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题名:
H-1 NMR-based metabolomics study on the physiological variations during the rat pregnancy process
作者: Shen, GP; Li, ZS; Zhang, Y; Wu, HF; Feng, JH
刊名: MOLECULAR AND CELLULAR ENDOCRINOLOGY
ISSN号: 0303-7207
出版日期: 2016-03-05
卷号: 423, 期号:C, 页码:40-50
关键词: Gestation period ; NMR ; Metabolomics ; Pattern recognition ; Physiological variation
DOI: 10.1016/j.mce.2016.01.003
产权排序: [Shen, Guiping; Li, Zhishui; Zhang, Yan; Feng, Jianghua] Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China; [Shen, Guiping] Univ Washington, Dept Anesthesiol & Pain Med, Northwest Metabol Res Ctr, Seattle, WA 98109 USA; [Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,CAS, Yantai 264003, Peoples R China
通讯作者: Feng, JH (reprint author), Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China. jianghua.feng@xmu.edu.cn
作者部门: 中科院海岸带环境过程与生态修复重点实验室
英文摘要: In this study, NMR-based metabolomics in combination with multivariate pattern recognition technologies were employed to evaluate the physiological variations in the Wistar rats' plasma that are induced by pregnancy on the gestational days (GDs) 11, 14, 17 and 20. Untargeted metabolomics analysis revealed some possible mechanism of physiological effects for healthy pregnancies and showed a metabolic trajectory during pregnancy process. The levels of 24 metabolites were found to change significantly throughout pregnancy in maternal plasma. These metabolite changes involved in varied kinds of metabolic pathways including synthesis of biological substances, microbial metabolism in diverse environments, protein digestion and absorption, carbohydrate metabolism, digestion and absorption, mineral absorption, and ATP (Adenosine Triphosphate)-binding cassette transporters (ABC transporters). The substantial cores of all the metabolic pathways are promoting fetal growth and development and regulating maternal physiological state. This work showed relevant metabolic pathways perturbation in the maternal plasma due to normal pregnancy and provided the physical basis of time-dependent metabolic trajectory against which disease-related maternal physiological responses may be better understood in future studies. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
研究领域[WOS]: Cell Biology ; Endocrinology & Metabolism
项目资助者: National Natural Science Foundation of China(31372546 ; Natural Science Foundation of Fujian Province of China(2014J01247 ; Fundamental Research Funds for the Central Universities(20720150018) ; State Scholarship Fund of China(201406315034) ; 81272581) ; 2015Y0032)
关键词[WOS]: GESTATIONAL-AGE ; HEALTHY PREGNANCY ; REFERENCE VALUES ; BLOOD-PLASMA ; METABOLISM ; GROWTH ; URINE ; PREECLAMPSIA ; METABONOMICS ; TRYPTOPHAN
文章类型: Article
收录类别: SCI
语种: 英语
WOS记录号: WOS:000371654200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/10839
Appears in Collections:污染过程与控制实验室_期刊论文

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作者单位: 1.Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance
2.Univ Washington, Dept Anesthesiol & Pain Med, Northwest Metabol Res Ctr
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,CAS

Recommended Citation:
Shen, GP,Li, ZS,Zhang, Y,et al. H-1 NMR-based metabolomics study on the physiological variations during the rat pregnancy process[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016,423(C):40-50.
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