| Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models | |
He, N; Bai, S; Huang, Y; Xing, YL; Chen, LX ; Yu, FB; Lv, CJ
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| 发表期刊 | ANALYTICAL CHEMISTRY
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| ISSN | 0003-2700 |
| 2019-04-16 | |
| 卷号 | 91期号:8页码:5424-5432 |
| 关键词 | DESIGN STRATEGIES OXIDATIVE STRESS MOLECULAR DESIGN SUBSTRATE AGGREGATION INJURY SITES A1-1 |
| 研究领域 | Chemistry, Analytical |
| DOI | 10.1021/acs.analchem.9b00713 |
| 产权排序 | [He, Na; Bai, Song; Lv, Changjun] Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China; [Huang, Yan; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Xing, Yanlong; Yu, Fabiao] Hainan Med Univ, Coll Emergency & Trauma, Key Lab Hainan Trauma & Disaster Rescue, Inst Funct Mat & Mol Imaging,Coll Clin med, Haikou 571199, Hainan, Peoples R China; [He, Na; Bai, Song; Lv, Changjun] Binzhou Med Univ, Inst Mol Med, Med Res Ctr, Yantai 264003, Peoples R China |
| 通讯作者 | Chen, Lingxin(lxchen@yic.ac.cn) ; Yu, Fabiao(fbyu@yic.ac.cn) ; Lv, Changjun(lucky_lcj@sina.com) |
| 作者部门 | 海岸带环境工程技术研究与发展中心 |
| 英文摘要 | Idiopathic pulmonary fibrosis (IPF) is a lung-limited and progressive fibrotic disease. The early diagnosis and therapies of IPF are still full of clinical challenges. Glutathione S-transferase (GSTs) plays significant roles in promoting the formation of pulmonary fibrosis. Herein, we report a fluorescent probe (Cy-GST) for the detection of GSTs concentration fluctuations in cells and in mice models. The probe can selectively and sensitively respond to GSTs with an "off-on" type fluorescence switch. Our results demonstrated that the level of intracellular GSTs increase in the pulmonary fibrosis cells and mice models. And the IPF patients hold high levels of GSTs concentrations. Thus, GSTs are likely to play important roles in pulmonary fibrosis. The inhibitor of GSTs TLK117 can reduce the severity of pulmonary fibrosis. The synergistic treatment of TLK117 and pirfenidone have better therapeutic effects than only using pirfenidone in pulmonary fibrosis mice models. The level of GSTs in IPF may be a new potential marker for IPF diagnosis. And the inhibition of GSTs may be a new therapeutic strategy for IPF treatment. |
| 文章类型 | Article |
| 资助机构 | National Nature Science Foundation of ChinaNational Natural Science Foundation of China [21775162, 21864011, 81670064, 81870001] ; Talent Program of Hainan Medical University [XRC180006, XRC180007] ; Medical Science and Technology Development Project of Shandong Province [2017WS800] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | DESIGN STRATEGIES ; OXIDATIVE STRESS ; MOLECULAR DESIGN ; SUBSTRATE ; AGGREGATION ; INJURY ; SITES ; A1-1 |
| 研究领域[WOS] | Chemistry, Analytical |
| WOS记录号 | WOS:000465189600066 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24957 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 3.Hainan Med Univ, Coll Emergency & Trauma, Key Lab Hainan Trauma & Disaster Rescue, Inst Funct Mat & Mol Imaging,Coll Clin med, Haikou 571199, Hainan, Peoples R China; 4.Binzhou Med Univ, Inst Mol Med, Med Res Ctr, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, N,Bai, S,Huang, Y,et al. Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models[J]. ANALYTICAL CHEMISTRY,2019,91(8):5424-5432. |
| APA | He, N.,Bai, S.,Huang, Y.,Xing, YL.,Chen, LX.,...&Lv, CJ.(2019).Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models.ANALYTICAL CHEMISTRY,91(8),5424-5432. |
| MLA | He, N,et al."Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models".ANALYTICAL CHEMISTRY 91.8(2019):5424-5432. |
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