| Synthesis, Characterization, and the Antioxidant Activity of Carboxymethyl Chitosan Derivatives Containing Thiourea Salts | |
Sun, XQ; Zhang, JJ; Chen, Y; Mi, YQ; Tan, WQ ; Li, Q; Dong, F; Guo, ZY
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| 发表期刊 | POLYMERS
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| 2019-11 | |
| 卷号 | 11期号:11页码:1810 |
| 关键词 | antioxidant ability characterization chitosan derivatives thiourea salts |
| 研究领域 | Polymer Science |
| DOI | 10.3390/polym11111810 |
| 产权排序 | [Sun, Xueqi; Zhang, Jingjing; Chen, Yuan; Mi, Yingqi; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Sun, Xueqi; Zhang, Jingjing; Chen, Yuan; Mi, Yingqi; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China; [Sun, Xueqi; Zhang, Jingjing; Chen, Yuan; Mi, Yingqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Dong, Fang(fdong@yic.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com) |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | A new class of chitosan derivatives possessing thiourea salts were synthesized to improve the solubility and the antioxidant activity of chitosan. Firstly, chitosan was modified to carboxymethyl chitosan, combining carboxymethyl chitosan with thiourea salts that have different structures to form new chitosan derivatives. The chitosan and chitosan derivatives were characterized by FT-IR, C-13 NMR, TGA, and elemental analyses. The new peaks of thiourea salts could be clearly observed at about 1240 cm(-1) in the IR spectra, and the peak of C=S was clearly observed at around 180 ppm in the C-13 NMR. IR spectra and C-13 NMR of the structural units of these polymers validated the chitosan derivatives possessing thiourea salts were successfully synthesized. Their antioxidant properties were tested, including DPPH-radical scavenging ability, superoxide-radical scavenging ability, and hydroxyl-radical scavenging ability. Our results suggested the increase of thiourea salt groups in chitosan derivatives promotes the scavenging effect. The scavenging activity of 4TMCMCS, TMCMCS. 4,4DCMCS, and 4ACMCS against DPPH-radical and superoxide-radical were more than 90% at 1.6 mg/mL, respectively. In the cytotoxicity assay, no cytotoxicity was observed for the L929 cells with chitosan and its derivatives at all testing concentrations. These results demonstrated that the combination of chitosan and thiourea salt groups improved the antioxidant activity of chitosan, and the antioxidants or free radical scavengers based on natural polymers and thiourea salts showed potential applications. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | CARBOXYCELLULOSE NANOFIBERS ; BIOLOGICAL-ACTIVITIES ; ANTITUMOR-ACTIVITY ; THIOSEMICARBAZONES ; 6-AMINO-6-DEOXYCHITOSAN |
| 研究领域[WOS] | Polymer Science |
| WOS记录号 | WOS:000503279200083 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24819 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, XQ,Zhang, JJ,Chen, Y,et al. Synthesis, Characterization, and the Antioxidant Activity of Carboxymethyl Chitosan Derivatives Containing Thiourea Salts[J]. POLYMERS,2019,11(11):1810. |
| APA | Sun, XQ.,Zhang, JJ.,Chen, Y.,Mi, YQ.,Tan, WQ.,...&Guo, ZY.(2019).Synthesis, Characterization, and the Antioxidant Activity of Carboxymethyl Chitosan Derivatives Containing Thiourea Salts.POLYMERS,11(11),1810. |
| MLA | Sun, XQ,et al."Synthesis, Characterization, and the Antioxidant Activity of Carboxymethyl Chitosan Derivatives Containing Thiourea Salts".POLYMERS 11.11(2019):1810. |
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