Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic | |
| 其他题名 | Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic |
Wu, Huifeng1 ; Xu, Lanlan1,2; Ji, Chenglong1; Yu, Deliang1,2; Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Key Lab Coastal Zone Environm Proc,Yantai Inst Co, Yantai 264003, Peoples R China. Email:hfwu@yic.ac.cn
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| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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| ISSN | 1050-4648 |
| 2016-11-01 | |
| 卷号 | 58页码:514-520 |
| 关键词 | Mytilus Galloprovincialis Cadmium Arsenic Biological Effects Proteomics Metabolomics |
| DOI | 10.1016/j.fsi.2016.09.064 |
| 产权排序 | [Wu, Huifeng; Xu, Lanlan; Ji, Chenglong; Yu, Deliang] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Key Lab Coastal Zone Environm Proc,Yantai Inst Co, Yantai 264003, Peoples R China; [Xu, Lanlan; Yu, Deliang] Univ Chinese Acad Sci, Beijing 700049, Peoples R China |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | Cadmium (Cd) and arsenic (As) are the main metal/metalloid contaminants in the coastal environments of the Bohai Sea, China. In this work, a combined proteomic and metabolomic approach was applied to investigate the biological effects of Cd and As(V) in the early life stage (D-shape larvae) of mussel Mytilus galloprovincialis. Results indicated that Cd was a potential immune toxicant to D-shape larval mussel because of the numerous proteomic responses related to immune system. Additionally, Cd induced oxidative stress, cellular injury and disturbance in nucleic acid metabolism in D-shape larval mussels. However, only two identified proteins were significantly altered in As (V)-treated group, suggesting that D-shape larval mussel was less sensitive to As (V) than to Cd at protein level. These two proteins in response to As (V) suggested that As (V) influenced anti-oxidative system and cell proliferation in D-shape larval mussels. Metabolic responses indicated that Cd and As (V) induced disturbances in osmotic regulation and energy metabolism in D-shape larval mussels via different metabolic pathways. In addition, Cd reduced lipid metabolism as well. This work demonstrated that a combination of proteomics and metabolomics could provide an insightful view in the biological effects of pollutants in mussel M. galloprovincialis at an early life stage. (C) 2016 Published by Elsevier Ltd. |
| 文章类型 | Article |
| 资助机构 | NSFC(41676114) ; Natural Science Foundation of Shandong Province(JQ201310) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | LASER-DESORPTION/IONIZATION-TIME ; GENDER-SPECIFIC RESPONSES ; NMR-BASED METABOLOMICS ; BATHYMODIOLUS-AZORICUS ; CELL-CYCLE ; PROTEINS ; GEL ; IDENTIFICATION ; SENSITIVITY ; EXPRESSION |
| 研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS记录号 | WOS:000387523100061 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/17488 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Key Lab Coastal Zone Environm Proc,Yantai Inst Co, Yantai 264003, Peoples R China. Email:hfwu@yic.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Key Lab Coastal Zone Environm Proc,Yantai Inst Co, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 700049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Huifeng,Xu, Lanlan,Ji, Chenglong,et al. Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic[J]. FISH & SHELLFISH IMMUNOLOGY,2016,58:514-520. |
| APA | Wu, Huifeng,Xu, Lanlan,Ji, Chenglong,Yu, Deliang,&Wu, HF .(2016).Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic.FISH & SHELLFISH IMMUNOLOGY,58,514-520. |
| MLA | Wu, Huifeng,et al."Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic".FISH & SHELLFISH IMMUNOLOGY 58(2016):514-520. |
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