功能荧光染料、环境污染物及内源性生物分子动态监测工具的开发及应用、环境毒理与健康

张良伟，博士，副研究员。2013年6月，兰州大学获博士学位。2013年7月-2018年6月，兰州大学化学化工学院工作。2018年6月，加入中国科学院烟台海岸带研究所。主要研究方向是功能荧光染料开发、基于荧光成像技术发展环境污染物及内源性生物分子的动态监测工具、探究环境因素与疾病关系。目前，主持国家自然科学基金2项（青年项目，面上项目），参与4项。在J. Am. Chem. Soc., Chem. Sci., Chem. Commun., Anal. Chem.等期刊发表论文30余篇。

代表性论文：

10. Yang Yang, Liangwei Zhang*, Xia Zhang, Shudi Liu, Yue Wang, Li Zhang, Huiyan You,* Zuo Ma and Lingxin Chen*. A cysteine-selective fluorescent probe for monitoring stress response cysteine fluctuations, Chemical Communications, 2021, 57, 85810-5813.

9. Yue Wang, Li Zhang, Xiaoyue Han, Liangwei Zhang*, Xiaoyan Wang, Lingxin Chen*, Fluorescent probe for mercury ion imaging analysis: strategies and applications, Chemical Engineering Journal, 2021, 406， Number. 127166.

8. Shudi Liu, Di Feng, Liangwei Zhang*, He Song, Yue Wang , Xia Zhang , Qingjun Zhao, Lingxin Chen*, A reaction-based ratiometric fluorescent probe for mercury ion detection in aqueous solution, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 243, Number. 118817.

7. Liangwei Zhang*, Jie Kang, Shudi Liu*, Xia Zhang, Jinyu Sun, Yuesong Hu, Yang Yang, and Lingxin Chen*. A chemical covalent tactic for bio-thiol sensing and protein labeling agent design, Chemical Communications, 2020, 56, 11485-11488.

6. Xia Zhang, Yan Huang, Xiaoyue Han, Yue Wang, Liangwei Zhang*, and Lingxin Chen*, Evaluating the protective effects of mitochondrial glutathione on cerebral ischemia/reperfusion injury via near-infrared fluorescence imaging, Analytical Chemistry，2019, 91, 22, 14728-14736.

5. Liangwei Zhang*, Shoujiao Peng, Jinyu Sun, Ruijuan Liu, Shudi Liu, Jianguo Fang*, A ratiometric fluorescent probe of methionine sulfoxide reductase with improved response rate and emission wavelength, Chemical Communications, 2019, 55, 10, 1502-1505.

4. Yuesong Hu, Jie kang, Panpan Zhou, Xiao Han, Jinyu Sun, Shudi Liu, Liangwei Zhang*, Jianguo Fang*, A selective colorimetric and red-emitting fluorometric probe for sequential detection of Cu²⁺ and H₂S. Sensors and Actuators, B: Chemical, 2018, 255, 3155-3162.

3. Liangwei Zhang, Ruijuan Liu, Jie Kang, Jinyu Sun, Yanan Hou, Hong Yu and Jianguo Fang^*, A novel fluorescent probe for methionine sulfoxide reductases. SCIENTIA SINICA Chimica. 2017, 47, 1007-1014.

2. Liangwei Zhang, Shoujiao Peng, Jinyu Sun, Juan Yao, Jie Kang, Yuesong Hu and Jianguo Fang^*, A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease. Chemical Science, 2017, 8, 2966-2972.

1. Liangwei Zhang, Dongzhu Duan, Yaping Liu, Chunpo Ge, Xuemei Cui, Jinyu Sun, and Jianguo Fang*, Highly Selective Off−On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells. Journal of the American Chemical Society, 2014, 136, 226–233.