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Critical target identification and human health risk ranking of metal ions based on mechanism-driven modeling 期刊论文
CHEMOSPHERE, 2022, 卷号: 301, 页码: 9
作者:  Wang, Xiaoqing;  Teng, Yuefa;  Ji, Chenglong;  Wu, Huifeng;  Li, Fei
收藏  |  浏览/下载：308/0  |  提交时间：2022/07/26
Metal ions  p53  QSAR  Genetic toxicity  Human health risk  
典型持久性有机污染物与抑癌基因相互作用的分子模拟与验证 期刊论文
科学通报, 2015, 卷号: 60, 期号: 19, 页码: 1804-1809
作者:  吴惠丰;  曹璐璐;  李斐;  李雪花;  赵建民
Adobe PDF(1577Kb)  |  收藏  |  浏览/下载：739/322  |  提交时间：2016/12/15
持久性有机污染物  P53  2  分子模拟  2'  光谱法  4  4'-四溴联苯醚(Bde-47)  
Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study 期刊论文
TOXICOLOGY LETTERS, 2015, 卷号: 232, 期号: 2, 页码: 533-541
作者:  Li, Fei;  Cao, Lulu;  Li, Xuehua;  Li, Na;  Wang, Zijian;  Wu, Huifeng;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(2093Kb)  |  收藏  |  浏览/下载：863/303  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs)  P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Partial Least Squares (Pls)  
BDE-47对人胚肾细胞HEK293的毒理效应及作用机制 期刊论文
生态毒理学报, 2015, 卷号: ., 期号: 2, 页码: 236-242
作者:  曹璐璐;  李斐;  吴惠丰;  赵建民
浏览  |  Adobe PDF(304Kb)  |  收藏  |  浏览/下载：478/189  |  提交时间：2021/06/16
2,2’,4,4’-四溴联苯醚（BDE-47）  人胚肾细胞  细胞凋亡  氧化损伤  p53  Bax  
The interaction between organic phosphate ester and p53: An integrated experimental and in silico approach 期刊论文
MARINE POLLUTION BULLETIN, 2014, 卷号: 85, 期号: 2, 页码: 516-521
作者:  Li, Fei;  Li, Renmin;  Yang, Xianhai;  You, Liping;  Zhao, Jianmin;  Wu, Huifeng;  Li, F (reprint author), Chinese Acad Sci, YICCAS, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China. fli@yic.ac.cn;  hfwu@yic.ac.cn
浏览  |  Adobe PDF(915Kb)  |  收藏  |  浏览/下载：668/247  |  提交时间：2015/07/31
Organophosphate Flame Retardants (Opfrs) P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Multiple Linear Regression (Mlr)  
Construction and characterization of a cDNA library from human brain glioma cell line U251 with overexpressed exogenous p53 gene 期刊论文
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2010, 卷号: 9, 期号: 33, 页码: 5262-5268
作者:  Shu, Kun-xian;  Li, Yan-zhe;  Shao, Hong-bo;  Zhang, Ming-hua;  Wu, Li-xiang
收藏  |  浏览/下载：265/0  |  提交时间：2016/04/22
P53 Gene  P53 Downstream Gene  Cdna Library  Normalization