| Self-assembly of nanoparticles by human serum albumin and photosensitizer for targeted near-infrared emission fluorescence imaging and effective phototherapy of cancer | |
Huang, Y; He, N; Wang, YQ ; Shen, DZ; Kang, Q; Zhao, RF; Chen, LX
| |
| 发表期刊 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| ISSN | 2050-750X |
| 2019-02-21 | |
| 卷号 | 7期号:7页码:1149-1159 |
| 关键词 | LUMINESCENT GOLD NANOPARTICLES INDOCYANINE GREEN PHOTODYNAMIC THERAPY RENAL CLEARANCE IN-VITRO ONE-POT NANOMATERIALS DECOMPOSITION NANOMEDICINE THERANOSTICS |
| 研究领域 | Materials Science, Biomaterials |
| DOI | 10.1039/c8tb03054e |
| 产权排序 | [Huang, Yan; Shen, Dazhong; Kang, Qi] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Minist Educ, Jinan 250014, Shandong, Peoples R China; [Huang, Yan; He, Na; Wang, Yunqing; Zhao, Rongfang; Chen, Lingxin] Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Peoples R China |
| 作者部门 | 海岸带环境工程技术研究与发展中心 |
| 英文摘要 | Photodynamic therapy (PDT) and photothermal therapy (PTT) are effective cancer treatments, and photosensitizers Way the most important role in the treatment. However, photosensitizers are insufficient for in vivo tumor treatment. Herein, we develop a small molecule fiuorophore Cy-HPT as a novel photosensitizer, which possesses the advantages of near-infrared (NIR) emission, high photothermal conversion efficiency and high singlet oxygen generation efficiency. Moreover, a nanoplatform of HSA@ Cy-HPT was synthesized by self-assembly of Cy-HPT and human serum albumin (HSA) in aqueous solution. Compared to Cy-HPT, HSA@Cy-HPT possesses more stable spectral properties, enhances the effect of PDT/PTT, and exhibits more satisfactory in vivo metabolism. HSA@Cy-HPT demonstrates outstanding tumor targeting in subcutaneous tumor xenograft models owing to its enhanced permeability and retention in tumor tissue. Furthermore, HSA@Cy-HPT was successfully utilized in tumor xenograft models and tumor tissue growth was clearly inhibited without any regrowth, extending survival rate of the models. Also, no distinct damage of the normal tissue of tumor xenograft models was observed using hematoxylin & eosin staining. This study presents a promising therapeutic agent for the synergetic PDT and PTT cancer treatment. |
| 文章类型 | Article |
| 资助机构 | National Nature Science Foundation of ChinaNational Natural Science Foundation of China [21575159, 81573393, 21575080] ; program of Youth Innovation Promotion Association, CAS [2017256] ; Instrument Developing Project of the Chinese Academy of Sciences [YZ201662] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | LUMINESCENT GOLD NANOPARTICLES ; INDOCYANINE GREEN ; PHOTODYNAMIC THERAPY ; RENAL CLEARANCE ; IN-VITRO ; ONE-POT ; NANOMATERIALS ; DECOMPOSITION ; NANOMEDICINE ; THERANOSTICS |
| 研究领域[WOS] | Materials Science, Biomaterials |
| WOS记录号 | WOS:000458659200012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24997 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Minist Educ, Jinan 250014, Shandong, Peoples R China; 2.Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 3.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Y,He, N,Wang, YQ,et al. Self-assembly of nanoparticles by human serum albumin and photosensitizer for targeted near-infrared emission fluorescence imaging and effective phototherapy of cancer[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(7):1149-1159. |
| APA | Huang, Y.,He, N.,Wang, YQ.,Shen, DZ.,Kang, Q.,...&Chen, LX.(2019).Self-assembly of nanoparticles by human serum albumin and photosensitizer for targeted near-infrared emission fluorescence imaging and effective phototherapy of cancer.JOURNAL OF MATERIALS CHEMISTRY B,7(7),1149-1159. |
| MLA | Huang, Y,et al."Self-assembly of nanoparticles by human serum albumin and photosensitizer for targeted near-infrared emission fluorescence imaging and effective phototherapy of cancer".JOURNAL OF MATERIALS CHEMISTRY B 7.7(2019):1149-1159. |
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