| WOS记录号 | WOS:000528811300014 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/25089 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China; 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China; 5.Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yue,Wang, Xiaoyan,Zhang, Li,et al. A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(5):1017-1025. |
| APA | Wang, Yue.,Wang, Xiaoyan.,Zhang, Li.,Huang, Yan.,Bi, Liyan.,...&Chen, Lingxin.(2020).A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment.JOURNAL OF MATERIALS CHEMISTRY B,8(5),1017-1025. |
| MLA | Wang, Yue,et al."A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment".JOURNAL OF MATERIALS CHEMISTRY B 8.5(2020):1017-1025. |
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| A ratiometric fluore（5433KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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