Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity
Li, Q; Tan, WQ; Zhang, CL; Gu, GD; Guo, ZY; Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. zhanyongguo@hotmail.com
Source PublicationCARBOHYDRATE RESEARCH
ISSN0008-6215
2015-12-11
Volume418Pages:44-49
KeywordChitosan Derivatives Antifungal Activity 1 Aliphatic Alcohol 2 Chain Length 3-triazole
DOI10.1016/j.carres.2015.10.005
Contribution Rank[Li, Qing; Tan, Wenqiang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Tan, Wenqiang] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Zhang, Caili] Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, Malvern, PA 19355 USA
Department海岸带生物学与生物资源利用所重点实验室
AbstractChemical modification of chitosan is increasingly studied for its potential of providing new application for chitosan. Here, we modify chitosan at its primary hydroxyl via 'click chemistry', and a group of novel water soluble chitosan derivatives with substituted 1,2,3-triazolyl group were designed and synthesized. Aliphatic alcohols with different lengths were used as functional dendrons to improve the antifungal activity of chitosan derivatives. Meanwhile, their antifungal activity against two kinds of phytopathogens was estimated by hypha measurement in vitro. All the chitosan derivatives exhibited excellent activity against tested fungi. It is found that the antifungal activity of chitosan derivatives against the tested fungi increases with augment in the chain length of straight aliphatic alcohols. And the hydrophobic moiety (alkyl) at the periphery of the synthesized chitosan derivatives tends to affect their antifungal activity. (C) 2015 Elsevier Ltd. All rights reserved.
SubtypeArticle
Funding OrganizationNational Natural Science Foundation of China(41206152 ; Science and Technology Service Network Initiative(KFJ-EW-STS-060) ; Science and Technology Project of Weihai(2012GNS004) ; Taishan Scholar Program of Shandong Province ; 41576156)
Indexed BySCI
Language英语
WOS KeywordFREE CLICK CHEMISTRY ; QUATERNIZED CHITOSAN ; ANTIBACTERIAL ACTIVITY ; ANTITUMOR-ACTIVITY ; MAILLARD REACTION ; MOLECULAR-WEIGHT ; IN-VITRO ; INHIBITORS ; 1,2,4-TRIAZOLES ; ANTIOXIDANT
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS IDWOS:000366219900006
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/9316
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorGuo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. zhanyongguo@hotmail.com
Recommended Citation
GB/T 7714
Li, Q,Tan, WQ,Zhang, CL,et al. Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity[J]. CARBOHYDRATE RESEARCH,2015,418:44-49.
APA Li, Q,Tan, WQ,Zhang, CL,Gu, GD,Guo, ZY,&Guo, ZY .(2015).Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity.CARBOHYDRATE RESEARCH,418,44-49.
MLA Li, Q,et al."Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity".CARBOHYDRATE RESEARCH 418(2015):44-49.
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