Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum

doi:10.1007/s10646-017-1777-4

YIC-IR > 中国科学院海岸带环境过程与生态修复重点实验室 > 污染过程与控制实验室

	Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum
	Cong, Ming; Wu, Huifeng1,2 ; Yang, Haiping 3; Zhao, Jianmin1,2 ; Lv, Jiasen 4; Wu, HF
发表期刊	ECOTOXICOLOGY
ISSN	0963-9292
	2017-04-01
卷号	26 期号:3 页码:459-469
关键词	Ammonia Nitrogen Gill Damage Neurotoxicity Ruditapes Philippinarum
DOI	10.1007/s10646-017-1777-4
产权排序	[Wu, Huifeng; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Wu, Huifeng; Zhao, Jianmin] YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China; [Yang, Haiping] Inst Oceanol & Marine Fisheries, Nantong 226007, Peoples R China; [Lv, Jiasen] Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
作者部门	中科院海岸带环境过程与生态修复重点实验室
英文摘要	Ammonia nitrogen has been a potential menace to aquatic animals along the coastline of China. Presently, the toxicological effects of ammonia nitrogen were mainly concentrated on fishes, while little attention has been paid to molluscs. In this study, the clam Ruditapes philippinarum was used as the target animal to investigate the toxic effects of ammonia nitrogen. Our results showed that ammonia exposure could significantly reduce the integrity of lysosomes in a dose-dependent manner. Metabolite analysis revealed that exposure doses and duration time of ammonia nitrogen could affect the variation profiles of gill metabolites. In detail, branched chain amino acids, glutamate, choline and phosphocholine were significantly decreased after a one-day exposure. Inosine and phenylalanine were found significantly increased and ATP was decreased after a three-day exposure. The changes of metabolites implied that metabolisms of muscle element, neurotransmission and cell apoptosis of gill tissues would be affected by ammonia exposure. Such inferences were supported by the diminished muscle element, decreased concentrations of catecholamines and increased apoptosis rates, respectively. Therefore, we take advantage of metabolomics integrated with conventional biological assays to find out that ammonia exposure could cause lysosome instability, metabolic disturbance, aberrant gill structures and changes to neurotransmitters, and would result in mollusk gill dysfunction in feeding, respiration and immunity.
文章类型	Article
资助机构	Natural Science Foundation of China(NSFC 41406132) ; Natural Science Foundation of Jiangsu Province(JSSFC BK2012660) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA11020702) ; Public Science and Technology Research Funds Projects of Ocean(201505022)
收录类别	SCI
语种	英语
关键词[WOS]	LYSOSOMAL MEMBRANE STABILITY ; APOPTOSIS ; TOXICITY ; STRESS ; NMR ; IDENTIFICATION ; SPECTROSCOPY ; METABOLOMICS ; BIOMARKERS ; CHALLENGE
研究领域[WOS]	Environmental Sciences & Ecology ; Toxicology
WOS记录号	WOS:000399817400016
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/22056
专题	中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室中国科学院海岸带环境过程与生态修复重点实验室
通讯作者	Wu, HF
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 3.Inst Oceanol & Marine Fisheries, Nantong 226007, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Cong, Ming,Wu, Huifeng,Yang, Haiping,et al. Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum[J]. ECOTOXICOLOGY,2017,26(3):459-469.
APA	Cong, Ming,Wu, Huifeng,Yang, Haiping,Zhao, Jianmin,Lv, Jiasen,&Wu, HF.(2017).Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum.ECOTOXICOLOGY,26(3),459-469.
MLA	Cong, Ming,et al."Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum".ECOTOXICOLOGY 26.3(2017):459-469.

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