Surface-enhanced Raman scattering on a zigzag microfluidic chip: towards high-sensitivity detection of As(III)ions

doi:10.1039/c3ay42283f

	Surface-enhanced Raman scattering on a zigzag microfluidic chip: towards high-sensitivity detection of As(III)ions
	Qi, Nan 1,2; Li, Bowei2 ; You, Huiyan 1; Zhang, Wei 2,3; Fu, Longwen2 ; Wang, Yunqing2 ; Chen, Lingxin2 ; You, HY (reprint author), Dalian Univ, Environm & Chem Engn Coll, Dalian 116600, Peoples R China. dlyhy@dicp.ac.cn ; lxchen@yic.ac.cn
发表期刊	ANALYTICAL METHODS
ISSN	1759-9660
	2014
卷号	6 期号:12 页码:4077-4082
关键词	Silver Nanoparticles Spectroscopy Injection Ions Electrophoresis Microchannel Colloids Systems Scale
DOI	10.1039/c3ay42283f
产权排序	[Qi, Nan; You, Huiyan] Dalian Univ, Environm & Chem Engn Coll, Dalian 116600, Peoples R China; [Qi, Nan; Li, Bowei; Zhang, Wei; Fu, Longwen; Wang, Yunqing; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Zhang, Wei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
作者部门	中科院海岸带环境过程与生态修复重点实验室
英文摘要	In this study, a microfluidic platform was combined with surface-enhanced Raman scattering (SERS) to implement the rapid quantitative detection of As(III) ions in a continuous flow. Silver nanoparticles (AgNPs) were used as the SERS enhancement substrate, and glutathione (GSH) with 4-mercaptopyridine (4-MPY) was conjugated on the surface of the AgNPs. When As(III) ions encountered GSH/4-MPY functionalized AgNPs, the original monodispersed probes would aggregate because As(III) ions had a strong affinity to the GSH. As a result, Raman signals of 4-MPY adsorbed on the surface of the AgNPs were improved and the As(III) ions could be detected. Due to the advantages of microfluidics technology combined with SERS detection, the highly sensitive and reproducible analysis of As(III) ions was realized in several minutes. The proposed method allowed the quantitative analysis of As(III) ions with a linear range (3 to 200 ppb), and the limit of detection (LOD) of the As(III) ions was determined to be 0.67 ppb. The real water sample was also analyzed to confirm the practicability of the method and the consumption of several microliters of the sample was found to be environmentally friendly. This method also showed great potential in applying SERS combined with a lab-on-a-chip technique in the area of environmental monitoring with a high sensitivity and in an environmentally friendly way.; In this study, a microfluidic platform was combined with surface-enhanced Raman scattering (SERS) to implement the rapid quantitative detection of As(III) ions in a continuous flow. Silver nanoparticles (AgNPs) were used as the SERS enhancement substrate, and glutathione (GSH) with 4-mercaptopyridine (4-MPY) was conjugated on the surface of the AgNPs. When As(III) ions encountered GSH/4-MPY functionalized AgNPs, the original monodispersed probes would aggregate because As(III) ions had a strong affinity to the GSH. As a result, Raman signals of 4-MPY adsorbed on the surface of the AgNPs were improved and the As(III) ions could be detected. Due to the advantages of microfluidics technology combined with SERS detection, the highly sensitive and reproducible analysis of As(III) ions was realized in several minutes. The proposed method allowed the quantitative analysis of As(III) ions with a linear range (3 to 200 ppb), and the limit of detection (LOD) of the As(III) ions was determined to be 0.67 ppb. The real water sample was also analyzed to confirm the practicability of the method and the consumption of several microliters of the sample was found to be environmentally friendly. This method also showed great potential in applying SERS combined with a lab-on-a-chip technique in the area of environmental monitoring with a high sensitivity and in an environmentally friendly way.
文章类型	Article
资助机构	Chemistry ; Food Science & Technology ; Spectroscopy
收录类别	SCI
语种	英语
关键词[WOS]	SILVER NANOPARTICLES ; SPECTROSCOPY ; INJECTION ; IONS ; ELECTROPHORESIS ; MICROCHANNEL ; COLLOIDS ; SYSTEMS ; SCALE
研究领域[WOS]	Chemistry ; Food Science & Technology ; Spectroscopy
WOS记录号	WOS:000337121800023
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/8784
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	You, HY (reprint author), Dalian Univ, Environm & Chem Engn Coll, Dalian 116600, Peoples R China. dlyhy@dicp.ac.cn; lxchen@yic.ac.cn
作者单位	1.Dalian Univ, Environm & Chem Engn Coll, Dalian 116600, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qi, Nan,Li, Bowei,You, Huiyan,et al. Surface-enhanced Raman scattering on a zigzag microfluidic chip: towards high-sensitivity detection of As(III)ions[J]. ANALYTICAL METHODS,2014,6(12):4077-4082.
APA	Qi, Nan.,Li, Bowei.,You, Huiyan.,Zhang, Wei.,Fu, Longwen.,...&lxchen@yic.ac.cn.(2014).Surface-enhanced Raman scattering on a zigzag microfluidic chip: towards high-sensitivity detection of As(III)ions.ANALYTICAL METHODS,6(12),4077-4082.
MLA	Qi, Nan,et al."Surface-enhanced Raman scattering on a zigzag microfluidic chip: towards high-sensitivity detection of As(III)ions".ANALYTICAL METHODS 6.12(2014):4077-4082.