YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum
Cong, Ming; Wu, Huifeng1,2; Yang, Haiping3; Zhao, Jianmin1,2; Lv, Jiasen4; Wu, HF
Source PublicationECOTOXICOLOGY
ISSN0963-9292
2017-04-01
Volume26Issue:3Pages:459-469
KeywordAmmonia Nitrogen Gill Damage Neurotoxicity Ruditapes Philippinarum
DOI10.1007/s10646-017-1777-4
Contribution Rank[Wu, Huifeng; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Wu, Huifeng; Zhao, Jianmin] YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China; [Yang, Haiping] Inst Oceanol & Marine Fisheries, Nantong 226007, Peoples R China; [Lv, Jiasen] Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
Department中科院海岸带环境过程与生态修复重点实验室
AbstractAmmonia nitrogen has been a potential menace to aquatic animals along the coastline of China. Presently, the toxicological effects of ammonia nitrogen were mainly concentrated on fishes, while little attention has been paid to molluscs. In this study, the clam Ruditapes philippinarum was used as the target animal to investigate the toxic effects of ammonia nitrogen. Our results showed that ammonia exposure could significantly reduce the integrity of lysosomes in a dose-dependent manner. Metabolite analysis revealed that exposure doses and duration time of ammonia nitrogen could affect the variation profiles of gill metabolites. In detail, branched chain amino acids, glutamate, choline and phosphocholine were significantly decreased after a one-day exposure. Inosine and phenylalanine were found significantly increased and ATP was decreased after a three-day exposure. The changes of metabolites implied that metabolisms of muscle element, neurotransmission and cell apoptosis of gill tissues would be affected by ammonia exposure. Such inferences were supported by the diminished muscle element, decreased concentrations of catecholamines and increased apoptosis rates, respectively. Therefore, we take advantage of metabolomics integrated with conventional biological assays to find out that ammonia exposure could cause lysosome instability, metabolic disturbance, aberrant gill structures and changes to neurotransmitters, and would result in mollusk gill dysfunction in feeding, respiration and immunity.
Funding OrganizationNatural Science Foundation of China(NSFC 41406132) ; Natural Science Foundation of Jiangsu Province(JSSFC BK2012660) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA11020702) ; Public Science and Technology Research Funds Projects of Ocean(201505022)
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordLYSOSOMAL MEMBRANE STABILITY ; APOPTOSIS ; TOXICITY ; STRESS ; NMR ; IDENTIFICATION ; SPECTROSCOPY ; METABOLOMICS ; BIOMARKERS ; CHALLENGE
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS IDWOS:000399817400016
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/22056
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorWu, HF
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
3.Inst Oceanol & Marine Fisheries, Nantong 226007, Peoples R China
4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
Recommended Citation
GB/T 7714
Cong, Ming,Wu, Huifeng,Yang, Haiping,et al. Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum[J]. ECOTOXICOLOGY,2017,26(3):459-469.
APA Cong, Ming,Wu, Huifeng,Yang, Haiping,Zhao, Jianmin,Lv, Jiasen,&Wu, HF.(2017).Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum.ECOTOXICOLOGY,26(3),459-469.
MLA Cong, Ming,et al."Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum".ECOTOXICOLOGY 26.3(2017):459-469.
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