H-1 NMR-based metabolomics study on the physiological variations during the rat pregnancy process
Shen, GP; Li, ZS; Zhang, Y; Wu, HF; Feng, JH; Feng, JH (reprint author), Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China. jianghua.feng@xmu.edu.cn
2016-03-05
发表期刊MOLECULAR AND CELLULAR ENDOCRINOLOGY
ISSN0303-7207
卷号423期号:C页码:40-50
产权排序[Shen, Guiping; Li, Zhishui; Zhang, Yan; Feng, Jianghua] Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China; [Shen, Guiping] Univ Washington, Dept Anesthesiol & Pain Med, Northwest Metabol Res Ctr, Seattle, WA 98109 USA; [Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,CAS, Yantai 264003, Peoples R China
摘要In this study, NMR-based metabolomics in combination with multivariate pattern recognition technologies were employed to evaluate the physiological variations in the Wistar rats' plasma that are induced by pregnancy on the gestational days (GDs) 11, 14, 17 and 20. Untargeted metabolomics analysis revealed some possible mechanism of physiological effects for healthy pregnancies and showed a metabolic trajectory during pregnancy process. The levels of 24 metabolites were found to change significantly throughout pregnancy in maternal plasma. These metabolite changes involved in varied kinds of metabolic pathways including synthesis of biological substances, microbial metabolism in diverse environments, protein digestion and absorption, carbohydrate metabolism, digestion and absorption, mineral absorption, and ATP (Adenosine Triphosphate)-binding cassette transporters (ABC transporters). The substantial cores of all the metabolic pathways are promoting fetal growth and development and regulating maternal physiological state. This work showed relevant metabolic pathways perturbation in the maternal plasma due to normal pregnancy and provided the physical basis of time-dependent metabolic trajectory against which disease-related maternal physiological responses may be better understood in future studies. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
关键词Gestation Period Nmr Metabolomics Pattern Recognition Physiological Variation
作者部门中科院海岸带环境过程与生态修复重点实验室
DOI10.1016/j.mce.2016.01.003
项目资助者National Natural Science Foundation of China(31372546 ; Natural Science Foundation of Fujian Province of China(2014J01247 ; Fundamental Research Funds for the Central Universities(20720150018) ; State Scholarship Fund of China(201406315034) ; 81272581) ; 2015Y0032)
收录类别SCI
关键词[WOS]GESTATIONAL-AGE ; HEALTHY PREGNANCY ; REFERENCE VALUES ; BLOOD-PLASMA ; METABOLISM ; GROWTH ; URINE ; PREECLAMPSIA ; METABONOMICS ; TRYPTOPHAN
文章类型Article
语种英语
WOS研究方向Cell Biology ; Endocrinology & Metabolism
WOS记录号WOS:000371654200005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/10839
专题中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
通讯作者Feng, JH (reprint author), Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China. jianghua.feng@xmu.edu.cn
作者单位1.Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance
2.Univ Washington, Dept Anesthesiol & Pain Med, Northwest Metabol Res Ctr
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,CAS
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Shen, GP,Li, ZS,Zhang, Y,et al. H-1 NMR-based metabolomics study on the physiological variations during the rat pregnancy process[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016,423(C):40-50.
APA Shen, GP,Li, ZS,Zhang, Y,Wu, HF,Feng, JH,&Feng, JH .(2016).H-1 NMR-based metabolomics study on the physiological variations during the rat pregnancy process.MOLECULAR AND CELLULAR ENDOCRINOLOGY,423(C),40-50.
MLA Shen, GP,et al."H-1 NMR-based metabolomics study on the physiological variations during the rat pregnancy process".MOLECULAR AND CELLULAR ENDOCRINOLOGY 423.C(2016):40-50.
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