Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis
Meng, XJ; Li, F; Wang, XQ; Liu, JL; Ji, CL; Wu, HF
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
2019-10-15
Volume378Pages:UNSP 120778
KeywordJoint effects Graphene Triphenyl phosphate (TPP) Toxicity Mussel
MOST Discipline CatalogueEngineering, Environmental ; Environmental Sciences
DOI10.1016/j.jhazmat.2019.120778
Contribution Rank[Meng, Xiangjing; Li, Fei; Wang, Xiaoqing; Liu, Jialin; Ji, Chenglong; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China; [Ji, Chenglong; Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China; [Meng, Xiangjing; Wang, Xiaoqing] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Department海岸带环境过程实验室
AbstractOwing to its unique surface properties, graphene can absorb environmental pollutants, thereby affecting their environmental behavior. Triphenyl phosphate (TPP) is a highly produced flame retardant. However, the toxicities of graphene and its combinations with contaminants remain largely unexplored. In this work, we investigated the toxicological effects of graphene and TPP to mussel Mytilus galloprovincialis. Results indicated that graphene could damage the digestive gland tissues, but no significant changes were found in the graphene + TPP co-exposure group. There was a significant decrease in the content of GSH and the activities of GST and CAT in the co-exposure group compared to that in graphene-exposed group. It seemed that the adsorption of TPP on graphene could inhibit the surface activity of graphene and thus reduced its tissue damage and oxidative stress in mussels. Expression levels of stress response (MyD88a), cytoskeleton (MHC1, PMyo and TMyo) and reproductive (CP450 and HSD) genes were up-regulated in the graphene-exposed group, but significantly down-regulated after combined exposure of graphene and TPP. Furthermore, PPI analysis proved that the interactions of HSP90AA1 with UNC45B and FKBP4/5/6/L contributed to the toxicity caused by the combined exposure. Because of the potential toxicity of graphene and TPP, government administrators should consider its risks prior to the widespread environmental exposure.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordORGANOPHOSPHATE FLAME RETARDANTS ; MESSENGER-RNA EXPRESSION ; DEVELOPMENTAL TOXICITY ; OXIDATIVE STRESS ; OXIDE ; MECHANISMS ; NETWORK ; PLASTICIZERS ; CYTOTOXICITY ; ECOTOXICITY
WOS Research AreaEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000489188300067
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China [41530642, 21677173] ; Youth Innovation Promotion Association CAS [2017255, 2015169]
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24833
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China;
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Meng, XJ,Li, F,Wang, XQ,et al. Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis[J]. JOURNAL OF HAZARDOUS MATERIALS,2019,378:UNSP 120778.
APA Meng, XJ,Li, F,Wang, XQ,Liu, JL,Ji, CL,&Wu, HF.(2019).Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis.JOURNAL OF HAZARDOUS MATERIALS,378,UNSP 120778.
MLA Meng, XJ,et al."Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis".JOURNAL OF HAZARDOUS MATERIALS 378(2019):UNSP 120778.
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